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JCTH Highly Cited Articles 2024-2025
Review Article Open Access
The Role of Hepatic SIRT1: From Metabolic Regulation to Immune Modulation and Multi-target Therapeutic Strategies
Houyan Zhang, Dongjie Wu, Qingjuan Wu, Yanxuan Wu, Ziwei Guo, Li Wang, Yi Wang, Qian Zeng, Liang Shi, Bin Shi, Gongchang Yu, Wenliang Lv
Journal of Clinical and Translational Hepatology, Published online September 3, 2025. doi:10.14218/JCTH.2025.00259
Original Article Open Access
Mapping Metabolic Dysfunction-associated Steatotic Liver Disease Models of Care across 17 Middle East and North Africa Countries: Insights into Guidelines, Infrastructure, and Referral Systems
Mohamed El-Kassas, Khalid M. AlNaamani, Rofida Khalifa, Yusuf Yilmaz, Asma Labidi, Maen Almattooq, Faisal M. Sanai, Maisam W.I. Akroush Nabil Debzi, Mohammed A. Medhat, Imam Waked, Ali Tumi, Mohamed Elbadry, Mohammed Omer Mohammed, Ala I. Sharara, Ali El Houni, Mohamed Alsenbesy, Hisham El-Khayat, Mina Tharwat, Abdel-Naser Elzouki, Khalid A. Alswat, Zobair M. Younossi, on behalf of the Steatotic Liver Disease Study Foundation in Middle East and North Africa (SLMENA) Collaborators
Journal of Clinical and Translational Hepatology, Published online September 1, 2025. doi:10.14218/JCTH.2025.00286
Review Article Open Access
Targeting Glypican-3 for Liver Cancer Therapy: Clinical Applications and Detection Methods
Jin Zhang, Rong Li, Xueqin Tan, Chuang Wang
Journal of Clinical and Translational Hepatology, Published online August 7, 2025. doi:10.14218/JCTH.2025.00099
Review Article Open Access
Exploring the Therapeutic Potential of TGF-β Inhibitors for Liver Fibrosis: Targeting Multiple Signaling Pathways
Wanchun Zhu, Yu Cui, Jiahao Qiu, Xin Zhang, Yueqiu Gao, Zhi Shang, Lingying Huang
Journal of Clinical and Translational Hepatology, Published online July 15, 2025. doi:10.14218/JCTH.2025.00029
Review Article Open Access
Hepatocellular Carcinoma and the Role of Liver Transplantation: An Update and Review
Lynette M. Sequeira, N. Begum Ozturk, Leandro Sierra, Merve Gurakar, Merih Deniz Toruner, Melanie Zheng, Cem Simsek, Ahmet Gurakar, Amy K. Kim
Journal of Clinical and Translational Hepatology, Published online February 24, 2025. doi:10.14218/JCTH.2024.00432
Guideline Open Access
Chinese Guidelines on the Management of Hepatic Encephalopathy in Cirrhosis (2024)
Xiaoyuan Xu, Huiguo Ding, Wengang Li, Ying Han, Yujuan Guan, Jinghang Xu, Yifan Han, Jidong Jia, Lai Wei, Zhongping Duan, Yuemin Nan, Hui Zhuang, Chinese Society of Hepatology, Chinese Medical Association
Journal of Clinical and Translational Hepatology, Published online February 17, 2025. doi:10.14218/JCTH.2024.00484
Mini Review Open Access
Ursodeoxycholic Acid for the Management of Drug-induced Liver Injury: Role of Hepatoprotective and Anti-cholestatic Mechanisms
Fernando Bessone, Geraldine L. Hillotte, Norberto Tamagnone, Daiana Arnedillo, Marcelo G. Roma
Journal of Clinical and Translational Hepatology, Published online January 21, 2025. doi:10.14218/JCTH.2024.00325
Original Article Open Access
Risk of Coronary Artery Disease in Patients with Liver Cirrhosis: A Systematic Review and Meta-analysis
Chunru Gu, Liyan Dong, Lu Chai, Zhenhua Tong, Fangbo Gao, Walter Ageno, Fernando Gomes Romeiro, Xingshun Qi
Journal of Clinical and Translational Hepatology, Published online November 21, 2024. doi:10.14218/JCTH.2024.00226
Review Article Open Access
The Development and Appraisal of MELD 3.0 in Liver Diseases: Good Things Never Come Easy
Gaoyue Guo, Wanting Yang, Jia Li, Ziyi Yang, Jing Liang, Chao Sun
Journal of Clinical and Translational Hepatology, Published online November 12, 2024. doi:10.14218/JCTH.2024.00303
Guideline Open Access
Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024)
Jian-Gao Fan, Xiao-Yuan Xu, Rui-Xu Yang, Yue-Min Nan, Lai Wei, Ji-Dong Jia, Hui Zhuang, Jun-Ping Shi, Xiao-Ying Li, Chao Sun, Jie Li, Vincent Wai-Sun Wong, Zhong-Ping Duan, Chinese Society of Hepatology, Chinese Medical Association
Journal of Clinical and Translational Hepatology, Published online November 4, 2024. doi:10.14218/JCTH.2024.00311
Review Article Open Access
Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective
Hartmut Jaeschke, Anup Ramachandran
Journal of Clinical and Translational Hepatology, Published online October 29, 2024. doi:10.14218/JCTH.2024.00324
Review Article Open Access
The Multifaceted Role of Bilirubin in Liver Disease: A Literature Review
Mariana M. Ramírez-Mejía, Stephany M. Castillo-Castañeda, Shreya C. Pal, Xingshun Qi, Nahum Méndez-Sánchez
Journal of Clinical and Translational Hepatology, Published online October 21, 2024. doi:10.14218/JCTH.2024.00156
Review Article Open Access
Mechanism of Metabolic Dysfunction-associated Steatotic Liver Disease: Important role of lipid metabolism
Xiaoxi Feng, Rutong Zhang, Zhenye Yang, Kaiguang Zhang, Jun Xing
Journal of Clinical and Translational Hepatology, Published online September 3, 2024. doi:10.14218/JCTH.2024.00019
Review Article Open Access
Pipeline of New Drug Treatment for Non-alcoholic Fatty Liver Disease/Metabolic Dysfunction-associated Steatotic Liver Disease
Ye Hu, Chao Sun, Ying Chen, Yu-Dong Liu, Jian-Gao Fan
Journal of Clinical and Translational Hepatology, Published online July 31, 2024. doi:10.14218/JCTH.2024.00123
Review Article Open Access
Bacterial Infections in Acute-on-chronic Liver Failure: Epidemiology, Diagnosis, Pathogenesis, and Management
Zhaoyu Xu, Xiuding Zhang, Jiyang Chen, Yu Shi, Shangwei Ji
Journal of Clinical and Translational Hepatology, Published online June 20, 2024. doi:10.14218/JCTH.2024.00137
Review Article Open Access
Ultrasonography of Hepatocellular Carcinoma: From Diagnosis to Prognosis
Huisen Hu, Yonglei Zhao, Chengbin He, Lujie Qian, Pintong Huang
Journal of Clinical and Translational Hepatology, Published online April 30, 2024. doi:10.14218/JCTH.2024.00018
Original Article Open Access
Mortality Burden of Liver Cancer in China: An Observational Study From 2008 to 2020
Huixin Liu, Xiaoxiao Wang, Lijun Wang, Peng Yin, Feng Liu, Lai Wei, Yu Wang, Maigeng Zhou, Jinlei Qi, Huiying Rao
Journal of Clinical and Translational Hepatology, Published online March 19, 2024. doi:10.14218/JCTH.2023.00455
Review Article Open Access
Subnormal Serum Liver Enzyme Levels: A Review of Pathophysiology and Clinical Significance
Elham M. Youssef, George Y. Wu
Journal of Clinical and Translational Hepatology, Published online March 18, 2024. doi:10.14218/JCTH.2023.00446
Review Article Open Access
Treatment Options for Hepatocellular Carcinoma Using Immunotherapy: Present and Future
Hongbin Wei, Chunlu Dong, Xun Li
Journal of Clinical and Translational Hepatology, Published online February 28, 2024. doi:10.14218/JCTH.2023.00462
Review Article Open Access
Genetics of Gallstone Disease and Their Clinical Significance: A Narrative Review
Christopher J. Costa, Minh Thu T. Nguyen, Haleh Vaziri, George Y. Wu
Journal of Clinical and Translational Hepatology, Published online February 8, 2024. doi:10.14218/JCTH.2023.00563
Review Article Open Access
Progress in Biomarkers Related to Biliary Atresia
Fanyang Kong, Rui Dong, Gong Chen, Song Sun, Yifan Yang, Jingying Jiang, Lingdu Meng, Huifen Chen, Jiajie Zhu, Shan Zheng
Journal of Clinical and Translational Hepatology, Published online January 30, 2024. doi:10.14218/JCTH.2023.00260
Review Article Open Access
Improving the Conversion Success Rate of Hepatocellular Carcinoma: Focus on the Use of Combination Therapy with a High Objective Response Rate
Qi-Feng Chen, Song Chen, Minshan Chen, Ning Lyu, Ming Zhao
Journal of Clinical and Translational Hepatology, Published online January 10, 2024. doi:10.14218/JCTH.2023.00403
Original Article Open Access
Hepatocellular Carcinoma Incidence and Mortality in the USA by Sex, Age, and Race: A Nationwide Analysis of Two Decades
Yazan Abboud, Mohamed Ismail, Hamza Khan, Esli Medina-Morales, Saqr Alsakarneh, Fouad Jaber, Nikolaos T. Pyrsopoulos
Journal of Clinical and Translational Hepatology, Published online January 2, 2024. doi:10.14218/JCTH.2023.00356
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