Ion channel mechanism of gastrointestinal motility and gastric hypersensitivity in functional dyspepsia: a review

Functional dyspepsia (FD) is a regularly diagnosed clinical gastrointestinal ailment with a high incidence rate that can considerably impact patients' health and quality of life and impose a substantial financial burden. Modern research on the pathophysiology of functional dyspepsia has not thoroughly explained the underlying reasons. The condition does not manifest any significant organ abnormalities, which raises the disease's difficulty coefficient. Major pathogenic exceptions in FD include gastrointestinal motor dysfunction, gastrointestinal hormone secretion problem, visceral hypersensitivity, and brain-gut axis. Several ion channels have reportedly been implicated in the pathophysiological process of FD. Therefore, it is crucial to comprehend the probable activities of various ion channels in FD. This study focuses on the current state of research on the possible role of several ion channels in the pathogenesis of FD.