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Shao Yao Decoction exerts a protective effect on ulcerative colitis by inhibiting inflammation mediated by hypercoagulability
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Huan-Tian Cui1,
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Yu-Ming Wang2 and
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Ning Wang1,*
Author information
The First Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming 650500, China
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Correspondence to: Ning Wang, The First Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming 650500, China. E-mail:
wnworkemail@163.com
Abstract
Background
Shaoyao decoction (SYD) has been found widespread clinical use in treating ulcerative colitis (UC). However, the mechanism underlying SYD impact on UC remains elusive.
Materials and methods
We preliminarily evaluated the therapeutic effect of SYD intervention in a dextran sulfate sodium-induced UC mouse model by analyzing the body weight change, disease activity index score, colon length, and HE staining results of colon tissue in each group of mice. Subsequently, we determined pro-inflammatory cytokines level and blood coagulation markers in the colon tissues of mice in each group to evaluate the effect of SYD intervention on colonic inflammatory response and coagulation function in UC mice.
Results
Our findings emphasize the significant therapeutic effect of SYD on UC, including slowed down body weight loss, reduced disease activity index score, increased colon length, and reduced inflammatory infiltration in colon tissue. Moreover, SYD intervention significantly downregulated the levels of pro-inflammatory cytokines IL-1β, IL-6, and IL-17A in the colon. Furthermore, SYD intervention reversed the coagulation-related indicators such as prothrombin time, fibrinogen, P-selectin, D-dimer, and platelet glycomembrane protein IIb/IIIa.
Conclusion
Our results elucidate the substantial therapeutic impact of SYD on UC mice. Importantly, the therapeutic mechanism of SYD in addressing UC potentially involves the inhibiting of inflammatory response mediated by hypercoagulability.
Keywords
Shaoyao decoction,
ulcerative colitis,
hypercoagulability,
inflammation,
traditional Chinese medicine
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Copyright © 2025 Authors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Cui HT, Wang YM, Wang N. Shao Yao Decoction exerts a protective effect on ulcerative colitis by inhibiting inflammation mediated by hypercoagulability. Gastroenterol & Hepatol Res. 2024;6(1):1. doi: 10.53388/ghr2024001.
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Article History
| Received |
Revised |
Accepted |
Published |
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March 29, 2024
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DOI
http://dx.doi.org/10.53388/ghr2024001
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Gastroenterology & Hepatology Research
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eISSN 2703-173X