v
Search
Advanced Search

Publications > Journals > Exploratory Research and Hypothesis in Medicine > Article Full Text

  • Review Article
  • OPEN ACCESS

Nutritional Support Following Traumatic Brain Injury: A Comprehensive Review

  • Divine Nwafor1,
  • Joel Goeckeritz2,
  • Zahra Hasanpour2,
  • Caroline Davidson2 and
  • Brandon Lucke-Wold2,* 
 Author information
Exploratory Research and Hypothesis in Medicine   2023;8(3):236-247

doi: 10.14218/ERHM.2022.00086

Abstract

Traumatic brain injury (TBI) can contribute to extensive dysbiosis of the gastrointestinal system, leading to worsened outcomes. The importance of nutrition in recovery is underappreciated but highly important. In this focused review, we discuss the timing of nutritional interventions with supporting data. We highlight routes of administration that are important given the extent of injury often seen in TBI. The increased energy demands can be met through these approaches. Furthermore, patients need increased vitamins, minerals, and supplements. These interventions are constantly being refined. The current standards are reviewed with an emphasis on evidence-based practices.

Keywords

Nutrition, Traumatic brain injury, Supplements, Vitamins, Minerals

Introduction

Traumatic brain injury (TBI) is a leading cause of death globally.1 The estimated economic cost of TBI in the United States was 76.5 billion dollars in 2010.2 Additionally, it is estimated that 5.3 million Americans who suffer from TBI are burdened with long-term disability and increased dependence.3,4 Pharmaceutical agents that target facets of TBI pathophysiology have demonstrated limited efficacy.5 A growing area of interest in understanding TBI pathophysiology is the role of nutritional support in mitigating TBI sequelae.

Nutritional support is essential given that the human brain consumes 20% of total resting energy despite accounting for only 2% of total body mass.6 Malnutrition in critically ill patients promotes endocrine dysfunction, multiorgan failure, impaired immunity, and increased mortality. Nutritional therapy aims to prevent malnutrition and its complications. Alterations in metabolism and gastrointestinal dysfunction contribute to the nutritional deficits seen in TBI and other neuroinflammatory conditions such as sepsis, stroke, and coronavirus disease 2019 (COVID-19). Moreover, these nutritional deficits are often coupled with poor functional outcomes.7–11 Thus, optimization of nutritional care in critically-ill patients is needed to improve short- and long-term recovery. Additionally, studies highlighting an increased prevalence of malnutrition among TBI patients further emphasize the importance of adequate nutritional support post-TBI.9,12–15 Likewise, timing and route of nutritional therapy are also essential to treat TBI.16

Generally, TBI injuries are classified as primary and secondary injuries. The primary injury of TBI involves mechanical damage to the central nervous system (CNS). It is typified by tissue deformation, axonal shearing, and blood-brain barrier (BBB) dysfunction. The secondary injury of TBI, which occurs in response to the initial primary injury, is typified by cerebral edema, increased inflammatory cytokines, excitotoxicity, ischemia, reactive oxygen species, and immunosuppression.17 Together, these injuries affect cellular metabolism by creating a hypermetabolic and hypercatabolic state that ultimately increases caloric expenditure among TBI patients (Fig. 1).16,18,19 The increase in caloric expenditure is associated with increased lean body mass consumption, negative nitrogen balance, electrolyte imbalance, increased susceptibility to infections, longer hospital stays, and increased morbidity and mortality.18,20,21 Thus, optimal nutritional support post-TBI may be critical in mitigating the hypermetabolic and hypercatabolic responses associated with TBI. This review provides an overview of nutritional support following TBI and highlights promising findings of preclinical and clinical nutraceutical interventions that warrant future investigations.

Schematic representation of traumatic brain injury (TBI).
Fig. 1  Schematic representation of traumatic brain injury (TBI).

TBI causes primary and secondary injury. The primary injury results from the initial mechanical insult and is characterized by tissue damage, axonal shearing, and blood-brain barrier (BBB) dysfunction. The secondary response is initiated minutes to hours after TBI and is characterized by increased inflammatory cytokines, brain edema, excitotoxicity, reactive oxygen species (ROS), and immunosuppression. These alterations promote a hypermetabolic and hypercatabolic state that increases morbidity and mortality post-TBI. Optimal nutritional support post-TBI is a potential strategy to meet the increased metabolic demand associated with TBI. Image credit: BioRender.

Timing of nutritional support post-TBI

Early initiation of nutritional support following TBI is crucial in offsetting the acute catabolic state seen in TBI.18 Early nutrition supports the preservation of muscle mass, decreases infection complications, promotes cerebral homeostasis, and improves functional outcomes.22–24 Ideally, nutritional support should be started within 24–48 h post-TBI to provide 50% of resting energy expenditure (REE) within the first two weeks post-injury. Previous studies have also shown that patients with TBI need about 100–150% of REE. The REE is ideally measured by indirect calorimetry. If the measurement of REE is not possible by indirect calorimetry, administration of 25 kcal/kg/day, or 70% of the measured or estimated REE during the initial 7 to 10 days, is advised.25 In a recent study, failure to initiate nutritional support within 5–7 days post-TBI was associated with increased mortality by 2 to 4 folds.26 Though early initiation of nutritional support is vital post-TBI, it is also essential to consider that overfeeding may result in metabolic issues such as refeeding syndrome with electrolyte derangements. Furthermore, it is crucial to note that TBI patients may experience some difficulty maintaining caloric intake due to pain, loss of appetite, and other co-injuries that include facial fracture, oral injuries, and cervical immobilization.27,28

Nutritional requirements following TBI

When considering nutritional requirements after TBI, it is crucial to determine the optimal glucose, protein, and lipid concentrations needed for neuronal survival.28 Hyperglycemia and hypoglycemia can occur in TBI patients.21,29,30 Hyperglycemia is more common post-TBI and is thought to be caused by increased insulin resistance and worsening stress metabolism.31,32 This rise in blood glucose is associated with worsened outcomes post-TBI.30 Studies have demonstrated that blood glucose control with insulin therapy improved post-TBI outcomes; however, intensive insulin therapy compared to conventional insulin therapy worsened post-TBI outcomes, especially in patients with severe TBI.33–36 The suggested optimal blood glucose level post-TBI is 6–9 mmol/L (108–162 mg/dL).37,38

Patients with severe TBI may lose 10–15% lean body mass in a week without adequate nutrition.39 Protein catabolism is a major contributor to this loss, and is increased significantly in the acute phase of TBI, appears to peak at 8–14 days, and is related to TBI severity.40 Nitrogen excretion post-TBI is estimated to range from 0.2 to 0.28 g/kg/day.41,42 Aggressive supplementation with protein to mitigate nitrogen loss and maintain muscle mass is ineffective in reversing TBI’s catabolic state.43,44 However, current guidelines recommend the early provision of 1.5 to 2.0 g/kg/day of protein in TBI patients.28 Adequate free water should be provided to patients on these high protein diets to prevent azotemia, especially in patients with renal insufficiency.28 Anabolic hormone insulin growth factor 1 (IGF-1) has demonstrated promising results in restoring a positive protein balance post-TBI in patients receiving growth hormone.45 However, the use of growth hormone and IGF-1 in the management of critically ill patients is controversial, given that some studies have demonstrated increased mortality in critically ill patients treated with growth hormone.46,47

Monitoring fluid and electrolyte requirements are essential for caring for TBI patients. Immediately after TBI, patients may experience episodes of hypotension, often requiring intravenous fluid resuscitation.48–50 Patients treated with osmotic diuretics such as mannitol should be monitored for fluid depletion and resuscitated if needed. The ideal fluid (colloids versus crystalloids) to be used post-TBI is not well established.28,51 Consideration of fluid type requires extensive knowledge of the advantages and disadvantages of using that fluid. A large randomized controlled trial (SAFE-TBI) demonstrated that 4% albumin significantly increased mortality in TBI patients compared to patients that received normal saline (0.9% sodium chloride).52 Despite the SAFE-TBI findings, there is still some support for the continued use of albumin in treating TBI patients; however, the addition of crystalloid solution is encouraged. Additionally, when using albumin, clinicians are cautioned to use high concentration solutions, infuse at low rates, avoid high blood pressures and vasopressors, avoid low hemoglobin concentrations, and encourage frequent physiotherapy to activate the lymphatic recirculation system.51

As with albumin, intravenous dextrose should be used with caution in the acute phase of TBI due to an increased risk of hyperglycemia.53 While fluid resuscitation is essential, TBI patients must not receive excessive fluids as this may worsen brain edema and increase the risk for hemodilution, acidosis, and acute respiratory distress syndrome (ARDS).51,54,55 Electrolyte repletion in patients with TBI is vital. Hypotonic solutions should be avoided in patients with hyponatremia. Hyponatremia is very common in TBI patients and is often caused by cerebral salt-wasting syndrome (CSWS) or the syndrome of inappropriate antidiuretic hormone (SIADH) release. If hyponatremia is not adequately treated, hyperchloremic acidosis may ensue. On the other hand, if treated too aggressively with osmotic diuretics, pronounced hypernatremia may ensue. Other electrolytes that require monitoring post-TBI include potassium, magnesium, calcium, and phosphate.51 Daily nutritional requirements post-TBI are shown in Table 1.

Table 1

Energy requirements following traumatic brain injury (TBI)

Glucose requirements
  Glucose2–3 g/kg/24 h
Protein requirements
  Protein1–1.5 g/kg/24 h
Lipid requirements
  Lipid0.5–2 g/kg/24 h
Electrolyte requirements
  Sodium1–1.4 mmol/kg/24 h
  Potassium0.7–0.9 mmol/kg/24 h
  Phosphate0.15–0.30 mmol/kg/24 h
  Magnesium0.04 mmol/kg/24 h
  Calcium0.11 mmol/kg/24 h

The table was adapted from Sundstrøm’s research.51

Routes of nutritional support post-TBI

The route of nutritional support is an important consideration following the stabilization of vitals and intracranial pressure in patients with TBI. Many TBI patients face difficulties with swallowing, and some may require mechanical ventilation; thus, the enteral nutritional route is the preferred method of nutritional support, especially within 24–48 h post-TBI.28 Enteral formulas with partially digested fats and proteins are preferred over non-digested formulas due to their ability to enhance gastric emptying and digestion.20 Furthermore, early enteral nutrition has been shown to significantly decrease mortality, the risk of metabolic derangements, pressure ulcer formation, and hepatobiliary dysfunction in TBI patients.24,56–58 Several feeding strategies need to be considered when initiating enteral nutrition. First, the patient’s head needs to be elevated by 30 to 45 degrees off the bed to decrease reflux.59 Second, graduated feeding may be attempted in patients initially intolerant to enteral nutrition. These patients can be started initially at 20 mL/h and advanced to their specific goal by 10–20 mL/h every 6–8 h. Furthermore, continuous enteral nutrition is well tolerated compared to bolus enteral nutrition.28,60

Enteral nutrition is achieved by passing a tube from the nasal cavity to the stomach or intestine. In the case whereby the patient is on a mechanical ventilator, the tube can be passed from the mouth.51 Prokinetic agents such as erythromycin and metoclopramide can be used as singular therapies or combined to enhance gut motility in the short term for patients with gut motility dysfunction.61,62 If the prokinetic drugs are unsuccessful in aiding bowel motility or are not well tolerated, small bowel feeding can be considered over gastric feeding. There is a growing recommendation for small bowel feeding in the acute phase of TBI over nasogastric feeding because small bowel feeding has been shown to reduce the incidence of infections, enhance feeding tolerance, and decrease reflux.25,63,64 Additionally, if the need for enteral nutrition exceeds 2–4 weeks, percutaneous enteral gastrostomy (PEG) may be preferable.51

Although enteral nutrition is the preferred route of nutritional support post-TBI, parenteral nutrition can also be considered if there is a delay in obtaining enteral access or failure to meet nutritional needs within 3–7 days of enteral nutrition and in heavily sedated patients.33 However, it is important to note that parenteral nutrition increases the risk of hyperglycemia, infection, hepatic steatosis, loss of gut barrier integrity, and immunosuppression.18 Daily requirements for parenteral nutrition are administered by a three-chamber bag comprising glucose, fats, and amino acids. When starting parenteral nutrition, several important factors must be considered. For instance, it is prudent to use a dedicated nutritional central venous catheter that is separate from those used to deliver medications or fluids. Also, the nutritional line must be inspected frequently.51,65 A recent retrospective study showed that TBI patients managed with a combination of enteral and parenteral nutrition demonstrated improved clinical outcomes.66 However, future randomized controlled trials (RCTs) are needed to corroborate this finding.

Vitamins, minerals, and nutritional supplementation post-TBI

Support for using vitamins, minerals, and supplements in treating TBI has increased in recent years.5,67,68 This section discusses a list of vitamins, minerals, and dietary supplements examined in preclinical and clinical TBI studies. These findings are also concisely summarized in Tables 2 and 3.

Table 2

Supplementation of vitamins and minerals in preclinical models of traumatic brain injury (TBI)

Vitamins and mineralsDosage usedProposed/suggested mechanismFindings
ATRA (vitamin A metabolite)10 mg/kgAnti-inflammatory and anti-apoptotic effectsBrain protective effects but no improvement in neurological and motor deficits in a mouse TBI model
Vitamin B2 (Riboflavin) & Magnesium7.5 mg/kg (Vitamin B2); 1 mmol/kg (Magnesium)Anti-oxidant effectsReduced behavioral impairments, lesion size, edema formation, and expression of GFAP in rat TBI model. Synergistic with Magnesium.
Magnesium sulfate & n-acetyl L tryptophan30 mg/kg (Magnesium); 2.5 mg/kg (n-acetyl L tryptophan)Anti-oxidant effectsReduced BBB permeability and improved functional outcomes in rat TBI model
Vitamin B3 (Nicotinamide)50 mg/kg, 500 mg/kg or continuous infusion of 12 mg/kg/h with LD of 75 mg/kgIncreased cellular energy as an NAD+ precursor.Neuroprotective effects and alleviation of behavioral deficits in a rat TBI model. Synergistic with Progesterone.
Vitamin B6 (Pyridoxine)300 mg/kg or 600 mg/kgIncreased oxygen delivery to damaged tissues.Alleviation of locomotor behavioral deficits in Rat TBI model. However, only the 600 mg/kg dose showed tissue sparing effect.
Vitamin B9 (Folic acid)80 µg/kg or 800 µg/kgDecreased homocysteine levels(1) Early functional recovery in female TBI piglets treated with 80 µg/kg; (2) No improvement in behavioral outcomes in rats post-TBI treated with 80 µg/kg (low dose) or 800 µg/kg (high dose). Moreover, 800 µg/kg dose worsened neuronal loss
Vitamin B12 (Cobalamin)0.5 mg/kg or 1.5 mg/kgDownregulation of the endoplasmic reticulum stress-related apoptosisImprovement in neurological functional recovery in a mouse TBI model
Vitamin C (Ascorbic Acid) & Vitamin E (α-tocopherol)45 mg/kg or 60 mg/kg (Vitamin C); 45 mg/kg or 60 mg/kg (Vitamin E)Improved SOD activity.Reduction of oxidative stress in rat TBI model.
Vitamin C (Ascorbic Acid) & Simvastatin20 mg/kg (Ascorbic acid) and 15 mg/kg (Simvastatin)Diminished vascular inflammatory responseCombination treatment with ascorbic acid and simvastatin improved neurological recovery in a rat TBI model
Vitamin D & Progesterone1 µg/kg (Vitamin D) and 16 mg/kg (Progesterone)Anti-inflammatory effects.Reduced markers of inflammation and neuronal cell death were observed in the rat TBI model. Synergistic with progesterone.
Vitamin E (α-tocopherol)500 IU/kgInvolvement of BDNF and Sir2.Improved cognition scores in a mouse TBI model.
Vitamin E (α-tocopherol)2 IU/g chow dietReduction in lipid peroxidationDecreased amyloidosis and improved memory impairment in Alzheimer’s disease mouse post-TBI
Zinc180 ppmAttenuation of redox signaling.Reduced neuropsychiatric symptoms in rat TBI model.
Selenium1.5 mg/kgAnti-oxidant effectReduction in lipid peroxidation in a rat TBI model
Melatonin5 mg/kgAttenuation of oxidative stressReduction in lipid peroxidation in a rat TBI model

ATRA, all-trans retinoic acid; BBB, blood-brain barrier; BNDF, brain-derived neurotrophic factor; GFAP, glial fibrillary acidic protein; NAD+; Sir2, silent information regulator 2; SOD, superoxide dismutase; TBI, traumatic brain injury.

Table 3

Dietary supplement uses in clinical and preclinical models of traumatic brain injury (TBI)

Dietary supplementsDosage usedProposed/suggested mechanismFindings
Creatine400 mg/kgIncreased phosphocreatine levels and ATP-buffering capability.Reduction of headache frequency, fatigue, and dizziness in a pilot study of 39 adolescents post-TBI. Up to 50% reduction of cortical damage in rat TBI model.
DHA10 mg/kg/d or 40 mg/kg/dIncrease in anti-oxidant capacity molecules, including SOD and Sir2.Decreased axonal injury and apoptotic markers in rat TBI model.
Curcumin500 ppmInvolvement of BDNF.Reduction in oxidative stress, conserved synaptic plasticity, and cognitive function in rat TBI model.
Resveratrol100 mg/kg(1) Action via heme oxygenase-1; (2) Suppression of the NLRP3 inflammasomeReduced neuroinflammation and secondary brain injury in mice mTBI model.
Enzogenol1,000 mg/dAnti-inflammatory and anti-oxidant effectsImproved cognitive function in a phase II RCT in patients treated for mild TBI.
Sulforaphane5 mg/kgInduction of Nrf2-driven genesReduced cerebral edema and BBB permeability in rat TBI model. Working memory also improved.
Ginseng20–80 mg/kg(1) Increased expression of NGF, GDNF, NCAM, and BrdU/nestin neural stem cells; (2) Decreased apoptotic cell death, downregulation of inflammatory cytokines, upregulation of anti-inflammatory interleukin-10, and increased SOD activityImproved recovery of neurological function and reduced neuronal cell loss in rat TBI model.
Astaxanthin25 mg/kg or 75 mg/kgIncreased BDNF, GAP-43, and SYP expressionNeuroprotection improved sensorimotor and enhanced cognitive function in a mouse TBI model
Melatonin5 mg/kgAttenuation of oxidative stressReduction in lipid peroxidation in a rat TBI model
N-Acetylcysteine(1) 150 mg/kg (rat study); (2) 4 g loading dose followed by 4 g for four days and 3 g for three days (human study)Attenuation of oxidative stress(1) Reduction in lipid peroxidation in a rat TBI model; (2) Resolution of early sequelae of blast-induced mTBI
Pycnogenol150 mg/kgAttenuation of oxidative stressAmeliorated oxidative stress, synaptic protein loss, and inflammatory cytokines in a rat TBI model

BBB, blood-brain barrier; BNDF, brain-derived neurotrophic factor; BrdU, Bromodeoxyuridine; DHA, docosahexaenoic Acid; GDNF, glial cell line-derived neurotrophic factor; NGF, nerve growth factor; NCAM, neuronal cell adhesion molecule; NSC, neural stem cell; NLRP3, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3; Nrf2, nuclear factor erythroid 2-related factor 2; RCT; randomized controlled trial; Sir2, silent information regulator 2; SOD, superoxide dismutase; TBI, traumatic brain injury.

Vitamins and Minerals

Vitamin A (retinol)

Although vitamin A supplementation has not been investigated in TBI, a recent study demonstrated a role for the bioactive vitamin A active metabolite, all-trans retinoic acid (ATRA). A study by Hummel et al. showed that male adult mice treated with ATRA (10 mg/kg) immediately after TBI and within the first three days post-TBI demonstrated a reduction in lesion size, astrogliosis, axonal injury, and the hippocampal granule cell layer was protected; however, ATRA did not significantly improve neurological and motor deficits.69

Vitamin B2 (riboflavin) and magnesium

When administered to rats post-TBI, riboflavin, a powerful anti-oxidant, significantly reduced behavioral impairments, lesion size, edema formation, and expression of the glial fibrillary acidic protein (GFAP).70 A later study by the same group demonstrated that co-administration of riboflavin (7.5 mg/kg) and magnesium (1 mmol/kg) led to a synergistic improvement in functional recovery compared to individual treatments.71 Additionally, treatment of magnesium sulfate (30 mg/kg) alone or in combination with n-acetyl L tryptophan (2.5 mg/kg) in rats post-TBI has been shown to alleviate blood-brain-barrier permeability and improve functional outcomes.72 Clinical studies supporting the use of magnesium after TBI have had mixed results.73–75

Vitamin B3 (nicotinamide)

Nicotinamide increases available cellular energy as a precursor to nicotinamide adenine dinucleotide (NAD+), thus alleviating post-injury cellular stress. When administered, nicotinamide (50 mg/kg or 500 mg/kg) provided neuroprotective effects and alleviated behavioral deficits in rodents following TBI.76–78 Nicotinamide (continuous infusion of 12 mg/kg/h with a loading dose of 75 mg/kg) also demonstrated potential synergistic effects with progesterone with regards to neuroprotection after TBI; however, further investigations are needed to identify the window of opportunity for intervention and treatment duration.79

Vitamin B6 (pyridoxine)

Pyridoxine is an essential cofactor involved in several metabolic enzymatic reactions. Additionally, pyridoxine plays a crucial role in the synthesis of brain neurotransmitters.80 Supplementation of pyridoxine (300 mg/kg or 600 mg/kg) in rats post-TBI demonstrated significant improvement in locomotor behavioral performance compared to vehicle controls. Moreover, the neuroprotective effects of pyridoxine supplementation post-TBI were shown to be dose-dependent. The authors suggested that the benefit of pyridoxine supplementation post-TBI may be related to improved oxygen delivery to damaged tissues, given that pyridoxine has been shown to upregulate erythrocyte affinity for oxygen.81,82

Vitamin B9 (folic Acid)

Folic acid is well recognized for its role in fetal neural tube closure during pregnancy.83,84 Folic acid deficiency has been shown to contribute to impaired cognition and dementia.85,86 Likewise, supplementation of folic acid after hemorrhagic stroke has been shown to be protective.87 While the role of folic acid in TBI is limited, an earlier study by Naim et al. showed that female piglets post-TBI treated with folic acid (80 µg/kg) demonstrated improved cognitive function in the acute period (day one post-TBI).88 In contrast, Vonder Haar et al. showed that neither low (80 µg/kg) nor high dose folic acid (800 µg/kg) improved behavioral outcomes in adult rats post-TBI. In fact, a high dose of folic acid (800 µg/kg) administered post-TBI in rats increased neuronal loss compared to vehicles.89

Vitamin B12 (cobalamin)

Like folic acid, cobalamin plays a critical role in neuronal function.90 Administration of cobalamin (0.5 mg/kg or 1.5 mg/kg) in male mice post-TBI showed significant improvement in neurological functional recovery. Further experiments demonstrated that the neurological recovery post-TBI in mice treated with cobalamin might be due to the downregulation of the endoplasmic reticulum stress-related apoptosis signaling pathway.91

Vitamin C (ascorbic acid)

Ascorbic acid plays a vital anti-oxidant role in scavenging harmful free radicals in brain cells.92,93 Furthermore, the levels of ascorbic acid are decreased after a neurological injury such as TBI.94 Supplementation of ascorbic acid (45 mg/kg or 60 mg/kg) and α-tocopherol (45 mg/kg or 60 mg/kg) demonstrated a reduction in oxidative stress and improved superoxide dismutase activity in rats post-TBI.95 Another study showed that administration of ascorbic acid (20 mg/kg) alone or in combination with simvastatin (15 mg/kg) in rats post-TBI significantly attenuated brain endothelial inflammation and improved neurological recovery (ascorbic acid and simvastatin alone) respectively.96

Vitamin D

Research data examining the independent use of vitamin D supplementation for treating TBI is lacking. However, vitamin D is a promising substance used as a neuroprotective adjuvant in post-TBI progesterone therapy. Combination treatment of vitamin D (1 µg/kg) and progesterone (16 mg/kg) showed reduced markers of inflammation and neuronal cell death in a rat TBI model.97 Interestingly, vitamin D deficiency deteriorates TBI outcomes and attenuates the protective benefits of progesterone after TBI in rats. These findings were reversed with vitamin D supplementation.98 Ongoing randomized placebo-controlled clinical trial examining the effects of high and low-dose vitamin D supplementation on inflammatory cytokines, clinical outcomes, and mortality in patients with severe TBI will further elucidate the role of vitamin D in TBI recovery.99

Vitamin E

Treatment with vitamin E attenuates cellular repair following tissue injury.100 Moreover, vitamin E protects cells from free radicals due to its anti-oxidant properties.101 Supplementation of vitamin E (500 IU/kg) for four weeks demonstrated improved cognition scores in a mice TBI model. These effects are credited to vitamin E’s role in increasing the brain levels of brain-derived neurotrophic factor (BNDF) and silent information regulator 2 (Sir2).102 Other studies have suggested that vitamin E supplementation post-TBI is neuroprotective via the reduction of lipid peroxidation.103,104

Zinc and selenium

Zinc supplementation post-TBI is controversial. While some studies have suggested that zinc levels increase following brain injury, others have suggested that zinc levels decrease.67,105–107 Despite this discrepancy, zinc supplementation studies have shown promising results in preclinical models of TBI. Zinc supplementation (180 ppm) in rats demonstrated behavioral resiliency to TBI-induced neuropsychiatric symptoms of depression and anxiety.108 The mechanism through zinc’s neuroprotective effects in TBI is still uncertain. However, one study suggested that zinc may affect redox signaling directly.109 Selenium is another mineral shown to have a neuroprotective effect in rats post-TBI.110 However, clinical trials examining the impact of early selenium administration post-TBI have shown mixed results.111,112

Dietary supplements

Creatine

Creatine supplementation increases phosphocreatine levels in the brain, thereby providing adenosine triphosphate (ATP)-buffering capability in TBI-induced hypoxia and cortical blood flow reduction.113–115 Six months of creatine supplementation, given at doses of 400 mg/kg of body weight, correlated with a decrease in TBI symptoms such as frequency of headaches, fatigue, and dizziness in a cohort of 39 adolescents.116 Additionally, Sullivan et al. showed that rats fed with 1% creatine-enriched diet four weeks prior to TBI initiation showed a 50% reduction in cortical damage.117

Docosahexaenoic acid (DHA)

Studies suggest that DHA may play a role in mitigating the cognitive dysfunction seen post-TBI.5 Wu et al. showed that DHA chow supplementation significantly increased DHA content in the brain of post-TBI rats and lessened cognitive decay associated with TBI. Possible mechanisms revolve around preserving membrane integrity via an increase in anti-oxidant capacity molecules superoxide dismutase (SOD) and Sir2.118 In another study, 30 days of prophylactic supplementation of DHA (10 mg/kg/d or 40 mg/kg/d) in rats post-TBI showed a reduction in injured axons and decreased apoptotic markers.119 In general, dosages of 1 to 7.5 g/d have been demonstrated as being safe for human consumption.120

Curcumin

Curcumin is the primary bioactive substance found in turmeric and has been associated with anti-inflammatory properties. In a TBI rat model, curcumin (500 ppm) given for four weeks prior to injury mitigated TBI-associated oxidative stress, conserved synaptic plasticity, and improved behavioral outcomes via normalization.121

Resveratrol

In a mild TBI mouse model, resveratrol supplementation (100 mg/kg) demonstrated reduced neuroinflammation and secondary brain injury.122,123 Resveratrol is thought to act via the neuroprotective and anti-oxidant properties of heme oxygenase-1 and has shown synergistic properties with melatonin.124 Additionally, resveratrol has been shown to have a neuroprotective effect post-TBI via suppression of the nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP3) inflammasome.123

Enzogenol

Enzogenol is a flavonoid-rich extract known for its anti-oxidant and anti-inflammatory properties.125 Class 2B evidence has demonstrated that enzogenol supplementation (1,000 mg/day) may improve cognitive function in patients with mild TBI.126

Sulforaphane

Commonly found in cruciferous vegetables, sulforaphane (5mg/kg) attenuated blood-brain-barrier permeability, reduced cerebral edema, and improved working memory in rats following TBI. Sulforaphane’s beneficial effects were linked to the induction of cytoprotective, nuclear factor erythroid 2-related factor 2(Nrf2)-driven genes and associated protein products.127

Ginseng

Ginseng is a traditional Chinese herb with a bioactive component, saponins, that have been linked with reducing inflammation.128 Rats who received ginseng saponins (20–80 mg/kg) following TBI demonstrated improved recovery of neurological function and reduced neuronal cell loss. These effects were associated with an increased expression of nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), and neuronal cell adhesion molecule (NCAM), inhibited expression of neurite outgrowth inhibitor- A, B (Nogo-A and Nogo-B), tenascin-C (TN-C), increased number of Bromodeoxyuridine (BrdU)/nestin-positive neural stem cells (NSC), decreased apoptotic cell death, downregulation of inflammatory cytokines, upregulation of anti-inflammatory interleukin-10, and increased SOD activity.129,130

Miscellaneous supplements

Astaxanthin is a carotenoid and an anti-oxidant. Astaxanthin (25 mg/kg or 75 mg/kg) has been shown to reduce lesion size, decrease neuronal loss, and improve sensorimotor and cognitive recovery in a mouse TBI model.131 Additionally, melatonin (5 mg/kg) and N-Acetylcysteine (150 mg/kg) administration post-TBI has also been shown to be neuroprotective via attenuation of oxidative stress.110,132 In a double-blind, placebo-controlled RCT blast TBI study, N-Acetylcysteine (4 g loading dose followed by 4 g for four days and 3 g for three days) was shown to significantly mitigate blast-induced mild TBI symptoms that include dizziness, confusion, hearing loss, headache, impaired memory, and sleep disturbances by day seven post-TBI compared to placebo.133 Pycnogenol (PYC), a powerful natural anti-oxidant, has anti-inflammatory and anti-oxidative stress effects that may be protective in many neuroinflammatory conditions.134–138 An ongoing double-blind, placebo-controlled RCT aims to address the neuroprotective effects of PYC on the clinical, nutritional, and inflammatory status of TBI patients.139 The findings from the PYC RCT are promising, given that in a rat model of TBI, PYC (150 mg/kg) alleviated oxidative stress, synaptic protein loss, and inflammatory cytokines.140

Future Directions

Future studies are needed to examine the long-term impact of adequate nutritional care in adult and pediatric patients with TBI. Most of the vitamin, mineral, and supplement studies discussed in this review were conducted on animal models. RCTs are needed to examine whether the demonstrated potential of the vitamins, minerals, and supplements extrapolate to human TBI. Additionally, given that gastrointestinal dysfunction is apparently post-TBI, there may be a plausible role for probiotics, prebiotics, and fecal transplantation as tools that mitigate the nutritional deficit seen in many TBI patients.

Conclusion

Nutrition improves outcomes for patients with neurotrauma. This focused review highlights the recommended calorie distribution to maintain energy requirements. This must be maintained even if different routes of administration are utilized. Furthermore, emerging evidence has indicated the importance of vitamins, minerals, and supplements. The field continues to change, but emerging innovation is piloting improvements for overall outcomes following brain injury.

Abbreviations

ARDS: 

acute respiratory distress syndrome (ARDS)

ATRA: 

all-trans retinoic acid

BBB: 

blood-brain barrier

BNDF: 

brain-derived neurotrophic factor

BrdU: 

Bromodeoxyuridine

COVID-19: 

coronavirus disease 2019

CSWS: 

cerebral salt-wasting syndrome

CNS: 

central nervous system

DHA: 

docosahexaenoic Acid

GDNF: 

glial cell line-derived neurotrophic factor

GFAP: 

glial fibrillary acidic protein

IGF-1: 

insulin growth factor 1

NAD+: 

nicotinamide adenine dinucleotide

NGF: 

nerve growth factor

NCAM: 

neuronal cell adhesion molecule

NSC: 

neural stem cell

NLRP3: 

nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3

Nogo-A and Nogo-B: 

neurite outgrowth inhibitor- A, B

Nrf2: 

nuclear factor erythroid 2-related factor 2

PEG: 

percutaneous enteral gastrostomy

PYC: 

Pycnogenol

RCT: 

randomized controlled trial

REE: 

resting energy expenditure

SIADH: 

syndrome of inappropriate antidiuretic hormone

Sir2: 

silent information regulator 2

SOD: 

superoxide dismutase

TN-C: 

tenascin-C

TBI: 

traumatic brain injury

Declarations

Acknowledgement

None.

Funding

This study received no specific grant from any funding agency in the public, commercial, or not-for-profit sector.

Conflict of interest

The authors have no conflicts of interest related to this publication.

Authors’ contributions

Study concept and design (BL-W), drafting of the manuscript (DCN, JG, ZH, CD, and BL-W), critical revision of the manuscript (DCN and BL-W), and study supervision (BL-W). All authors have contributed significantly to this study and approved the final manuscript.

References

  1. Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol 2008;7(8):728-741 View Article PubMed/NCBI
  2. Humphreys I, Wood RL, Phillips CJ, Macey S. The costs of traumatic brain injury: a literature review. Clinicoecon Outcomes Res 2013;5:281-287 View Article PubMed/NCBI
  3. Thurman DJ, Alverson C, Dunn KA, Guerrero J, Sniezek JE. Traumatic brain injury in the United States: A public health perspective. J Head Trauma Rehabil 1999;14(6):602-615 View Article PubMed/NCBI
  4. Nwafor DC, Brichacek AL, Foster CH, Lucke-Wold BP, Ali A, Colantonio MA, et al. Pediatric Traumatic Brain Injury: An Update on Preclinical Models, Clinical Biomarkers, and the Implications of Cerebrovascular Dysfunction. J Cent Nerv Syst Dis 2022;14:11795735221098125 View Article PubMed/NCBI
  5. Scrimgeour AG, Condlin ML. Nutritional treatment for traumatic brain injury. J Neurotrauma 2014;31(11):989-999 View Article PubMed/NCBI
  6. Forbes SC, Cordingley DM, Cornish SM, Gualano B, Roschel H, Ostojic SM, et al. Effects of Creatine Supplementation on Brain Function and Health. Nutrients 2022;14(5):921 View Article PubMed/NCBI
  7. Pardo E, Constantin JM, Bonnet F, Verdonk F. Nutritional support for critically ill patients with COVID-19: New strategy for a new disease?. Anaesth Crit Care Pain Med 2020;39(6):738-739 View Article PubMed/NCBI
  8. Pahlavan N. Current Nutritional Support in Critical Ill Covid-19 Patients: A Brief Review. Austin Crit Care 2021;8(1):1034 View Article
  9. Charrueau C, Belabed L, Besson V, Chaumeil JC, Cynober L, Moinard C. Metabolic response and nutritional support in traumatic brain injury: evidence for resistance to renutrition. J Neurotrauma 2009;26(11):1911-1920 View Article PubMed/NCBI
  10. Wischmeyer PE. Nutrition Therapy in Sepsis. Crit Care Clin 2018;34(1):107-125 View Article PubMed/NCBI
  11. Burgos Pelaez R, Segurola Gurrutxaga H, Breton Lesmes I. Nutritional support in stroke patients. Nutr Hosp 2014;29(Suppl 2):57-66 PubMed/NCBI
  12. Caliri S, Andaloro A, Corallo F, Donato A, Marino S, Mantarro C, et al. Recovery of malnutrition in a patient with severe brain injury outcomes: A case report. Medicine (Baltimore) 2019;98(40):e16755 View Article PubMed/NCBI
  13. Chapple LS, Deane AM, Williams LT, Strickland R, Schultz C, Lange K, et al. Longitudinal changes in anthropometrics and impact on self-reported physical function after traumatic brain injury. Crit Care Resusc 2017;19(1):29-36 PubMed/NCBI
  14. Lauren R, Ford JRO. A Descriptive Study of Malnutrition in Traumatic Brain Injury Patients. Panamerican Journal of Trauma, Critical Care & Emergency Surgery 2021;10(3):107-112 View Article
  15. Dijkink S, Meier K, Krijnen P, Yeh DD, Velmahos GC, Schipper IB. Malnutrition and its effects in severely injured trauma patients. Eur J Trauma Emerg Surg 2020;46(5):993-1004 View Article PubMed/NCBI
  16. Costello LA, Lithander FE, Gruen RL, Williams LT. Nutrition therapy in the optimisation of health outcomes in adult patients with moderate to severe traumatic brain injury: Findings from a scoping review. Injury 2014;45(12):1834-1841 View Article PubMed/NCBI
  17. Ng SY, Lee AYW. Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets. Front Cell Neurosci 2019;13:528 View Article PubMed/NCBI
  18. Kurtz P, Rocha EEM. Nutrition Therapy, Glucose Control, and Brain Metabolism in Traumatic Brain Injury: A Multimodal Monitoring Approach. Front Neurosci 2020;14:190 View Article PubMed/NCBI
  19. Foley N, Marshall S, Pikul J, Salter K, Teasell R. Hypermetabolism following moderate to severe traumatic acute brain injury: a systematic review. J Neurotrauma 2008;25(12):1415-1431 View Article PubMed/NCBI
  20. Twyman D. Nutritional management of the critically ill neurologic patient. Crit Care Clin 1997;13(1):39-49 View Article PubMed/NCBI
  21. Institute of Medicine (US) Committee on Nutrition, Trauma, and the Brain. Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel. Washington, DC: National Academies Press (US); 2011 View Article PubMed/NCBI
  22. Bistrian BR, Askew W, Erdman JW, Oria MP. Nutrition and traumatic brain injury: a perspective from the Institute of Medicine report. JPEN J Parenter Enteral Nutr 2011;35(5):556-559 View Article PubMed/NCBI
  23. Perel P, Yanagawa T, Bunn F, Roberts I, Wentz R, Pierro A. Nutritional support for head-injured patients. Cochrane Database Syst Rev 2006;2006(4):Cd001530 View Article PubMed/NCBI
  24. Wang X, Dong Y, Han X, Qi XQ, Huang CG, Hou LJ. Nutritional support for patients sustaining traumatic brain injury: a systematic review and meta-analysis of prospective studies. PLoS One 2013;8(3):e58838 View Article PubMed/NCBI
  25. Carney N, Totten AM, O’Reilly C, Ullman JS, Hawryluk GW, Bell MJ, et al. Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery 2017;80(1):6-15 View Article PubMed/NCBI
  26. Hartl R, Gerber LM, Ni Q, Ghajar J. Effect of early nutrition on deaths due to severe traumatic brain injury. J Neurosurg 2008;109(1):50-56 View Article PubMed/NCBI
  27. Howlett JR, Nelson LD, Stein MB. Mental Health Consequences of Traumatic Brain Injury. Biol Psychiatry 2022;91(5):413-420 View Article PubMed/NCBI
  28. Cook AM, Peppard A, Magnuson B. Nutrition considerations in traumatic brain injury. Nutr Clin Pract 2008;23(6):608-620 View Article PubMed/NCBI
  29. Rostami E. Glucose and the injured brain-monitored in the neurointensive care unit. Front Neurol 2014;5:91 View Article PubMed/NCBI
  30. Shi J, Dong B, Mao Y, Guan W, Cao J, Zhu R, et al. Review: Traumatic brain injury and hyperglycemia, a potentially modifiable risk factor. Oncotarget 2016;7(43):71052-71061 View Article PubMed/NCBI
  31. Sekar S, Viswas RS, Miranzadeh Mahabadi H, Alizadeh E, Fonge H, Taghibiglou C. Concussion/Mild Traumatic Brain Injury (TBI) Induces Brain Insulin Resistance: A Positron Emission Tomography (PET) Scanning Study. Int J Mol Sci 2021;22(16):9005 View Article PubMed/NCBI
  32. Shaughness M, Acs D, Brabazon F, Hockenbury N, Byrnes KR. Role of Insulin in Neurotrauma and Neurodegeneration: A Review. Front Neurosci 2020;14:547175 View Article PubMed/NCBI
  33. Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr 2019;38(1):48-79 View Article PubMed/NCBI
  34. Bilotta F, Caramia R, Cernak I, Paoloni FP, Doronzio A, Cuzzone V, et al. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit Care 2008;9(2):159-166 View Article PubMed/NCBI
  35. Oddo M, Schmidt JM, Carrera E, Badjatia N, Connolly ES, Presciutti M, et al. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: A microdialysis study. Crit Care Med 2008;36(12):3233-3238 View Article PubMed/NCBI
  36. Vespa P, McArthur DL, Stein N, Huang SC, Shao W, Filippou M, et al. Tight glycemic control increases metabolic distress in traumatic brain injury: a randomized controlled within-subjects trial. Crit Care Med 2012;40(6):1923-1929 View Article PubMed/NCBI
  37. Bechir M, Meierhans R, Brandi G, Sommerfeld J, Fasshauer M, Cottini SR, et al. Insulin differentially influences brain glucose and lactate in traumatic brain injured patients. Minerva Anestesiol 2010;76(11):896-904 PubMed/NCBI
  38. Meierhans R, Bechir M, Ludwig S, Sommerfeld J, Brandi G, Haberthur C, et al. Brain metabolism is significantly impaired at blood glucose below 6 mM and brain glucose below 1 mM in patients with severe traumatic brain injury. Crit Care 2010;14(1):R13 View Article PubMed/NCBI
  39. Singer P, Anbar R, Cohen J, Shapiro H, Shalita-Chesner M, Lev S, et al. The tight calorie control study (TICACOS): A prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med 2011;37(4):601-609 View Article PubMed/NCBI
  40. Young B, Ott L, Yingling B, McClain C. Nutrition and brain injury. J Neurotrauma 1992;9(Suppl 1):S375-383 PubMed/NCBI
  41. Clifton GL, Robertson CS, Contant CF. Enteral hyperalimentation in head injury. J Neurosurg 1985;62(2):186-193 View Article PubMed/NCBI
  42. Young B, Ott L, Norton J, Tibbs P, Rapp R, McClain C, et al. Metabolic and nutritional sequelae in the non-steroid treated head injury patient. Neurosurgery 1985;17(5):784-791 View Article PubMed/NCBI
  43. Young B, Ott L, Twyman D, Norton J, Rapp R, Tibbs P, et al. The effect of nutritional support on outcome from severe head injury. J Neurosurg 1987;67(5):668-676 View Article PubMed/NCBI
  44. de Aguilar-Nascimento JE, Kudsk KA. Clinical costs of feeding tube placement. JPEN J Parenter Enteral Nutr 2007;31(4):269-273 View Article PubMed/NCBI
  45. Hatton J, Rapp RP, Kudsk KA, Brown RO, Luer MS, Bukar JG, et al. Intravenous insulin-like growth factor-I (IGF-I) in moderate-to-severe head injury: A Phase II safety and efficacy trial. Neurosurg Focus 1997;2(5):ECP1 PubMed/NCBI
  46. Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, et al. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med 1999;341(11):785-792 View Article PubMed/NCBI
  47. Ruokonen E, Takala J. Dangers of growth hormone therapy in critically ill patients. Curr Opin Clin Nutr Metab Care 2002;5(2):199-209 View Article PubMed/NCBI
  48. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993;34(2):216-222 View Article PubMed/NCBI
  49. Rauch S, Marzolo M, Cappello TD, Strohle M, Mair P, Pietsch U, et al. Severe traumatic brain injury and hypotension is a frequent and lethal combination in multiple trauma patients in mountain areas - an analysis of the prospective international Alpine Trauma Registry. Scand J Trauma Resusc Emerg Med 2021;29(1):61 View Article PubMed/NCBI
  50. Berry C, Ley EJ, Bukur M, Malinoski D, Margulies DR, Mirocha J, et al. Redefining hypotension in traumatic brain injury. Injury 2012;43(11):1833-1837 View Article PubMed/NCBI
  51. Sundstrøm T, Grände PO, Luoto T, Rosenlund C, Undén J, Wester KG. Management of Severe Traumatic Brain Injury. Cham: Springer; 2020 View Article
  52. The SAFE Study Investigators. Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med 2007;357(9):874-884 View Article PubMed/NCBI
  53. Young B, Ott L, Dempsey R, Haack D, Tibbs P. Relationship between admission hyperglycemia and neurologic outcome of severely brain-injured patients. Ann Surg 1989;210(4):466-472 View Article PubMed/NCBI
  54. Hariri RJ, Firlick AD, Shepard SR, Cohen DS, Barie PS, Emery JM, et al. Traumatic brain injury, hemorrhagic shock, and fluid resuscitation: effects on intracranial pressure and brain compliance. J Neurosurg 1993;79(3):421-427 View Article PubMed/NCBI
  55. Robertson CS, Valadka AB, Hannay HJ, Contant CF, Gopinath SP, Cormio M, et al. Prevention of secondary ischemic insults after severe head injury. Crit Care Med 1999;27(10):2086-2095 View Article PubMed/NCBI
  56. Dhandapani M, Dhandapani S, Agarwal M, Mahapatra AK. Pressure ulcer in patients with severe traumatic brain injury: significant factors and association with neurological outcome. J Clin Nurs 2014;23(7-8):1114-1119 View Article PubMed/NCBI
  57. Skillman HE, Mehta NM. Nutrition therapy in the critically ill child. Curr Opin Crit Care 2012;18(2):192-198 View Article PubMed/NCBI
  58. Kelly DA. Liver complications of pediatric parenteral nutrition—epidemiology. Nutrition 1998;14(1):153-157 View Article PubMed/NCBI
  59. Kattelmann KK, Hise M, Russell M, Charney P, Stokes M, Compher C. Preliminary evidence for a medical nutrition therapy protocol: enteral feedings for critically ill patients. J Am Diet Assoc 2006;106(8):1226-1241 View Article PubMed/NCBI
  60. Rhoney DH, Parker D, Formea CM, Yap C, Coplin WM. Tolerability of bolus versus continuous gastric feeding in brain-injured patients. Neurol Res 2002;24(6):613-620 View Article PubMed/NCBI
  61. Boivin MA, Levy H. Gastric feeding with erythromycin is equivalent to transpyloric feeding in the critically ill. Crit Care Med 2001;29(10):1916-1919 View Article PubMed/NCBI
  62. Fraser RJ, Bryant L. Current and future therapeutic prokinetic therapy to improve enteral feed intolerance in the ICU patient. Nutr Clin Pract 2010;25(1):26-31 View Article PubMed/NCBI
  63. Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P, Canadian Critical Care Clinical Practice Guidelines Committee. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr 2003;27(5):355-73 View Article PubMed/NCBI
  64. Grahm TW, Zadrozny DB, Harrington T. The benefits of early jejunal hyperalimentation in the head-injured patient. Neurosurgery 1989;25(5):729-735 View Article PubMed/NCBI
  65. Webster J, Osborne S, Rickard CM, Marsh N. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev 2019;1(1):CD007798 View Article PubMed/NCBI
  66. Li X, Yang Y, Ma ZF, Gao S, Ning Y, Zhao L, et al. Enteral combined with parenteral nutrition improves clinical outcomes in patients with traumatic brain injury. Nutr Neurosci 2022;25(3):530-536 View Article PubMed/NCBI
  67. Vonder Haar C, Peterson TC, Martens KM, Hoane MR. Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies. Brain Res 2016;1640:114-129 View Article PubMed/NCBI
  68. Baracaldo-Santamaria D, Ariza-Salamanca DF, Corrales-Hernandez MG, Pachon-Londono MJ, Hernandez-Duarte I, Calderon-Ospina CA. Revisiting Excitotoxicity in Traumatic Brain Injury: From Bench to Bedside. Pharmaceutics 2022;14(1):152 View Article PubMed/NCBI
  69. Hummel R, Ulbrich S, Appel D, Li S, Hirnet T, Zander S, et al. Administration of all-trans retinoic acid after experimental traumatic brain injury is brain protective. Br J Pharmacol 2020;177(22):5208-5223 View Article PubMed/NCBI
  70. Hoane MR, Wolyniak JG, Akstulewicz SL. Administration of riboflavin improves behavioral outcome and reduces edema formation and glial fibrillary acidic protein expression after traumatic brain injury. J Neurotrauma 2005;22(10):1112-1122 View Article PubMed/NCBI
  71. Barbre AB, Hoane MR. Magnesium and riboflavin combination therapy following cortical contusion injury in the rat. Brain Res Bull 2006;69(6):639-646 View Article PubMed/NCBI
  72. Ameliorate JL, Ghabriel MN, Vink R. Magnesium enhances the beneficial effects of NK1 antagonist administration on blood-brain barrier permeability and motor outcome after traumatic brain injury. Magnes Res 2017;30(3):88-97 View Article PubMed/NCBI
  73. Standiford L, O’Daniel M, Hysell M, Trigger C. A randomized cohort study of the efficacy of PO magnesium in the treatment of acute concussions in adolescents. Am J Emerg Med 2021;44:419-422 View Article PubMed/NCBI
  74. Temkin NR, Anderson GD, Winn HR, Ellenbogen RG, Britz GW, Schuster J, et al. Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol 2007;6(1):29-38 View Article PubMed/NCBI
  75. Li W, Bai YA, Li YJ, Liu KG, Wang MD, Xu GZ, et al. Magnesium sulfate for acute traumatic brain injury. J Craniofac Surg 2015;26(2):393-398 View Article PubMed/NCBI
  76. Hoane MR, Akstulewicz SL, Toppen J. Treatment with vitamin B3 improves functional recovery and reduces GFAP expression following traumatic brain injury in rats. J Neurotrauma 2003;20(11):1189-1199 View Article PubMed/NCBI
  77. Hoane MR, Gilbert DR, Holland MA, Pierce JL. Nicotinamide reduces acute cortical neuronal death and edema in the traumatically injured brain. Neurosci Lett 2006;408(1):35-39 View Article PubMed/NCBI
  78. Hoane MR, Pierce JL, Holland MA, Anderson GD. Nicotinamide treatment induces behavioral recovery when administered up to 4 hours following cortical contusion injury in the rat. Neuroscience 2008;154(3):861-868 View Article PubMed/NCBI
  79. Peterson TC, Hoane MR, McConomy KS, Farin FM, Bammler TK, MacDonald JW, et al. A Combination Therapy of Nicotinamide and Progesterone Improves Functional Recovery following Traumatic Brain Injury. J Neurotrauma 2015;32(11):765-779 View Article PubMed/NCBI
  80. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy-A Review. Nutrients 2016;8(2):68 View Article PubMed/NCBI
  81. Shen J, Lai CQ, Mattei J, Ordovas JM, Tucker KL. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am J Clin Nutr 2010;91(2):337-342 View Article PubMed/NCBI
  82. Kuypers NJ, Hoane MR. Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat. J Neurotrauma 2010;27(7):1275-1282 View Article PubMed/NCBI
  83. Smithells RW, Sheppard S, Schorah CJ. Vitamin deficiencies and neural tube defects. Arch Dis Child 1976;51(12):944-950 View Article PubMed/NCBI
  84. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327(26):1832-1835 View Article PubMed/NCBI
  85. Ho PI, Ashline D, Dhitavat S, Ortiz D, Collins SC, Shea TB, et al. Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol Dis 2003;14(1):32-42 View Article PubMed/NCBI
  86. Reynolds EH. Folic acid, ageing, depression, and dementia. BMJ 2002;324(7352):1512-1515 View Article PubMed/NCBI
  87. Van Guelpen B, Hultdin J, Johansson I, Stegmayr B, Hallmans G, Nilsson TK, et al. Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke: A prospective, nested case-referent study of plasma concentrations and dietary intake. Stroke 2005;36(7):1426-1431 View Article PubMed/NCBI
  88. Naim MY, Friess S, Smith C, Ralston J, Ryall K, Helfaer MA, et al. Folic acid enhances early functional recovery in a piglet model of pediatric head injury. Dev Neurosci 2010;32(5-6):466-479 View Article PubMed/NCBI
  89. Vonder Haar C, Emery MA, Hoane MR. Chronic folic acid administration confers no treatment effects in either a high or low dose following unilateral controlled cortical impact injury in the rat. Restor Neurol Neurosci 2012;30(4):291-302 View Article PubMed/NCBI
  90. Health Quality O. Vitamin B12 and cognitive function: an evidence-based analysis. Ont Health Technol Assess Ser 2013;13(23):1-45 PubMed/NCBI
  91. Wu F, Xu K, Liu L, Zhang K, Xia L, Zhang M, et al. Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury. Front Pharmacol 2019;10:406 View Article PubMed/NCBI
  92. Grunewald RA. Ascorbic acid in the brain. Brain Res Brain Res Rev 1993;18(1):123-133 View Article PubMed/NCBI
  93. Rice ME. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci 2000;23(5):209-216 View Article PubMed/NCBI
  94. Awasthi D, Church DF, Torbati D, Carey ME, Pryor WA. Oxidative stress following traumatic brain injury in rats. Surg Neurol 1997;47(6):575-581 View Article PubMed/NCBI
  95. Ishaq GM, Saidu Y, Bilbis LS, Muhammad SA, Jinjir N, Shehu BB. Effects of alpha-tocopherol and ascorbic acid in the severity and management of traumatic brain injury in albino rats. J Neurosci Rural Pract 2013;4(3):292-297 View Article PubMed/NCBI
  96. Wang KW, Wang HK, Chen HJ, Liliang PC, Liang CL, Tsai YD, et al. Simvastatin combined with antioxidant attenuates the cerebral vascular endothelial inflammatory response in a rat traumatic brain injury. Biomed Res Int 2014;2014:910260 View Article PubMed/NCBI
  97. Tang H, Hua F, Wang J, Yousuf S, Atif F, Sayeed I, et al. Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury. Brain Inj 2015;29(10):1165-1174 View Article PubMed/NCBI
  98. Cekic M, Cutler SM, VanLandingham JW, Stein DG. Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats. Neurobiol Aging 2011;32(5):864-874 View Article PubMed/NCBI
  99. Arabi SM, Sedaghat A, Ehsaei MR, Safarian M, Ranjbar G, Rezaee H, et al. Efficacy of high-dose versus low-dose vitamin D supplementation on serum levels of inflammatory factors and mortality rate in severe traumatic brain injury patients: study protocol for a randomized placebo-controlled trial. Trials 2020;21(1):685 View Article PubMed/NCBI
  100. Singh PK, Krishnan S. Vitamin E Analogs as Radiation Response Modifiers. Evid Based Complement Alternat Med 2015;2015:741301 View Article PubMed/NCBI
  101. Mariani E, Polidori MC, Cherubini A, Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 2005;827(1):65-75 View Article PubMed/NCBI
  102. Aiguo W, Zhe Y, Gomez-Pinilla F. Vitamin E protects against oxidative damage and learning disability after mild traumatic brain injury in rats. Neurorehabil Neural Repair 2010;24(3):290-298 View Article PubMed/NCBI
  103. Inci S, Ozcan OE, Kilinc K. Time-level relationship for lipid peroxidation and the protective effect of alpha-tocopherol in experimental mild and severe brain injury. Neurosurgery 1998;43(2):330-335 View Article PubMed/NCBI
  104. Conte V, Uryu K, Fujimoto S, Yao Y, Rokach J, Longhi L, et al. Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury. J Neurochem 2004;90(3):758-764 View Article PubMed/NCBI
  105. Hellmich HL, Eidson KA, Capra BA, Garcia JM, Boone DR, Hawkins BE, et al. Injured Fluoro-Jade-positive hippocampal neurons contain high levels of zinc after traumatic brain injury. Brain Res 2007;1127(1):119-126 View Article PubMed/NCBI
  106. Suh SW, Chen JW, Motamedi M, Bell B, Listiak K, Pons NF, et al. Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury. Brain Res 2000;852(2):268-273 View Article PubMed/NCBI
  107. McClain CJ, Twyman DL, Ott LG, Rapp RP, Tibbs PA, Norton JA, et al. Serum and urine zinc response in head-injured patients. J Neurosurg 1986;64(2):224-230 View Article PubMed/NCBI
  108. Cope EC, Morris DR, Scrimgeour AG, VanLandingham JW, Levenson CW. Zinc supplementation provides behavioral resiliency in a rat model of traumatic brain injury. Physiol Behav 2011;104(5):942-947 View Article PubMed/NCBI
  109. Kurien M, McAlindon ME, Westaby D, Sanders DS. Percutaneous endoscopic gastrostomy (PEG) feeding. BMJ 2010;340:c2414 View Article PubMed/NCBI
  110. Senol N, Naziroglu M, Yuruker V. N-acetylcysteine and selenium modulate oxidative stress, antioxidant vitamin and cytokine values in traumatic brain injury-induced rats. Neurochem Res 2014;39(4):685-692 View Article PubMed/NCBI
  111. Moghaddam OM, Lahiji MN, Hassani V, Mozari S. Early Administration of Selenium in Patients with Acute Traumatic Brain Injury: A Randomized Double-blinded Controlled Trial. Indian J Crit Care Med 2017;21(2):75-79 View Article PubMed/NCBI
  112. Khalili H, Ahl R, Cao Y, Paydar S, Sjolin G, Niakan A, et al. Early selenium treatment for traumatic brain injury: Does it improve survival and functional outcome?. Injury 2017;48(9):1922-1926 View Article PubMed/NCBI
  113. Ainsley Dean PJ, Arikan G, Opitz B, Sterr A. Potential for use of creatine supplementation following mild traumatic brain injury. Concussion 2017;2(2):CNC34 View Article PubMed/NCBI
  114. Hall M, Manetta E, Tupper K. Creatine Supplementation: An Update. Curr Sports Med Rep 2021;20(7):338-344 View Article PubMed/NCBI
  115. Roschel H, Gualano B, Ostojic SM, Rawson ES. Creatine Supplementation and Brain Health. Nutrients 2021;13(2):586 View Article PubMed/NCBI
  116. Sakellaris G, Nasis G, Kotsiou M, Tamiolaki M, Charissis G, Evangeliou A. Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study. Acta Paediatr 2008;97(1):31-34 View Article PubMed/NCBI
  117. Sullivan PG, Geiger JD, Mattson MP, Scheff SW. Dietary supplement creatine protects against traumatic brain injury. Ann Neurol 2000;48(5):723-729 PubMed/NCBI
  118. Wu A, Ying Z, Gomez-Pinilla F. The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. J Neurotrauma 2011;28(10):2113-2122 View Article PubMed/NCBI
  119. Bailes JE, Mills JD. Docosahexaenoic acid reduces traumatic axonal injury in a rodent head injury model. J Neurotrauma 2010;27(9):1617-1624 View Article PubMed/NCBI
  120. Lien EL. Toxicology and safety of DHA. Prostaglandins Leukot Essent Fatty Acids 2009;81(2-3):125-132 View Article PubMed/NCBI
  121. Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol 2006;197(2):309-317 View Article PubMed/NCBI
  122. Gatson JW, Liu MM, Abdelfattah K, Wigginton JG, Smith S, Wolf S, et al. Resveratrol decreases inflammation in the brain of mice with mild traumatic brain injury. J Trauma Acute Care Surg 2013;74(2):470-475 View Article PubMed/NCBI
  123. Zou P, Liu X, Li G, Wang Y. Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1. Mol Med Rep 2018;17(2):3212-3217 View Article PubMed/NCBI
  124. Kwon KJ, Kim JN, Kim MK, Lee J, Ignarro LJ, Kim HJ, et al. Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. J Pineal Res 2011;50(2):110-123 View Article PubMed/NCBI
  125. Shand B, Strey C, Scott R, Morrison Z, Gieseg S. Pilot study on the clinical effects of dietary supplementation with Enzogenol, a flavonoid extract of pine bark and vitamin C. Phytother Res 2003;17(5):490-494 View Article PubMed/NCBI
  126. Theadom A, Mahon S, Barker-Collo S, McPherson K, Rush E, Vandal AC, et al. Enzogenol for cognitive functioning in traumatic brain injury: a pilot placebo-controlled RCT. Eur J Neurol 2013;20(8):1135-1144 View Article PubMed/NCBI
  127. Dash PK, Zhao J, Orsi SA, Zhang M, Moore AN. Sulforaphane improves cognitive function administered following traumatic brain injury. Neurosci Lett 2009;460(2):103-107 View Article PubMed/NCBI
  128. Lee DC, Lau AS. Effects of Panax ginseng on tumor necrosis factor-alpha-mediated inflammation: a mini-review. Molecules 2011;16(4):2802-2816 View Article PubMed/NCBI
  129. Hu BY, Liu XJ, Qiang R, Jiang ZL, Xu LH, Wang GH, et al. Treatment with ginseng total saponins improves the neurorestoration of rat after traumatic brain injury. J Ethnopharmacol 2014;155(2):1243-1255 View Article PubMed/NCBI
  130. Xia L, Jiang ZL, Wang GH, Hu BY, Ke KF. Treatment with ginseng total saponins reduces the secondary brain injury in rat after cortical impact. J Neurosci Res 2012;90(7):1424-1436 View Article PubMed/NCBI
  131. Ji X, Peng D, Zhang Y, Zhang J, Wang Y, Gao Y, et al. Astaxanthin improves cognitive performance in mice following mild traumatic brain injury. Brain Res 2017;1659:88-95 View Article PubMed/NCBI
  132. Senol N, Naziroglu M. Melatonin reduces traumatic brain injury-induced oxidative stress in the cerebral cortex and blood of rats. Neural Regen Res 2014;9(11):1112-1116 View Article PubMed/NCBI
  133. Hoffer ME, Balaban C, Slade MD, Tsao JW, Hoffer B. Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study. PLoS One 2013;8(1):e54163 View Article PubMed/NCBI
  134. Malekahmadi M, Moradi Moghaddam O, Firouzi S, Daryabeygi-Khotbehsara R, Shariful Islam SM, Norouzy A, et al. Effects of pycnogenol on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2019;150:104472 View Article PubMed/NCBI
  135. Ansari MA, Keller JN, Scheff SW. Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity. Free Radic Biol Med 2008;45(11):1510-1519 View Article PubMed/NCBI
  136. Peng QL, Buz’Zard AR, Lau BH. Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis. Brain Res Mol Brain Res 2002;104(1):55-65 View Article PubMed/NCBI
  137. Sahebkar A. A systematic review and meta-analysis of the effects of pycnogenol on plasma lipids. J Cardiovasc Pharmacol Ther 2014;19(3):244-255 View Article PubMed/NCBI
  138. Hadi A, Pourmasoumi M, Mohammadi H, Javaheri A, Rouhani MH. The impact of pycnogenol supplementation on plasma lipids in humans: A systematic review and meta-analysis of clinical trials. Phytother Res 2019;33(2):276-287 View Article PubMed/NCBI
  139. Malekahmadi M, Moradi Moghaddam O, Islam SMS, Tanha K, Nematy M, Pahlavani N, et al. Evaluation of the effects of pycnogenol (French maritime pine bark extract) supplementation on inflammatory biomarkers and nutritional and clinical status in traumatic brain injury patients in an intensive care unit: A randomized clinical trial protocol. Trials 2020;21(1):162 View Article PubMed/NCBI
  140. Scheff SW, Ansari MA, Roberts KN. Neuroprotective effect of Pycnogenol(R) following traumatic brain injury. Exp Neurol 2013;239:183-191 View Article PubMed/NCBI
Copyright © 2023 Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • Exploratory Research and Hypothesis in Medicine
  • pISSN 2993-5113
  • eISSN 2472-0712

Article Options

Metrics

Cite this Article

  • © 2024 Xia & He Publishing Inc.
  • Total visits : 1954984
  • Visits today : 337
Back to Top

Nutritional Support Following Traumatic Brain Injury: A Comprehensive Review

Divine Nwafor, Joel Goeckeritz, Zahra Hasanpour, Caroline Davidson, Brandon Lucke-Wold
  • Reset Zoom
  • Download TIFF