Clinical study on the treatment of acute pancreatitis with external application of Yi-Dan Therapy based on the method of "stagnation requiring dispersion": study protocol for a randomized controlled trial

Pei-Xin Ge¹,
Bo-Yi Jia²,
Nai-Wei Zhan²,
Li-Bao An²,
Qiao-Yan Zhang²,
Yan-Mei Cai²,
Xiao-Na Zhang²,
Shao-Dong Hao² and
Hong-Jie Cheng^2,*

Gastroenterology & Hepatology Research 2024;6(2):6

doi: 10.53388/ghr2024006

Published online: June 30, 2024

Author information

Citation: Ge PX, Jia BY, Zhan NW, An LB, Zhang QY, Cai YM, et al. Clinical study on the treatment of acute pancreatitis with external application of Yi-Dan Therapy based on the method of "stagnation requiring dispersion": study protocol for a randomized controlled trial. Gastroenterol & Hepatol Res. 2024;6(2):6. doi: 10.53388/ghr2024006.

Abstract

Background

Acute pancreatitis is an unpredictable and potentially lethal disease, causing tremendous pain in patients. The initial treatment of acute pancreatitis in modern medicine is supportive, but it is generally ineffective in relieving abdominal pain and distension. Traditional Chinese medicine has been shown to be more effective in regulating the body's homeostasis and reducing the clinical symptoms of pancreatitis. Yi-Dan ointment, derived from Dahuang-Mudan Decoction, is an effective external ointment for treating acute pancreatitis. The aim of this trial is to investigate the clinical efficacy of Yi-Dan ointment, providing a valuable complement to existing treatment options for pancreatitis.

Methods

This is a randomized controlled clinical trial with two parallel groups. Patients in the control group were given basic treatment and nursing for 7 days; in the treatment group, Yi-Dan ointment was applied externally in addition to basic treatment and nursing. The main indicator is the overall efficacy, serum amylase, acute physiology and chronic health evaluation â¡ score, symptom score, inflammatory markers, and classification of computed tomography.

Conclusion

The trial results will provide high-quality evidence for Yi-Dan ointment, and provide a complement to existing treatment options for pancreatitis.

Keywords

acute pancreatitis, traditional Chinese medicine, external treatment, Yi-Dan ointment, randomized controlled trial

Copyright © 2025 Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ge PX, Jia BY, Zhan NW, An LB, Zhang QY, Cai YM, et al. Clinical study on the treatment of acute pancreatitis with external application of Yi-Dan Therapy based on the method of "stagnation requiring dispersion": study protocol for a randomized controlled trial. Gastroenterol & Hepatol Res. 2024;6(2):6. doi: 10.53388/ghr2024006.

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Article History

Received	Revised	Accepted	Published
			June 30, 2024

DOI http://dx.doi.org/10.53388/ghr2024006

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