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A Case Report of Massive Unilateral Pleural Effusion in a Patient with Systemic Lupus Erythematosus Responded to Rituximab

  • Fatima Magzoub Mohamed Khatieb1,2,
  • Sara Hamza Abushama1,
  • Mohammed Elmujtba Adam Essa Adam3,4,5,* ,
  • Shaima N. Elgenaid6,
  • Abdelkareem A. Ahmed3,7,8,9,
  • Malaz Faiz Abdelrahman Elkhadir10,
  • Ziryab Imad Taha3,11,
  • Ayman Sati Sati Mohamed3,4,
  • Sadia Kamal Albadawi Mohamed12 and
  • Elnour Mohammed Elagib1,13
Exploratory Research and Hypothesis in Medicine   2021;6(1):28-33

doi: 10.14218/ERHM.2020.00057

Received:

Revised:

Accepted:

Published online:

 Author information

Citation: Khatieb FMM, Abushama SH, Essa Adam MEA, Elgenaid SN, Ahmed AA, Elkhadir MFA, et al. A Case Report of Massive Unilateral Pleural Effusion in a Patient with Systemic Lupus Erythematosus Responded to Rituximab. Explor Res Hypothesis Med. 2021;6(1):28-33. doi: 10.14218/ERHM.2020.00057.

Abstract

Systemic lupus erythematosus (SLE) is a systemic disease which affects mainly young females and can cause life-threatening conditions. Pleural effusion can occur in SLE patients and usually tends to be mild and bilateral. This report aims to highlight the clinical presentation and medical management of massive unilateral pleural effusions in SLE patients. Here we report a 35-year-old female diagnosed with SLE for six years. She presented with shortness of breath, severe pleuritic chest pain, and fatigue. Her clinical examination showed signs of massive pleural effusion on the right side which was confirmed later by a chest x-ray and computer tomography of the chest. An echocardiography and abdominal ultrasound indicated no pericardial effusion and no ascites. A pleural fluid analysis showed exudative fluid. Sputum culture and polymerase chain reaction on blood sample for Mycobacterium tuberculosis were negative. She was also edematous and pale but not cyanotic or jaundiced. The treatment included blood transfusions, antibiotics, rituximab, azathioprine, and hydroxychloroquine. The pleural effusion responded well to rituximab, and she was discharged after two months in good condition.

Keywords

Massive, Unilateral, Pleural effusion, Systemic lupus erythematosus, Rituximab

Introduction

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown origin affecting predominantly females at a young age with no predilection for specific organs.1,2 The overall prevalence of SLE is 0.2–1.5/1,000.3 However, the epidemiology remains undetected in many developing countries.4 In Sudan, many cases have been misdiagnosed due to low recognition of the disease at its early stages.

SLE may manifest with various features, such as fatigue, fever, arthritis, skin rash, and joint pain. It can cause severe life-threatening conditions by damaging the organs and tissues.2 Pleural effusion occurs in 16–50% of SLE patients and usually tends to be bilateral and minimal.5 However, massive unilateral pleural effusion in SLE is rarely reported. This case report aims to draw attention to the presentation and medical management of massive unilateral pleural effusion in SLE.

Case report

The patient is a 35-year-old housewife who is married with no children. Initially, she presented on March 2011 with a sudden onset history of joint pain, fatigue, a facial rash, hair loss, and oral and genital ulcers. Two months later, she developed loss of memory, confusion, convulsions, epistaxis, and rectal bleeding. Investigations showed low platelets count and a positive antinuclear antibodies (ANA) profile, anti dsDNA, anti-histones, and anti-sm antibodies (Table 1). Therefore she was diagnosed with SLE based on the clinical as well as the laboratory evidence. Consequently, she received pulse corticosteroids (1,000 mg/once per day for 3 days), azathioprine (50 mg every 12 hours), hydroxychloroquine (HCQ) (200 mg twice daily), and oral corticosteroids (10 mg once daily).

Table 1

General test results of the patient

TimeInvestigationResult
2011antinuclear antibodies½,000
dsDNAPositive (++)
NucleosomesPositive (+++)
HistonesPositive (+++)
Sm antibodyPositive (+++)
anti–Sjögren’s-syndrome-related antigen A autoantibodiesPositive (++)
Serum anti-mitochondrial antibody type 2Positive (+)
2016Complete Blood CountNormal
C-reactive Protein5
Erythrocytes sedimentation rate30
Total protein5.3
Serum albumin3
aspartate aminotransferase11
alanine aminotransferase33
24h urinary protein2,968.2 mg/24h
Urea55 mg/dl
S. Creatinine1.6 mg/dl
2018White Blood Cells5.3
Hemoglobin9.1
Platelet210
Erythrocytes Sedimentation Rate70
C-reactive protein1.8
Complement 3 and Complement 4 levelsLow
Immunoglobulin levelsNormal
Bleeding profileNormal
Urea67 raising to 173
Creatinine1.74 raising to 5.6
Potassium4.3 raising to 7
Uric acid8.1
Serum albumin3.1
Globulin levels4.2
Urine pus cells10–12
Urine Red Blood Cells8–10
Urine protein+
Urine castNo
Blood cultureNegative
Before dischargeComplete Blood CountNormal
Erythrocytes Sedimentation Rate37
C-reactive Protein0.5
Urea1.3
Serum Creatinine42

Her condition improved except for the low platelets count, for which she received mycophenolate mofetil (MMF), 500 mg twice daily, for 6 months. During this period, the azathioprine was discontinued. After six months of using MMF she continued on the previous drug regimen (HCQ) and azathioprine). Her condition was well controlled with her medications. In 2016, azathioprine and HCQ were discontinued and methotrexate was started in Thailand as she reported a history of joint pain at that time. After that, she developed bullous skin rashes over her face (Fig. 1), trunk, and arms. It was painful, itchy, and scarring. Therefore, methotrexate was stopped, and MMF was restarted. She experienced a good response; however, a few months later, she developed lower limb edema and elevated blood pressure. Investigations revealed high 24-hour urinary proteins, blood urea, and creatinine levels. Subsequently, belimumab (1,200 mg inf/month) was prescribed. After receiving two dosages of belimumab, the patient developed generalized body swelling and a new urticarial and purpuric rash in addition to the previous skin rash (Fig. 2). As a result, she was admitted to the hospital, the belimumab was stopped and she received diuretics, anti-hypertensive, MMF, and HCQ. Her condition then improved well. Six months later, the patient presented with shortness of breath, pleuritic chest pain, and fatigue. On examination, she was edematous and pale but not cyanotic or jaundiced. Her vital signs were normal, and a chest examination revealed signs of massive unilateral pleural effusion on the right side. A skin examination showed areas of hypo and hyperpigmentation with scarring and alopecia. Investigations showed elevated erythrocytes sedimentation rate (ESR), blood urea, and creatinine levels in addition to low complement levels (Table 1). A chest X-ray detected a massive right-sided pleural effusion, and a chest computed tomography (CT) showed right hydropneumothorax with shifted mediastinum (Fig. 3). An echocardiograph study was normal, and an abdominal ultrasound was negative for ascites with normal-sized kidneys and normal echogenicity. A pleural fluid analysis showed an accumulation of exudative fluid. And, since tuberculosis is common in Sudan, sputum culture and polymerase chain reaction (PCR) on blood sample for Mycobacterium tuberculosis were requested and both were negative. Also, the pleural fluid culture and sensitivity were negative. A pleural biopsy showed active chronic pleurisy (Table 2). The blood culture was done and was negative. The immune modulator medications were stopped, and she received antibiotics and a blood transfusion. Repeated pleural fluid aspirations of 2–2.5 L each time were performed. She received three haemodialysis sessions, and a chest tube was inserted which drained more than 3 L. Therefore, a pulmonologist was consulted for pleurodesis. Later, her condition improved and a chest tube was removed. She became asymptomatic and was advised to start rituximab. Her renal function normalized, and she was discharged in good condition and symptom free (Fig. 1c). HCQ (200 mg twice daily), azathioprine (100 mg in the morning and 50 mg in the evening), and prednisolone were prescribed. On the 9th of January, she received the first rituximab dose. The patient is now showing a very good response with more than one year without flare ups.

Photos of the patient during the presentation and after discharge.
Fig. 1  Photos of the patient during the presentation and after discharge.

(a) Facial skin rash, (b) edema, and a (c) skin rash and edema subsided after treatment with rituximab.

The skin rash and generalized body edema of the patient.
Fig. 2  The skin rash and generalized body edema of the patient.

(a) Bullous skin rash with scarring; (b) skin rash on the trunk; (c) lower limb edema; and (d) facial edema.

Imaging examination of the patient.
Fig. 3  Imaging examination of the patient.

(a) Right side hydro pneumothorax with a mediastinal shift in the CT scan; (b) right side pleural effusion visible in the chest X ray; and (c) a chest tube on the right side with a decreased amount of fluid.

Table 2

pleural fluid analysis

InvestigationResultNormal Value
Protein4.2 g/dlLess than 3 g/dl
Glucose101 mg/dl80–180 mg/dl
WBCs200 (60% neutrophil–40% lymphocytes)Less than 1,000 per cubic millimeter
LDH99U/Lless than 200U/L
Culture and sensitivityNegative
Pleural biopsyActive chronic pleurisy

Discussion

About 4–5% of patients with SLE can present with pulmonary involvement as an initial manifestation, while 50% of the patients can present with pulmonary manifestation as late complications.6 SLE can cause pleural disease, acute lupus pneumonitis, diffuse alveolar haemorrhage, chronic interstitial disease, pulmonary hypertension, pulmonary embolism, and other conditions; however, pleuritis is the most common pulmonary manifestation.7 Around half of the patients with pleuritic involvement had pleural effusion, and 93% had evidence of pleuritis at autopsy.7 In SLE, pleural effusion can be primary, such as that caused by lupus pleuritis, or secondary to other causes, such as infection, heart failure, pulmonary embolism, or renal failure.7

SLE usually presents with pleuretic chest pain, dyspnea, fever, and cough.7 Our patient presented with shortness of breath and chest pain. Her examination showed features of right-sided massive pleural effusion confirmed by a chest x-ray and CT scan. Pleural effusion in SLE tends to be bilateral and usually small-to-moderate in size, but, occasionally, it can be a massive effusion, and pleural fluid analysis is essential for diagnosis.8 It is typically exudative effusion with a high leukocyte count with prominent neutrophils.

Exudative pleural effusion occurs either due to entering of protein and cells through a highly permeable mesothelial membrane or due to impaired removal of proteins and cells.9 A biochemical analysis usually shows high proteins (pleural fluid/serum ratio greater than 0.5), elevated lactate dehydrogenase (LDH) (pleural fluid/serum ratio greater than 0.6), and normal or low glucose levels.7 In addition, a high ANA titer of at least 1:160 in pleural fluid and elevated serum C-reactive protein (CRP) levels can be indicative of lupus pleuritis.10,11 This patient underwent thoracocentesis, and the biochemical analysis of pleural fluid revealed normal glucose, high protein levels, and a raised neutrophil count, which was consistent with exudative fluid. Her CT scan showed a massive right-sided pleural effusion with mediastinum shift. Regarding the hydropneumothorax, it more likely developed as a complication of a chest tube insertion.

Heart failure, pulmonary tuberculosis, and lupus nephritis can be possible causes of pleural effusion in SLE patients. In a study done by Palavutitotai N et al.12 among 119 SLE patients, 37% presented with pleuritis as a first presentation and was accompanied by pericarditis in 16%. The most common cause of pleural effusion was found to be lupus pleuritis (52%), and other causes were tuberculous pleuritis (9%), parapneumonic effusion (7%), and transudate (15%).12 Our patient had negative sputum and PCR tests for Mycobacterium tuberculosis and a normal Echocardiography (ECHO) and abdominal ultrasound. Blood and pleural fluid cultures and sensitivity were negative. Patients with an active flare of SLE usually have normal CRP and high ESR. A high level of CRP is more indicative of infection in SLE patients rather than an active disease.13 Therefore, investigations of this patient excluded tuberculosis, heart failure, and infection as underlying causes of the pleural effusion.

The patient had recurrent flare ups of the disease as indicated by her symptoms of joint pain, skin rash, hair loss, and ulcers. Moreover, investigations during the last visit showed high urea and creatinine levels and low complement levels consistent with lupus nephritis, but the patient refused a renal biopsy. Active SLE was documented in 81% of patients with pleural effusion.12 In a case reported by Castaneda et al.,14 an African American female with a history of SLE presented with massive pleural effusion and concomitant class III lupus nephritis confirmed with a biopsy. Her condition improved, and both lupus nephritis and effusion were resolved with a four-week use of prednisone and MMF.14 This presentation is unique as it is a unilateral effusion unlike the usual bilateral pleural effusion in SLE.

Typical therapy for SLE consists of non-steroidal anti-inflammatory drugs (NSAIDs), HCQ, glucocorticoids, and immunosuppressive medications, but the drugs should be prescribed according to clinical manifestations. NSAID is recommended for fever, serositis, and musculoskeletal symptoms, and HCQ is helpful for skin involvement as well. Patients with severe disease and organ involvement (especially renal and central nervous system involvement) will benefit from a high dose of steroids and immunosuppressive medications, such as methotrexate, cyclophosphamide, azathioprine, mycophenolate or rituximab, especially if there is no response to glucocorticoids. MMF was introduced to the patient but stopped after six months due to patient concern about her fertility and the ability to conceive in the near future, as many reports indicated that immunosuppressive drugs in young patients may have deleterious effects on pregnancy, fertility, and teratogenicity to an unborn child.15 Recently, belimumab, approved to be the treatment of adult SLE patients with active, autoantibody-positive SLE, who are failed to respond to standard therapy.10,16 Some clinical reports indicate that belimumb is usually well-tolerated, but may carry a risk of adverse events, such as infections, hypersensitivity, and infusion reactions,17 and, hence, the administration of belimumb was stopped in our patient after the second dose when she reported an allergic reaction. For massive pleural effusion, many cases responded well to hydroxychloroquine, methylprednisolone, azathioprine, and cyclophosphamide.8,10 But refractory cases to the previous treatment were documented, and, in such cases, intravenous immunoglobulin was considered, and some cases responded well to talc pleurodesis and surgical pleurectomy.5,18 In this case, the patient responded to rituximab with clinical and radiological improvement. Few similar cases were documented, as in a case reported by Ocampo V et al.,19 in which a 22-year-old male with SLE developed recurrent pericardial and massive unilateral pleural effusion and responded well to tocilizumab.19

In summary, SLE and connective tissue disorders are mainly responsible for pleural effusion development, especially among younger females. The usual presentation is bilateral effusion that responds well to glucocorticoids. However, here we presented a case of SLE with unusual massive unilateral pleural effusion and generalized edema which responded well to rituximab.

Abbreviations

ANA: 

antinuclear antibodies

CRP: 

C-reactive protein

CT: 

computed tomography

ESR: 

erythrocytes sedimentation rate

ECHO: 

Echocardiography

HCQ: 

hydroxychloroquine

LDH: 

lactate dehydrogenase

MMF: 

mycophenolate mofetil

NSAIDs: 

non-steroidal anti-inflammatory drugs

PCR: 

polymerase chain reaction

SLE: 

systemic lupus erythematosus

Declarations

Acknowledgement

The authors wish to acknowledge Medical and Cancer research Institute (MCRI) for their support to conduct this research.

Ethical statement

The authors have obtained the written consent from the patient to publish this case report.

Funding

This study was funded by Medical and Cancer Research Institute (MCRI), Sudan.

Conflict of interest

The authors declare that they have no competing interests.

Authors’ contributions

Manuscript writing and critical revision (MEAEA, SNE, AAA); diagnose and treat the case (FMMK, SHA, EME); data collections and technical editing (ZIT, ASSM, MFAE, SKAM).

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