Hot Topic Commentary

• Defining the Value of Extracorporeal Liver Support in Acute and Acute-on-chronic Liver Failure   

  Bart van Hoek

  
• COVID-19 and Liver Transplantation: Challenges and Opportunities   

  Georgios Tsoulfas

  
• Differentiating Neonatal Dubin Johnson Syndrome from Biliary Atresia: Start Simply   

  Jaimy Villavicencio Kim, John Birk

  

Original Article

• Investigating the Effect of Metabolic Phenotypes on Health Events in Alcoholic and Nonalcoholic Fatty Liver Disease

  Hong Fan, Pengyan Zhang, Zhenqiu Liu, Renjia Zhao, Chen Suo, Xingdong Chen, Tiejun Zhang

  
• Alcoholic vs. Nonalcoholic Steatohepatitis: Vascular Branching Heterogeneity on Magnetic Resonance Imaging as a Diagnostic Marker

  Daniel Garrido, Nicholas Noverati, Justin Robbins, Jaydev K. Dave, Haresh Naringrekar, Donald G. Mitchell, Dina Halegoua-De Marzio

  

• Fas/FasL and Complement Activation are Associated with Chronic Active Epstein-Barr Virus Hepatitis

  Jing Lin, Miao-Fang Su, Jiao-Long Zheng, Lei Gu, Hai-Cong Wu, Xia Wu, Hai-Yan Lin, Zhi-Xian Wu, Dong-Liang Li

  
• 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients

  Zhihong Liu, Qinglong Jin, Yuexin Zhang, Guozhong Gong, Guicheng Wu, Lvfeng Yao, Xiaofeng Wen, Zhiliang Gao, Yan Huang, Daokun Yang, Enqiang Chen, Qing Mao, Shide Lin, Jia Shang, Huanyu Gong, Lihua Zhong, Huafa Yin, Fengmei Wang, Peng Hu, Qiong Wu, Chao Pan, Wen Jia, Chuan Li, Chang’an Sun, Junqi Niu, Jinlin Hou, the TMF Study Group

  
• Booster Vaccination in Infancy Reduces the Incidence of Occult HBV Infection in Maternal HBsAg-positive Children

  Yi Li, Lili Li, Yarong Song, Minmin Liu, Xiangjun Zhai, Zhongping Duan, Feng Ding, Liguo Zhu, Jie Jiang, Huaibin Zou, Jie Wang, Jie Li

  

• New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis

  Xiaoting Tang, Hai Li, Guohong Deng, Xin Zheng, Xianbo Wang, Yan Huang, Yanhang Gao, Zhongji Meng, Zhiping Qian, Feng Liu, Xiaobo Lu, Yu Shi, Beiling Li, Wenyi Gu, Xiaomei Xiang, Yan Xiong, Yixin Hou, Jun Chen, Na Gao, Sen Luo, Liujuan Ji, Jing Li, Rongjiong Zheng, Haotang Ren, Jinjun Chen

  
• Breath Biopsy^® to Identify Exhaled Volatile Organic Compounds Biomarkers for Liver Cirrhosis Detection

  Giuseppe Ferrandino, Giovanna De Palo, Antonio Murgia, Owen Birch, Ahmed Tawfike, Rob Smith, Irene Debiram-Beecham, Olga Gandelman, Graham Kibble, Anne Marie Lydon, Alice Groves, Agnieszka Smolinska, Max Allsworth, Billy Boyle, Marc P. van der Schee, Michael Allison, Rebecca C. Fitzgerald, Matthew Hoare, Victoria K. Snowdon

  

• Value of Non-tumoral Liver Volume in the Prognosis of Large Hepatocellular Carcinoma Patients After R0 Resection

  Dongliang Zuo, Yuntong Li, Hongzhi Liu, Dongxu Liu, Qinliang Fang, Pengtao Li, Liang Tu, Yu Xiong, Yongyi Zeng, Pingguo Liu

  
• STX5 Inhibits Hepatocellular Carcinoma Adhesion and Promotes Metastasis by Regulating the PI3K/mTOR Pathway

  Bin Zhang, Ziyin Zhao, Youpeng Wang, Tingting Guo, Mingyang He, Ge Guan, Pai Peng, Jinzhen Cai, Bingyuan Zhang, Xutao Liu, Qiaoling Song

  
• Augmenter of Liver Regeneration Monoclonal Antibody Promotes Apoptosis of Hepatocellular Carcinoma Cells

  Li-Li Huang, Fei-Yang Luo, Wen-Qi Huang, Hui Guo, Qi Liu, Ling Zhang, Ai-Shun Jin, Hang Sun

  
• Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity

  Chiao-Ling Tsai, Po-Sheng Yang, Feng-Ming Hsu, Ann-Lii Cheng, Wan-Ni Yu, Jason Chia-Hsien Cheng

  
• Evaluation of Ultrasound-based Surveillance for Hepatocellular Carcinoma in Patients at Risk: Results From a German Multicenter Retrospective Cohort Study

  Johannes Gillessen, Philipp Reuken, Peter-Marton Hunyady, Matthias Christian Reichert, Lucian Lothschütz, Fabian Finkelmeier, Matthias Nowka, Gabriel Allo, Fabian Kütting, Martin Bürger, Dirk Nierhoff, Hans-Michael Steffen, Christoph Schramm

  

• MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells

  Yuzhu Cao, Yawen Xia, Yufei Wang, Hang Shi, Yuanyuan Wu, Yin Lu

  
• Post-hepatoportoenterostomy Acoustic Radiation Force Impulse Elastography to Predict Two-year Outcome of Biliary Atresia

  Dongying Zhao, Yahui Li, Wei Xie, Wenjie Wu, Yan Chen, Yongjun Zhang

  

Review Article

• Impact of Helicobacter pylori Infection on the Pathogenesis and Management of Nonalcoholic Fatty Liver Disease   

  Marianna G. Mavilia-Scranton, George Y. Wu, Murali Dharan

  
• Role of Hydrogen Sulfide and Hypoxia in Hepatic Angiogenesis of Portal Hypertension   

  Huaxiang Yang, Mingjie Tan, Zhuqing Gao, Shanshan Wang, Lingna Lyu, Huiguo Ding

  
• Role of Noncoding RNAs in the Tumor Immune Microenvironment of Hepatocellular Carcinoma   

  Yue Lv, Zhen Wang, Kefei Yuan

  
• Application and Progress of Cultured Models of Gallbladder Carcinoma   

  Jiali Xing, Peiwen Ding, Xueshuai Wan, Gang Xu, Yilei Mao, Xinting Sang, Shunda Du, Huayu Yang

  
• Prognostic Impact of Surgical Margin Width in Hepatectomy for Colorectal Liver Metastasis   

  Katsunori Sakamoto, Toru Beppu, Kohei Ogawa, Kei Tamura, Masahiko Honjo, Naotake Funamizu, Yasutsugu Takada

  
• Efficacy of Vaccine Protection Against COVID-19 Virus Infection in Patients with Chronic Liver Diseases   

  Carmen Ka Man Cheung, Kimmy Wan Tung Law, Alvin Wing Hin Law, Man Fai Law, Rita Ho, Sunny Hei Wong

  

Guideline

• Guidelines on the Diagnosis and Management of Primary Biliary Cholangitis (2021)   

  Hong You, Weijia Duan, Shuxiang Li, Tingting Lv, Sha Chen, Lungen Lu, Xiong Ma, Ying Han, Yuemin Nan, Xiaoyuan Xu, Zhongping Duan, Lai Wei, Jidong Jia, Hui Zhuang, Chinese Society of Hepatology, Chinese Medical Association

  

Illuminating and Instructive Clinical Case

• Dramatic Response to Cabozantinib in a Patient with Refractory Hepatocellular Carcinoma with c-MET Amplification   

  Yun Beom Sang, Gwangil Kim, Sohyun Hwang, Haeyoun Kang, Hong Jae Chon

  

Short Communication

• Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic   

  Yee Hui Yeo, Xinyuan He, Fan Lv, Yunyu Zhao, Yi Liu, Ju Dong Yang, Jian Zu, Fanpu Ji, Mindie H. Nguyen