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Preliminary Study on Clinical Features of Cryptogenic Liver Cancer Based on Clinical Data of 128 Patients with Primary Liver Cancer

  • YuanHong Zhao1,*,
  • MaoYan Chen1,
  • RuiXue Yang1,* and
  • Qiang Lv1
Gastroenterology & Hepatology Research   2019;1(1):11-17

doi: 10.53388/ghr2019-12-004

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Citation: Zhao Y, Chen M, Yang R, Lv Q. Preliminary Study on Clinical Features of Cryptogenic Liver Cancer Based on Clinical Data of 128 Patients with Primary Liver Cancer. Gastroenterol & Hepatol Res. 2019;1(1):11-17. doi: 10.53388/ghr2019-12-004.

Abstract

Background

To compare the clinical features of viral and cryptogenic liver cancer and to provide evidence of or reference the clinical identification of cryptogenic liver cancer and diagnosis and treatment using Chinese and Western medicine.

Methods

A retrospective analysis of the clinical data (general conditions, laboratory indicators, initial symptoms, and Traditional Chinese medicine (TCM) syndrome types) of 92 cases of viral liver cancer (VLC) and 36 cases of cryptogenic liver cancer (CLC) was performed by using SPSS version 20.0 statistical software.

Results

There were significant differences in triglyceride, γ-glutamyl transpeptidase, and alkaline phosphatase levels, liver fibrosis index (Fibrosis 4 Score, APRI), and initial symptoms (P < 0.05) between VLC and CLC. However, there was no statistical difference in TCM syndrome types. Among the 128 patients with primary liver cancer, there was a high proportion of women with cryptogenic liver cancer. Compared to the VLC group, the CLC group was older, had a lower incidence of cirrhosis, and had a higher proportion of surgical resection.

Conclusions

Although the number of research cases was limited, the occurrence of cryptogenic liver cancer was more likely to be associated with abnormal metabolic factors. Cryptogenic liver cancer should be considered in the differential diagnosis when liver fibrosis indicators are detected.

Keywords

Cryptogenic liver cancer, Viral liver cancer, Clinical features, Risk factors, TCM syndrome

Copyright © 2025 Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhao Y, Chen M, Yang R, Lv Q. Preliminary Study on Clinical Features of Cryptogenic Liver Cancer Based on Clinical Data of 128 Patients with Primary Liver Cancer. Gastroenterol & Hepatol Res. 2019;1(1):11-17. doi: 10.53388/ghr2019-12-004.
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Article History
Received Revised Accepted Published
December 12, 2019
DOI http://dx.doi.org/10.53388/ghr2019-12-004
  • © 2025 Xia & He Publishing Inc.