Correlations of Pathological Grade and HBV-DNA Level with Gallbladder Disease Occurrence in Patients with Chronic Hepatitis B
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Huan Chen1 and
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Xiu-Hui Li1,*
Author information
Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Correspondence to: Xiu-Hui Li, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China. E-mail:
lixiuhui@sohu.com.
Abstract
Objective
To investigate the correlations of pathological grade and HBV-DNA level with the occurrence of gallbladder diseases in patients with chronic hepatitis B, and to improve clinicians' understanding of this disease.
Methods
A total of 282 inpatients with chronic hepatitis B undergoing liver biopsy in Beijing Youan Hospital, Capital Medical University from January 2014 to April 2017 were enrolled. Data on liver pathological grade, HBsAg, HBeAg, HBV-DNA, and gallbladder disease conditions were retrospectively analyzed, and SPSS 19.0 software was used for statistical analysis.
Results
The incidence of gallbladder diseases in chronic hepatitis B patients were not significantly different among different HBsAg levels, between positive and negative HBeAg, or among different HBV-DNA groups (P>0.05). The higher the G grade and S stage of the liver pathology, the higher the incidence of gallbladder wall thickening, with a statistically significant difference (P<0.05).
Conclusion
Gallbladder wall thickening indicates that the degree of liver fibrosis in chronic hepatitis B patients is relatively high and can be used as one of the indexes to evaluate the progression of chronic hepatitis B.
Keywords
chronic hepatitis B,
pathological grading,
HBV-DNA level,
gallbladder diseases
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Copyright © 2025 Authors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Chen H, Li XH. Correlations of Pathological Grade and HBV-DNA Level with Gallbladder Disease Occurrence in Patients with Chronic Hepatitis B. Gastroenterol & Hepatol Res. 2020;2(3):75-80. doi: 10.53388/ghr2020-09-018.
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Article History
| Received |
Revised |
Accepted |
Published |
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September 12, 2020
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DOI
http://dx.doi.org/10.53388/ghr2020-09-018
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Gastroenterology & Hepatology Research
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eISSN 2703-173X