Traditional Chinese herbal medicine plus triple therapy in treating Helicobacter pylori induced chronic atrophic gastritis: a meta-analysis and cumulative meta-analysis

Kai Xiong¹,
Ting-hui Yue¹,
Tao Yang²,
Wen-ting Hu¹,
Jia Deng¹ and
Tian-bao Xiao^2,*

Gastroenterology & Hepatology Research 2022;4(1):6

doi: 10.53388/ghr2022-03-048

Published online: March 30, 2022

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Citation: Xiong K, Yue TH, Yang T, Hu WT, Deng J, Xiao TB. Traditional Chinese herbal medicine plus triple therapy in treating Helicobacter pylori induced chronic atrophic gastritis: a meta-analysis and cumulative meta-analysis. Gastroenterol & Hepatol Res. 2022;4(1):6. doi: 10.53388/ghr2022-03-048.

Abstract

Objective

To evaluate the benefits of traditional Chinese herbal medicine (TCHM) plus triple therapy (TT) in the management of Helicobacter pylori (H. pylori)-induced chronic atrophic gastritis (CAG).

Methods

A comprehensive access and electronic database search were carried out from inception to June 2020. Prospective randomized trials (TCHM plus TT vs. TT) were selected to assess the eradication rate of H. pylori (ER of H. pylori), clinical symptom relief rate (SRR), treatment-related adverse reactions (TRAR) and 95% confidence intervals (CI) in the meta-analysis and cumulative meta-analysis (CMA). Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.

Results

33 studies contained 3,226 participants were included. Compared with the TT group, TCHM plus TT group showed a significantly higher ER of H. pylori (OR=4.14, 95% CI: 3.21-5.35; P=0.000) and SRR (OR=4.50, 95% CI: 3.59-5.64). Meanwhile, the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly (RR=0.43, 95% CI: 0.29-0.64; P=0.000). The results of the CMA, sorted by publication year, duration of treatment, and sample size, confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H. pylori and SRR.

Conclusions

The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H. pylori-induced CAG.

Keywords

Traditional Chinese herbal medicine, Triple therapy, Helicobacter pylori, chronic atrophic gastritis, Meta-analysis, Cumulative meta-analysis

Copyright © 2025 Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xiong K, Yue TH, Yang T, Hu WT, Deng J, Xiao TB. Traditional Chinese herbal medicine plus triple therapy in treating Helicobacter pylori induced chronic atrophic gastritis: a meta-analysis and cumulative meta-analysis. Gastroenterol & Hepatol Res. 2022;4(1):6. doi: 10.53388/ghr2022-03-048.

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Received	Revised	Accepted	Published
			March 30, 2022

DOI http://dx.doi.org/10.53388/ghr2022-03-048

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