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Pulmonary Manifestations among Patients with Primary Biliary Cirrhosis

  • Deniz Koksal*,1,
  • Aydin Seref Koksal2,3 and
  • Ahmet Gurakar3
Journal of Clinical and Translational Hepatology   2016;4(3):258-262

doi: 10.14218/JCTH.2016.00024

Received:

Revised:

Accepted:

Published online:

 Author information

Citation: Koksal D, Koksal AS, Gurakar A. Pulmonary Manifestations among Patients with Primary Biliary Cirrhosis. J Clin Transl Hepatol. 2016;4(3):258-262. doi: 10.14218/JCTH.2016.00024.

Abstract

Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic liver disease caused by diffuse inflammation, destruction and fibrosis of the intrahepatic bile ducts, ultimately leading to cirrhosis, portal hypertension and liver failure. The pathogenesis of PBC is incompletely understood, but current data suggest roles for genetic susceptibility and environmental factors. PBC is often thought of as an organ-specific autoimmune disease, which mainly targets the liver; however, lung tissue is also a site for autoimmune involvement of PBC. The pulmonary manifestations of PBC include abnormalities in gas transfer and pulmonary function, subclinical alveolitis, interstitial lung disease, granulomatous lung disease, airway disease, pulmonary hypertension, pulmonary hemorrhage and pleural effusion.

Keywords

Primary biliary cirrhosis, Pulmonary involvement, Pulmonary functions

Introduction

Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic liver disease caused by diffuse inflammation, destruction and fibrosis of intrahepatic bile ducts, ultimately leading to cirrhosis, portal hypertension and liver failure. The typical patient is a middle-aged woman, presenting with fatigue and itching or asymptomatic with an unexplained hepatomegaly or elevated serum alkaline phosphatase level.1,2 Anti-mitochondrial antibodies (AMAs) are detected in more than 95% of the patients and are considered as a diagnostic hallmark of PBC.

The pathogenesis of PBC is incompletely understood. Current data suggest that it is an autoimmune disease and involves genetic susceptibility and environmental factors.3,4 It is more common in individuals with a family history of PBC and often associated with other autoimmune diseases. Autoimmune diseases can be seen in up to 84% of PBC patients, with 41% having more than one concomitant autoimmune disease.5,6 In a recent population-based cohort study, among 322 Chinese patients with PBC, 46.6% had one or more connective tissue diseases (CTDs). The most common CTD was Sjögren’s syndrome (SS) (36.2%), followed by systemic lupus erythematosus (3.7%), polymyositis (3.1%), progressive systemic sclerosis (2.8%) and rheumatoid arthritis (2.8%).7

PBC is often thought of as an organ-specific autoimmune disease, which mainly targets the liver. However, lung tissue is also a possible site for autoimmune involvement of PBC and there is accumulating evidence indicating that PBC may involve multiple systems, including the pulmonary system.8 Therefore, physicians should be aware of potential pulmonary manifestations. Although the diagnosis of liver disease usually precedes pulmonary manifestations, the reverse can also occur.9 Sometimes, concomitant autoimmune diseases, which may be a contributor or primary etiology of a clinically apparent pulmonary disease, makes it difficult to discriminate PBC-associated lung involvement and other autoimmune diseases.10

The aim of this manuscript is to review pulmonary manifestations of PBC (Table 1). The pulmonary manifestations of PBC include abnormalities in gas transfer and pulmonary function, subclinical alveolitis, interstitial lung disease, granulomatous lung disease, airway disease, pulmonary hypertension, pulmonary hemorrhage and pleural effusion. Despite the main target of pulmonary involvement being the pulmonary parenchyma, the airways, pulmonary vasculature and pleura are also affected rarely. In the current literature, there is not much data about the pulmonary manifestations that occur among patients with PBC. Most of the literature has included small case series, case reports and scarce postmortem studies. Apart from this, it is difficult to discriminate sole pulmonary involvement of PBC from associated clinical conditions such as CTD-associated interstitial lung disease or portal hypertension related pulmonary hypertension. For these reasons, the frequency of pulmonary involvement in PBC is not known exactly.

Table 1.

Pulmonary manifestations of primary biliary cirrhosis

1) Gas transfer abnormalities
2) Subclinical alveolitis
3) Interstitial lung disease
  • Pulmonary fibrosis

  • Lymphoid interstitial pneumonia

  • Nonspecific interstitial pneumonia

  • Bronchiolitis obliterans with organizing pneumonia

4) Granulomatous lung disease
5) Airway disease
6) Pulmonary hypertension
7) Pulmonary hemorrhage
8) Pleural effusion

Gas transfer and pulmonary function abnormalities

Gas transfer abnormalities can be investigated by measuring diffusing capacity for carbon monoxide. Subclinical lung impairment, mostly represented by a reduced diffusion of alveolar gasses, is a recognized complication of PBC.11,12 Rodriguez-Roisin et al.13 were the first to study lung function tests in patients with PBC. They compared 4 subgroups, all of which were non-smokers matched by age, sex, height and socioeconomic status. The groups included 7 sole PBC patients, 7 concurrent PBC and SS patients, 7 sole sicca complex patients, and 14 healthy controls. There was no significant difference in the mean pulmonary function test values, but the mean diffusion capacity for carbon monoxide was significantly reduced in those PBC patients with concurrent PBC and SS or with sole sicca complex. The authors concluded that the respiratory, clinical and functional abnormalities found in PBC were related to the presence of an associated SS.13 Later on, Uddenfeldt et al.14 investigated lung function abnormalities in a small number of patients with PBC (n=25) and in age- and sex-matched healthy controls (n=17). The PBC group was divided into two groups: symptomatic (n=18) and asymptomatic (n=7). The prevalence of lung function impairment was 56%. Almost all abnormal lung function data were found in the symptomatic (i.e. pruritis, xanthoma, xanthelasmata, jaundice, hyperpigmentation, hepatosplenomegaly) patients. In the symptomatic PBC patients, there was a mean reduction in diffusion capacity and an elevated residual volume suggestive of hyperinflation, compared to the control group of patients. The authors suggested that PBC might be associated with a distal airway obstruction. However, they did not control the groups for smoking history or consider the presence of hepatopulmonary syndrome, which can cause a reduced diffusion in symptomatic, advanced PBC patients.14 Krowka et al.11 investigated the relationship between hepatic and pulmonary functions in never-smoked patients with PBC. They studied 67 patients, of who 20 were transplant candidates, and determined a significant relationship between the histological stage, disease severity of PBC and the steady-state diffusion capacity. Progressive deterioration of diffusion capacity was found to be associated with increasing severity of PBC. There was no relationship found between pulmonary function and the presence of sicca complex, SS or the clinical manifestations of portal hypertension.11 In another study that included 61 patients with different stages of PBC, the diffusion capacity was reduced in 24 (39%) of the patients. There was no significant relationship between diffusion capacity, advancement of liver disease and concomitant SS. However, reduced diffusion capacity showed a significant correlation with the presence of complete or incomplete scleroderma (also known as CREST syndrome, standing for calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) and with the presence of circulating anti-centromere antibodies.12

Subclinical alveolitis

PBC is characterized by continued assault of T lymphocyte-mediated attack on the small intralobular bile ducts, eventually leading to their gradual destruction.1,2 It is suggested that lymphocytic infiltration of PBC may not be limited to the liver but may also involve the lungs.15 In a study aiming to determine whether subclinical inflammatory alveolitis is associated with PBC, the authors compared the number and types of cells in bronchoalveolar lavage (BAL) fluid from patients with PBC, patients with alcoholic cirrhosis, and healthy controls. They found a subclinical alveolar inflammation comprised of T lymphocytes, mainly of the CD4 type, and activated alveolar macrophages in a high proportion of patients with PBC.16 One of the limitations of that study was the concomitant presence of SS in 7 out of 12 patients with PBC. Since it has been reported that up to 44% of patients with SS have subclinical alveolitis, it was difficult to discriminate the exact etiology.17 Spiteri et al.18 also studied BAL-derived cellular inflammatory patterns among patients with sarcoidosis, patients with PBC but without clinical lung involvement, and healthy controls. All patients with pulmonary sarcoidosis had lymphocytic alveolitis, with a proportion of 29.2%. Six out of 10 patients with PBC showed evidence of alveolitis, with an elevated lymphocyte count of 27.6%. Upon comparison of the patients with PBC and sarcoidosis, an overlap was found in the CD4/CD8 lymphocyte ratio predominance (4.13 vs. 5.6). The authors realized that, despite normal findings from physical examination and chest x-ray, 5 of 6 patients with alveolitis on BAL had an evidence of interstitial lung disease on subsequent computed tomography of the thorax.18

Interstitial lung disease (ILD)

PBC has been reported as associated with various ILDs, such as pulmonary fibrosis, lymphoid interstitial pneumonia (LIP), non-specific interstitial pneumonia (NSIP) and bronchiolitis obliterans with organizing pneumonia (BOOP).10,19 Concomitant SS increases the risk of ILD in patients with PBC.20 In a study composed of 109 consecutive PBC cases, concomitant SS was seen in 46 patients (42.2%). While the frequency of ILD was 21.7% in PBC patients with SS, it was only 1.6% in those without SS.21

The findings of both radiographic interstitial pattern and restrictive ventilatory impairment with gas transfer defects in some of the patients with chronic active hepatitis and PBC has led some authors to suggest an association of pulmonary fibrosis with chronic liver disease.22–24 Although the prevalence of pulmonary fibrosis was poorly defined, one review estimated it to be less than 5%.25 One of the reasons for this uncertainty could be the presence of concomitant CTDs, which would cloud the assumption of sole PBC attributable pulmonary fibrosis.10 In a necropsy series of 120 patients with PBC, none of the cases demonstrated pulmonary fibrosis findings.26 Golding et al.24 reported that 9 (13%) out of 70 patients with PBC had both radiological and pulmonary functional changes suggestive of pulmonary fibrosis; however, only 2 of them had biopsy-proven pulmonary fibrosis. The histological variant of fibrosis in association with PBC was believed to be similar to usual interstitial pneumonitis.8,10,27 Shen et al.28 systematically addressed the development of ILD as a complication of PBC in a prospective study. The study included 178 consecutive PBC patients who were followed for 6 years. The incidence of ILD was 15.7% (n=28). Of the patients with ILD, 53.6% had pulmonary symptoms and 88.2% had diffusion and restrictive ventilation impairment on pulmonary function tests. Although 42.9% of the patients with ILD did not have any other CTD, presence of Raynoud phenomenon and association with other CTDs were the risk factors for PBC patients to develop ILD.

LIP is obviously associated with PBC and SS. Up to 25% of LIP cases occur in association with SS, and complete or incomplete SS can be noted in 84% of PBC patients.6,29 Shen et al.28 performed lung biopsies in 5 patients with ILD. Histopathologic investigations revealed interstitial infiltrations with mainly lymphocytes suggestive of LIP in 3 patients. The other 2 biopsies were compatible with interstitial fibrosis, vascular hyperplasia and thickened vascular walls.28

BOOP may be one of the non-hepatic complications of PBC, especially in patients associated with other CTDs.30 Davison and Epstein31 reported a case of relapsing organizing pneumonitis in a man with PBC, CREST syndrome and chronic pancreatitis. BOOP can also manifest in isolated PBC cases. Chest radiographs show multiple, bilateral, peripherally distributed interstitial opacities. BOOP must be considered in the differential diagnosis of unresolved pneumonia in patients with PBC and respiratory symptoms. Strobel et al.32 reported an interesting case of PBC, for which the patient’s open lung biopsy revealed BOOP, LIP and destructive bronchiolitis. This dual histopathology was also reflected in a bimodal clinical phase and gave a viewpoint about the therapy. The first phase was probably BOOP characterized by dramatic response to corticosteroid treatment (within a 1-week period) and the second phase was probably LIP characterized by a slow normalization (over a 1-year period). All recognizable signs of lung disease slowly and completely resolved after addition of azathioprine to the therapeutic regimen.

Data about the management of pulmonary involvement in the course of PBC is very limited. Review of the literature revealed that patients experience a widely variable response to therapeutic agents such as steroids, cyclosporine and azathioprine.10 This heterogenicity might be due to different histopathological patterns that could not be clinically distinguishable. The case presented by Strobel et al32 also supported this hypothesis.

Granulomatous lung disease (GLD)

Sarcoidosis is a granulomatous disorder of unknown etiology that characteristically involves any organ of the body, but mainly the lungs. Although sarcoidosis does not meet the criteria for an autoimmune disorder, it can coexist with a wide variety of autoimmune diseases.33 There is also an association reported between PBC and sarcoidosis.34–36 A number of patients have features of both diseases, raising the question of whether they are within the spectrum of one disease or are two distinct clinical disorders that may share an autoimmune pathogenesis with some overlapping symptoms.37 Kishor et al38 reviewed 17 patients with sarcoidosis and PBC and suggested that a common pathway contributes to granuloma formation in both disorders. The prevalence of GLD related to PBC is not known, but it seems to be rare based upon case reports and case series. A large necropsy series of 120 PBC patients reported only 2 patients (1.6%) with widespread intrapulmonary granulomas without fibrosis; one of these patients had interstitial pattern on chest radiography and impaired gas transfer.26 Wallace et al.8 described 4 patients with PBC and concomitant SS, in whom symptomatic pulmonary involvement developed; three of these patients died of respiratory failure. The types of pulmonary involvement were interstitial fibrosis with accompanying vasculitis, which was thought to be a variant of idiopathic pulmonary fibrosis, lymphocytic bronchiolitis and GLD. GLD seems to be a steroid-responsive condition. Apart from steroids, other immunosuppressive drugs can also be used.39

Airway disease

Airflow obstruction has occasionally been reported in patients with PBC.11,14 Mild airway obstruction was present in 4 patients with concomitant sicca syndrome in a series of 67 patients with PBC.8 Obstructive lung disease was also reported in a patient with PBC and SS, secondary to an autoimmune process documented by immunofluorescent staining of lung parenchyma.8 Lymphocytic bronchitis/bronchiolitis is a non-specific type of airway disease characterized by infiltration of the large and small airways by lymphocytes. It was also described in a patient with PBC, suggesting that lymphocytic bronchitis/bronchiolitis may be part of a generalized autoimmune process in PBC.40

Pulmonary hypertension

Pulmonary vascular abnormalities have been noted in the course of PBC. There is a well-recognized association between portal hypertension of cirrhosis and an increased incidence of pulmonary hypertension.41 In patients with liver disease, portal hypertension plays an important role in the pathogenesis of pulmonary hypertension, namely porto-pulmonary hypertension.42 In a prospective study including 178 consecutive PBC patients with a follow-up of 6 years, the incidence of pulmonary hypertension was 11.8% (n=21). Among these patients, 4 had moderate to severe pulmonary hypertension, and 1 patient died of right heart failure, indicating a poor prognosis. Pulmonary hypertension was closely associated with portal hypertension and immunological dysregulation. It was noteworthy that more than 30% of the patients with pulmonary hypertension did not show any evidence of portal hypertension, suggesting that other mechanisms may also be involved in the pathogenesis of pulmonary hypertension in PBC patients.43 However, there are a few case reports with PBC-associated pulmonary hypertension concomitant with normal portal venous pressure.44–46 This rarity might be due to dismissal of primary pulmonary hypertension since most of the patients had associated portal hypertension due to liver disease.

Pulmonary hemorrhage

Diffuse alveolar hemorrhage associated with PBC has been reported in 2 case reports.47,48 However, in both cases, there are some conflicting data for an associating pulmonary hemorrhage directly to PBC itself. Bissuel et al.47 reported a 41-year-old woman presenting with life threatening intrapulmonary hemorrhages. The presence of antineutrophil cytoplasmic antibodies, focal segmental glomerulonephritis, and cutaneous leukocytoclastic vasculitis were all suggestive for the presence of a systemic vasculitis rather than PBC-associated alveolar hemorrhage.47 Komatsu et al.48 reported a patient with both PBC and Goodpasture’s syndrome. Postmortem examination of both lungs revealed diffuse hemorrhage probably due to pulmonary vasculitis related to the Goodpasture’s syndrome.48

Pleural effusion

Hepatic hydrothorax is defined as a pleural effusion in patients with cirrhosis, without a primary cardiac or pulmonary disease. The estimated prevalence of hepatic hydrothorax is about 5-10% in patients with cirrhosis.49,50 There are only a few case reports of PBC-associated hepatic hydrothorax.51,52 Other than hepatic hydrothorax, pleural effusion was described in a patient with LIP. Lymphocytic infiltration was shown in the thoracoscopic biopsy of the visceral pleura of the patient.53

Conclusions

In conclusion, PBC is a chronic progressive cholestatic liver disease caused by diffuse inflammation, destruction and fibrosis of intrahepatic bile ducts, ultimately leading to cirrhosis, portal hypertension and liver failure. The pathogenesis of PBC is incompletely understood. Current data suggest that it is an autoimmune disease involving genetic susceptibility and environmental factors. It is more common in individuals with a family history of PBC and often associated with other autoimmune diseases. PBC is often thought of as an organ-specific autoimmune disease, which mainly targets the liver. However, lung tissue is also a site for autoimmune involvement of PBC. The main target of pulmonary involvement is the pulmonary parenchyma, but the airways, pulmonary vasculature and the pleura can also be affected rarely. Currently, the frequency of pulmonary involvement in PBC is not known exactly and there is no data for the presence of autoantibodies to diagnose PBC-related pulmonary involvement.

Abbreviations

PBC: 

primary biliary cirrhosis

AMA: 

anti-mitochondrial antibodies

CTD: 

connective tissue diseases

SS: 

sjögren’s syndrome

CREST: 

calcinosis, raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia

BAL: 

bronchoalveolar lavage

ILD: 

interstitial lung disease

LIP: 

lymphoid interstitial pneumonia

NSIP: 

non-specific interstitial pneumonia

BOOP: 

bronchiolitis obliterans with organizing pneumonia

GLD: 

granulomatous lung disease

Declarations

Conflict of interest

None

Authors’ contributions

Writing content and formatting the table in the manuscript (DK), drafting sections of the document (ASK), critical revision and administration during manuscript writing (AG).

References

  1. Selmi C, Bowlus CL, Gershwin ME, Coppel RL. Primary biliary cirrhosis. Lancet 2011;377:1600-1609 View Article PubMed/NCBI
  2. Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med 2005;353:1261-1273 View Article PubMed/NCBI
  3. Jones DE. Pathogenesis of primary biliary cirrhosis. J Hepatol 2003;39:639-648 View Article PubMed/NCBI
  4. Gershwin ME, Selmi C, Worman HJ, Gold EB, Watnik M, Utts J. Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients. Hepatology 2005;42:1194-1202 View Article PubMed/NCBI
  5. Strassburg CP, Manns MP. Autoimmune tests in primary biliary cirrhosis. Baillieres Best Pract Res Clin Gastroenterol 2000;14:585-599 View Article PubMed/NCBI
  6. Culp KS, Fleming CR, Duffy J, Baldus WP, Dickson ER. Autoimmune associations in primary biliary cirrhosis. Mayo Clin Proc 1982;57:365-370 View Article PubMed/NCBI
  7. Wang L, Zhang FC, Chen H, Zhang X, Xu D, Li YZ. Connective tissue diseases in primary biliary cirrhosis: a population-based cohort study. World J Gastroenterol 2013;19:5131-5137 View Article PubMed/NCBI
  8. Wallace JG, Tong MJ, Ueki BH, Quismorio FP. Pulmonary involvement in primary biliary cirrhosis. J Clin Gastroenterol 1987;9:431-435 View Article PubMed/NCBI
  9. Martusewicz-Boros MM, Boros PW, Wiatr E. Respiratory system involvement in chronic liver diseases. Pol Arch Med Wewn 2013;123:635-642 View Article PubMed/NCBI
  10. Allan PF, Powers CR, Morris MJ. Pulmonary manifestations of primary autoimmune hepatobiliary disease. Clin Pulm Med 2005;12:232-245 View Article PubMed/NCBI
  11. Krowka MJ, Grambsch PM, Edell ES, Cortese DA, Dickson ER. Primary biliary cirrhosis: relation between hepatic function and pulmonary function in patients who never smoked. Hepatology 1991;13:1095-1100 View Article PubMed/NCBI
  12. Costa C, Sambataro A, Baldi S, Modena V, Todros L, Libertucci D. Primary biliary cirrhosis: lung involvement. Liver 1995;15:196-201 View Article PubMed/NCBI
  13. Rodriguez-Roisin R, Pares A, Bruguera M, Coll J, Picado C, Agusti-Vidal A. Pulmonary involvement in primary biliary cirrhosis. Thorax 1981;36:208-212 View Article PubMed/NCBI
  14. Uddenfeldt P, Bjerle P, Danielsson A, Nyström L, Stjernberg N. Lung function abnormalities in patients with primary biliary cirrhosis. Acta Med Scand 1988;223:549-555 View Article PubMed/NCBI
  15. Musialik J, Petelenz M, Jastrzebski D, Ziora D, Kondera-Anasz Z, Mertas A. Lymphocyte subsets in peripheral blood and bronchoalveolar lavage in patients with primary biliary cirrhosis. Med Sci Monit 2001;7:311-315 View Article PubMed/NCBI
  16. Wallaert B, Bonniere P, Prin L, Cortot A, Tonnel AB, Voisin C. Primary biliary cirrhosis. Subclinical inflammatory alveolitis in patients with normal chest roentgenograms. Chest 1986;90:842-848 View Article PubMed/NCBI
  17. Wallaert B, Dugas M, Dansin E, Perez T, Marquette CH, Ramon P. Subclinical alveolitis in immunological systemic disorders. Transition between health and disease?. Eur Respir J 1990;3:1206-1216 View Article PubMed/NCBI
  18. Spiteri MA, Johnson M, Epstein O, Sherlock S, Clarke SW, Poulter LW. Immunological features of lung lavage cells from patients with primary biliary cirrhosis may reflect those seen in pulmonary sarcoidosis. Gut 1990;31:208-212 View Article PubMed/NCBI
  19. Spiteri MA, Clarke SW. The nature of latent pulmonary involvement in primary biliary cirrhosis. Sarcoidosis 1989;6:107-110 View Article PubMed/NCBI
  20. Chen CT, Tseng YC, Yang CW, Lin HH, Chen PJ, Huang TY. Increased risks of spontaneous bacterial peritonitis and interstitial lung disease in primary biliary cirrhosis patients with concomitant Sjögren’s syndrome. Medicine (Baltimore) 2016;95:e2537 View Article PubMed/NCBI
  21. Liu B, Zhang FC, Zhang ZL, Zhang W, Gao LX. Interstitial lung disease and Sjögren’s syndrome in primary biliary cirrhosis: a causal or casual association?. Clin Rheumatol 2008;27:1299-1306 View Article PubMed/NCBI
  22. Turner-Warwick M. Fibrosing alveolitis and chronic liver disease. Q J Med 1968;37:133-149 View Article PubMed/NCBI
  23. Mason AM, McIllmurray MB, Golding PL, Hughes DT. Fibrosing alveolitis associated with renal tubular acidosis. Br Med J 1970;4:596-599 View Article PubMed/NCBI
  24. Golding PL, Smith M, Williams R. Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis. Am J Med 1973;55:772-782 View Article PubMed/NCBI
  25. Talwalkar JA, Lindor KD. Primary biliary cirrhosis. Lancet 2003;362:53-61 View Article PubMed/NCBI
  26. Stanley NN, Woodgate DJ. Mottled chest radiograph and gas transfer defect in chronic liver disease. Thorax 1972;27:315-323 View Article PubMed/NCBI
  27. Osaka M, Aramaki T, Okumura H, Kawanami O. Primary biliary cirrhosis with fibrosing alveolitis. Gastroenterol Jpn 1988;23:457-460 View Article PubMed/NCBI
  28. Shen M, Zhang F, Zhang X. Primary biliary cirrhosis complicated with interstitial lung disease: a prospective study in 178 patients. J Clin Gastroenterol 2009;43:676-679 View Article PubMed/NCBI
  29. Swigris JJ, Berry GJ, Raffin TA, Kuschner WG. Lymphoid interstitial pneumonia: a narrative review. Chest 2002;122:2150-2164 View Article PubMed/NCBI
  30. Harada M, Hashimoto O, Kumemura H, Taniguchi E, Shiratsuchi M, Harada R. Bronchiolitis obliterans organizing pneumonia in a patient with primary biliary cirrhosis and rheumatoid arthritis treated with prednisolone. Hepatol Res 2002;23:301 View Article PubMed/NCBI
  31. Davison AG, Epstein O. Relapsing organising pneumonitis in a man with primary biliary cirrhosis, CREST syndrome, and chronic pancreatitis. Thorax 1983;38:316-317 View Article PubMed/NCBI
  32. Strobel ES, Bonnet RB, Werner P, Schaefer HE, Peter HH. Bronchiolitis obliterans organizing pneumonia and primary biliary cirrhosis-like lung involvement in a patient with primary biliary cirrhosis. Clin Rheumatol 1998;17:246-249 View Article PubMed/NCBI
  33. Sakamoto N, Ishimatsu Y, Kakugawa T, Hara A, Hara S, Amenomori M. Sarcoidosis in a patient with systemic sclerosis and primary biliary cirrhosis. Intern Med 2010;49:1609-1611 View Article PubMed/NCBI
  34. Stanley NN, Fox RA, Whimster WF, Sherlock S, James DG. Primary biliary cirrhosis or sarcoidosis - or both. N Engl J Med 1972;287:1282-1284 View Article PubMed/NCBI
  35. Maddrey WC. Sarcoidosis and primary biliary cirrhosis. Associated disorders?. N Engl J Med 1983;308:588-590 View Article PubMed/NCBI
  36. Fagan EA, Moore-Gillon JC, Turner-Warwick M. Multiorgan granulomas and mitochondrial antibodies. N Engl J Med 1983;308:572-575 View Article PubMed/NCBI
  37. Reilly JJ, Mark EJ. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case-14-1998. A 49-year-old woman with primary biliary cirrhosis, pulmonary opacities, and a pleural eddusion. N Engl J Med 1998;338:1293-1301 View Article PubMed/NCBI
  38. Kishor S, Turner Ml, Borg BB, Kleiner DE, Cowen EW. Cutaneous sarcoidosis and primary biliary cirrhosis. J Am Acad Dermatol 2008;58:326-335 View Article PubMed/NCBI
  39. Franco I, Dubini A, Piciucchi S, Casoni G, Poletti V. Interstitial lung disease preceding primary biliary cirrhosis in a male patient. Rev Port Pneumol 2015;21:214-217 View Article PubMed/NCBI
  40. Chatté G, Streichenberger N, Boillot O, Gille D, Loire R, Cordier JF. Lymphocytic bronchitis/bronchiolitis in a patient with primary biliary cirrhosis. Eur Respir J 1995;8:176-179 View Article PubMed/NCBI
  41. Humbert M, Nunes H, Sitbon O, Parent F, Hervé P, Simonneau G. Risk factors for pulmonary arterial hypertension. Clin Chest Med 2001;22:459-475 View Article PubMed/NCBI
  42. Yang YY, Lin HC, Lee WC, Hou MC, Lee FY, Chang FY. Portopulmonary hypertension: distinctive hemodynamic and clinical manifestations. J Gastroenterol 2001;36:181-186 View Article PubMed/NCBI
  43. Wallwork J, Williams R, Calne RY. Transplantation of liver, heart, and lungs for primary biliary cirrhosis and primary pulmonary hypertension. Lancet 1987;2:182-185 View Article PubMed/NCBI
  44. Yoshida EM, Erb SR, Ostrow DN, Ricci DR, Scudamore CH, Fradet G. Pulmonary hypertension associated with primary biliary cirrhosis in the absence of portal hypertension: a case report. Gut 1994;35:280-282 View Article PubMed/NCBI
  45. Shen M, Zhang F, Zhang X. Pulmonary hypertension in primary biliary cirrhosis: a prospective study in 178 patients. Scand J Gastroenterol 2009;44:219-223 View Article PubMed/NCBI
  46. Honma F, Shio K, Monoe K, Kanno Y, Takahashi A, Yokokawa J. Primary biliary cirrhosis complicated by polymyositis and pulmonary hypertension. Intern Med 2008;47:667-669 View Article PubMed/NCBI
  47. Bissuel F, Bizollon T, Dijoud F, Bouletreau P, Cordier JF, Chazot C. Pulmonary hemorrhage and glomerulonephritis in primary biliary cirrhosis. Hepatology 1992;16:1357-1361 View Article PubMed/NCBI
  48. Komatsu T, Utsunomiya K, Oyaizu T. Goodpasture’s syndrome associated with primary biliary cirrhosis. Intern Med 1998;37:611-613 View Article PubMed/NCBI
  49. Lazaridis KN, Frank JW, Krowka MJ, Kamath PS. Hepatic hydrothorax: pathogenesis, diagnosis, and management. Am J Med 1999;107:262-267 View Article PubMed/NCBI
  50. Strauss RM, Boyer TD. Hepatic hydrothorax. Semin Liver Dis 1997;17:227-232 View Article PubMed/NCBI
  51. Alhaji M, Sadikot RT. A 62-year-old female patient with left-sided pleural effusion. Expert Rev Respir Med 2013;7:455-458 View Article PubMed/NCBI
  52. Wojcikiewicz TG, Gupta S. Primary biliary cirrhosis presenting with ascites and a hepatic hydrothorax: a case report. J Med Case Rep 2009;3:7371 View Article PubMed/NCBI
  53. Weissman E, Becker NH. Interstitial lung disease in primary biliary cirrhosis. Am J Med Sci 1983;285:21-27 View Article PubMed/NCBI