Original Article

Analysis of the Disease Spectrum Characteristics of Inherited Metabolic Liver Diseases in Two Hepatology Specialist Hospitals in Beijing over the Past 20 Years Wei Hou, Yuanzhi Huang, Tang Shang, Zheng Wang, Wei Zhang, Kefi Wang, Yinjie Gao, Min Zhang, Sujun Zheng Published online: March 21, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00030

Investigation of HO-1 Regulation of Liver Fibrosis Related to Nonalcoholic Fatty Liver Disease Through the SIRT1/TGF-ß/Smad3 Pathway Mengjiao Sun, Xiaoqing Wu, Zhandong Lin, Congyue Zhang, Jiawei Cui, Yaoyao Mao, Yue Shi, Jiaming Zhang, Yuemin Nan Published online: March 12, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00481

Intestinal Depletion of TM6SF2 Exacerbates High-fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease through the Gut-liver Axis Li-Zhen Chen, Yu-Rong Wang, Zhen-Zhen Zhao, Shou-Lin Zhao, Cong-Cong Min, Yong-Ning Xin Published online: March 12, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00407

Improved Discrimination and Predictive Ability of Novel Prognostic Scores for Long-term Mortality in Hospitalized Patients with Cirrhosis Sipu Wang, Gaoyue Guo, Han Wang, Xuqian Zhang, Wanting Yang, Jie Yang, Liping Wu, Chao Sun Published online: March 11, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00004

Mitochondrial Membrane Potential of CD8+ T Cells Predicts Bacterial Infection and Rapid Development of Acute-on-chronic Liver Failure in Cirrhotic Patients Xixuan Wang, Shuling Chen, Jing Fan, Yuxiang Gong, Hongli Liu, Lili Wang, Xiaoning Feng, Hui Zhou, Wenquan Zeng, Changhua Yi, Caiyun Zhang, Qingfang Xiong, Hao Ren, Yongfeng Yang Published online: February 25, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00452

Hydronidone for the Treatment of Liver Fibrosis Associated with Chronic Hepatitis B: Protocol for a Phase 3 Randomized Trial Xiaobo Cai, Yin Qu, Wen Xie, Yanbin Wang, Mengyu Zhao, Ling Zhang, Ying Luo, Ping Yin, Jun Cheng, Lungen Lu Published online: March 10, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00472

Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury Zhu Yang, Yang Tai, Tian Lan, Chong Zhao, Jin-Hang Gao, Cheng-Wei Tang, Huan Tong Published online: March 3, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00440

GTF3C2 Promotes the Proliferation of Hepatocellular Carcinoma Cells through the USP21/MEK2/ERK1/2 Pathway Yani Wu, Yingnan Yang, Youju Zhang, Qiuran Xu, Dongsheng Huang, Kangsheng Tu Published online: February 11, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00386

Review Article

Non-variceal Extrahepatic Portosystemic Shunts: A Review of Pathogenesis, Diagnosis, and Treatment Nicole M. Anastasio, George Y. Wu Published online: March 14, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00315

Beyond the Cure: Navigating Hepatocellular Risk and Surveillance after Hepatitis C Eradication in the Direct-acting Antiviral Era Chencheng Xie, Ashwani K. Singal Published online: February 8, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00499

Hot Topic Commentary

Ketamine Hepatotoxicity: An Underappreciated Cause of Liver Damage - Analysis by RUCAM Bianca Thakkar, George Y. Wu Published online: April 11, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2024.00478

Key Points and Future Directions from the 2024 Chinese Guidelines for Fatty Liver Disease Maria Tampaki, Evangelos Cholongitas Published online: March 27, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00051

Research Letter

Characteristics of a Chinese Cohort of Patients with Chronic Hepatitis C Infection (2019–2023) and a Case Report of Resistance-associated Substitutions to Sofosbuvir-velpatasvir Treatment Hao Xiong, Shaokun Pan, Chaohui Zhou, Hong Shi, Youhua Xie, Jinsheng Guo Published online: April 10, 2025 [ Html ] [ PDF ] [ Google Scholar ] [ Cite ] doi:10.14218/JCTH.2025.00033