Network Pharmacology Analysis of the Mechanism of Action of Paederia scandens in the Treatment of NAFLD
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Hui Zhu1,
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Ming-Zhong Xiao1,2 and
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Xiao-Dong Li1,2,*
Author information
Hubei University of Chinese Medicine, Wuhan, 430065, China
Hubei Hospital of Traditional Chinese Medicine, Wuhan, 430061, China
Correspondence to: Xiao-Dong Li, Hubei University of Chinese Medicine, Wuhan, 430065, China; Hubei Hospital of Traditional Chinese Medicine, Wuhan, 430061, China. E-mail:
lixiaodong555@126.com
Abstract
Objective
This study aimed to elucidate the mechanism of action of Paederia scandens in the treatment of nonalcoholic fatty liver disease (NAFLD).
Methods
The Tcmsp database was used as a search platform for main chemical components of Paederia scandens and screening for their target sites. NAFLD-related genes were obtained from the GeneCards and OMIM databases. Common target genes of the disease and drugs were mapped using the UniProt database, and the compound-target network of Paederia scandens and NAFLD was construct using the Cytoscape software. The string database was used to construct the protein interaction network to screen for core genes. Finally, the Gene Ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were carried out using the DAVID database to elucidate the possible mechanism of action of Paederia scandens.
Results
Based on the analyses, 57 target genes, seven common molecules, and four signaling pathways were found to be associated with the treatment of NAFLD with Paederia scandens. The data suggested that the mechanism of action of Paederia scandens might be related to insulin resistance and oxidative stress in the pathogenesis of NAFLD and might involve genes encoding important targets, such as AKT1, IL10, CYP1A2, CYP1A1, and CYP3A4.
Conclusion
Through network pharmacology, the mechanism of action of Paederia scandens in the treatment of NAFLD was elucidated, and the data provide new ideas for the use of Paederia scandens in the treatment of metabolic disorders.
Keywords
Paederia scandens,
NAFLD,
Network pharmacology
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Copyright © 2025 Authors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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About this Article
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Zhu H, Xiao MZ, Li XD. Network Pharmacology Analysis of the Mechanism of Action of Paederia scandens in the Treatment of NAFLD. Gastroenterol & Hepatol Res. 2019;1(1):25-31. doi: 10.53388/ghr2019-12-006.
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Article History
| Received |
Revised |
Accepted |
Published |
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December 12, 2019
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DOI
http://dx.doi.org/10.53388/ghr2019-12-006
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Gastroenterology & Hepatology Research
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eISSN 2703-173X