Non-alcoholic fatty liver disease (NAFLD) has become the world's most common chronic liver disease and is considered one of the main causes of occult liver cirrhosis. To date, major guidelines in China and abroad have not recommended any drugs with precise efficacy and safety for NAFLD, especially for NAFLD-related liver fibrosis or cirrhosis, which lack effective drugs. Traditional Chinese medicine has significant curative effects and advantages in preventing and treating NAFLD. We retrospectively analyzed a case of liver cirrhosis due to NAFLD that was treated solely with traditional Chinese medicine for nearly one year at the Diagnosis and Treatment Center of Advantage Specific Diseases for Fatty Liver in our hospital to provide a reference for the prevention and treatment of non-alcoholic liver fibrosis and liver cirrhosis by traditional Chinese medicine.