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Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining, network pharmacology and molecular docking technology
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Rui-Zhu Jiang1,
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Yu-Hong Ling1,
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Xin-Rui Xian1,
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Xian-Ling Yuan2,
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Yang Zheng1,
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Jia-Hui Wang1 and
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Tie-Jian Zhao2,*
Author information
Department of Medicine, Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Guangxi 530222, China
School of Basic Medical, Guangxi University of Chinese Medicine, Guangxi 530222, China
Correspondence to: Tie-Jian Zhao, School of Basic Medical, Guangxi University of Chinese Medicine, Guangxi 530222, China. E-mail:
570041687@qq.com.
Abstract
Objective
To study the mechanism of action of Xiayuxue Tang in treating hepatic fibrosis by combining GEO data mining, network pharmacology, and molecular docking technology, and provide new research directions for the treatment of hepatic fibrosis.
Method
Utilizing multiple databases, we aim to identify the relevant targets of various components in Xiayuxue Tang and their associations with hepatic fibrosis. After pinpointing the key targets through interaction analysis, we will construct both the compound-target network and the protein interaction network for Xiayuxue Tang. Conclusively, we will conduct GO and KEGG enrichment analyses on these key targets, followed by molecular docking verification.
Result
Through mining the GEO database, 171 related targets were identified. When combined with other databases, a total of 2,343 hepatic fibrosis-related targets were obtained. Xiayuxue Tang comprises 82 related components, which include 26 active components from rhubarb, 1 from ground beetle worm, 46 from peach kernels, with a total of 314 predicted targets. The GO enrichment analysis revealed 748 biological processes, 32 cellular components, and 73 molecular functions, while the KEGG enrichment analysis identified 222 pathways. Molecular docking verification confirmed that effective compounds can bind stably to key proteins, exhibiting strong binding activity. This underscores the potential efficacy of Xiayuxue Tang in addressing hepatic fibrosis.
Conclusion
Xiayuxue Tang exerts regulatory effects on hepatic fibrosis through different targets and pathways, suggesting that the herbal compound has the characteristics of multiple pathways and targets.
Keywords
Xiayuxue Tang,
hepatic fibrosis,
network pharmacology,
molecular docking technology
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Copyright © 2025 Authors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Jiang RZ, Ling YH, Xian XR, Yuan XL, Zheng Y, Wang JH, et al. Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining, network pharmacology and molecular docking technology. Gastroenterol & Hepatol Res. 2023;5(3):15-15. doi: 10.53388/ghr2023-03-079.
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Article History
| Received |
Revised |
Accepted |
Published |
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September 25, 2023
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DOI
http://dx.doi.org/10.53388/ghr2023-03-079
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Gastroenterology & Hepatology Research
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eISSN 2703-173X