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Traditional Chinese herbal medicine plus triple therapy in treating Helicobacter pylori induced chronic atrophic gastritis: a meta-analysis and cumulative meta-analysis
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Kai Xiong1,
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Ting-hui Yue1,
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Tao Yang2,
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Wen-ting Hu1,
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Jia Deng1 and
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Tian-bao Xiao2,*
Author information
Guizhou University of Traditional Chinese Medicine, College of Clinical Medicine, Guiyang, 550002, China
The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China
Correspondence to: Tian-bao Xiao, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China. E-mail:
prof_xiaotianbao@163.com
Abstract
Objective
To evaluate the benefits of traditional Chinese herbal medicine (TCHM) plus triple therapy (TT) in the management of Helicobacter pylori (H. pylori)-induced chronic atrophic gastritis (CAG).
Methods
A comprehensive access and electronic database search were carried out from inception to June 2020. Prospective randomized trials (TCHM plus TT vs. TT) were selected to assess the eradication rate of H. pylori (ER of H. pylori), clinical symptom relief rate (SRR), treatment-related adverse reactions (TRAR) and 95% confidence intervals (CI) in the meta-analysis and cumulative meta-analysis (CMA). Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.
Results
33 studies contained 3,226 participants were included. Compared with the TT group, TCHM plus TT group showed a significantly higher ER of H. pylori (OR=4.14, 95% CI: 3.21-5.35; P=0.000) and SRR (OR=4.50, 95% CI: 3.59-5.64). Meanwhile, the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly (RR=0.43, 95% CI: 0.29-0.64; P=0.000). The results of the CMA, sorted by publication year, duration of treatment, and sample size, confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H. pylori and SRR.
Conclusions
The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H. pylori-induced CAG.
Keywords
Traditional Chinese herbal medicine,
Triple therapy,
Helicobacter pylori,
chronic atrophic gastritis,
Meta-analysis,
Cumulative meta-analysis
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Copyright © 2025 Authors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Xiong K, Yue TH, Yang T, Hu WT, Deng J, Xiao TB. Traditional Chinese herbal medicine plus triple therapy in treating Helicobacter pylori induced chronic atrophic gastritis: a meta-analysis and cumulative meta-analysis. Gastroenterol & Hepatol Res. 2022;4(1):6. doi: 10.53388/ghr2022-03-048.
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Article History
| Received |
Revised |
Accepted |
Published |
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March 30, 2022
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DOI
http://dx.doi.org/10.53388/ghr2022-03-048
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Gastroenterology & Hepatology Research
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eISSN 2703-173X