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Clinical Evidence of Association Between Type-2 Diabetes Mellitus and Hypothyroidism with Therapeutic Relevance—An Observational Study

  • Surampalli Gurunath1,*,
  • Koyyada Arun2,
  • Amgoth Vamshi Krishna2,
  • Lekkala Kavya2 and
  • Bathula Sridhar3
 Author information
Journal of Exploratory Research in Pharmacology   2019;4(3):21-30

doi: 10.14218/JERP.2019.00001

Abstract

Background

Thyroid disorder and diabetes are associated endocrine disorders. Patients with either one of the disorders are at great risk of developing the other. The co-existence of type-2 diabetes mellitus (T2DM) and hypothyroidism with clinical evidence of effect on one another has not been reported until today.

Methods

This prospective study involved 702 patients. Each participant’s blood sugar levels and thyroid profiles were statistically analyzed using unpaired t-test.

Results

The incidence of hypothyroidism and hyperthyroidism in diabetic patients was 20.2% and 1.71% respectively, while the incidence of type-1 diabetes mellitus and T2DM in thyroid dysfunction patients was 0.56% and 19.03% respectively. The mean fasting blood sugars and postprandial blood sugar levels, triiodothyronine, thyroxine and Thyroid stimulating hormone levels of hypothyroid patients with T2DM (157.2 ± 4.779, 231.7 ± 6.291, 1.123 ± 0.065, 8.643 ± 1.519 and 12.22 ± 1.974) were not significantly different (p > 0.05) from those in T2DM patients with hypothyroidism (153.6 ± 7.181, 236.6 ± 9.504, 1.091 ± 0.013, 7.971 ± 1.024 and 12.09 ± 1.48). These findings were above the normal range (fasting blood sugar of 70–110 mg/dL; postprandial blood sugar of >140 mg/dL) thyroid stimulating hormone of 0.39–6.16 mIU/L in both type of patients, with the exception of triiodothyronine and thyroxine.

Conclusions

We report clinical evidence of association between hypothyroidism and diabetes mellitus with the highest incidence of hypothyroidism in T2DM with four major findings, suggesting regular thyroid and glycemic level evaluations for diabetic and hypothyroid patients respectively. Thus adjustment of dosage of levothyroxine is necessary, with prompt monitoring and reduction of the dose of insulin or oral hypoglycemic drugs to avoid hypoglycemia and its complications.

Keywords

Hypothyroidism, Hyperthyroidism, Type-1 DM, Type-2 DM, Endocrine disorders

Introduction

Diabetes and thyroid disorders are the most common endocrine disorders seen in the general population. These two disorders are mutually associated and influence each other. In hypothyroidism, the metabolism of glucose is affected by several mechanisms, such as perturbed genetic expression of genes with physiological aberrations leading to impaired glucose utilization and disposal in muscles, overproduction of hepatic glucose output, and enhanced absorption of splanchnic glucose,1 thereby predisposing to diabetes mellitus. It is well established that hyper- and hypothyroidisms are associated with insulin resistance and are reported to be the major cause of impaired glucose metabolism in type-2 diabetes mellitus (T2DM)1 and worsen glycemic control.2

Among thyroid disorders, hypothyroidism is most common worldwide. It is commonly found to co-exist with type-1 diabetes mellitus (T1DM) and T2DM. It is thought to be the precipitating factor for hypoglycemia in diabetic patients.3 In addition the incidence of hypothyroidism increases with age and is more common in women.4

The prevalence of T2DM (about 90%) is greater compared to that of T1DM (about 10%) among the diabetes mellitus population due to increase in sedentary lifestyle and obesity. Also, the incidence of hypothyroidism is higher in T2DM patients than in T1DM patients.1 It is well known that thyroid hormones are insulin antagonists. Insulin has been found to inhibit the conversion of thyroxine (T4) to triiodothyronine (T3); thus, showing hypothyroidism in diabetic patients with significantly lower serum levels of T3 and T4 than in diabetic subjects without hypothyroidism.5 Moreover diabetic hypothyroid patients who were on metformin showed baseline reduction of thyroid stimulating hormone (TSH) level after 6 months. This shows the relation of antidiabetic therapy and risk of hypothyroidism.1

It has been three decades up to today to report that diabetes mellitus influences the assessment of thyrotoxicosis by falsely decreasing the blood levels of T4 and T3 with severely uncontrolled hyperglycemia. Hypothyroidism seems to ameliorate hyperglycemia.6 In a review published recently, Hage, et al.,7 reported that diabetes mellitus and thyroid disorders tend to coexist in patients but none of the clinical studies have reported the diabetes mellitus and thyroid disorders interrelationship in a two-way fashion (particularly hypothyroidism↔T2DM). Our study has revealed, for the first time, the incidences of these disorders over prevalence with strong clinical evidence of association between hypothyroidism and T2DM and vice versa.

Methods

The study’s protocol was approved prior to the start of the study by the Human Institutional Ethics Committee and all participants and/or their parents or legally responsible persons provided informed consent. All procedures performed in our studies involving human participants were designed and carried out in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments, or comparable ethical standards.

This observational study was conducted in the North Telangana region. The study was conducted over a period of 6 months during 2017. The design was enabled to determine a) the incidence of T1DM and T2DM in patients with preexisting hypothyroidism and hyperthyroidism and b) the incidence of hypothyroidism and hyperthyroidism with pre-existing T1DM and T2DM. The diabetic patients enrolled were taking insulin and/or oral hypoglycemic agents and the hypothyroid patients were on levothyroxine (25/50/75/88/100/125 mcg) therapy. A suitable data collection form was designed to collect, document and analyze the data. All the relevant and necessary data pertaining to blood glucose and thyroid profiles were collected from patients’ laboratory reports. The total study population was 702 patients, of whom 350 patients had preexisting T1DM and T2DM and 352 patients had preexisting hypothyroidism and hyperthyroidism.

Based on the thyroid profile, hypothyroidism was considered when T3 and T4 levels were lesser and TSH levels were greater than the laboratory reference values. Hyperthyroidism was considered when T3 and T4 were greater and TSH levels were lesser than the laboratory reference values.

Inclusion criteria

Exclusion criteria

Statistical analysis

Data were analyzed using GraphPad Prism software, version 6.0. Quantitative data were expressed using mean and standard deviation while qualitative data were expressed in frequency and percent. Quantitative data were analyzed using nonparametric Kruskal-Wallis test to compare between the two groups. The p value was assumed to be significant at 0.05 or less.

Results

As stated above the total patients included in this study was 702. Among them, 350 patients presented with predisposing diabetes (T1DM and T2DM). Out of those 350 patients, 25 had with T1DM and 325 had T2DM. Table 1 shows the number and percentage of distribution of diabetic patients. Also out of the 350 patients, 77 (22%) presented with predisposing diabetes, affected with thyroid disorders (hypothyroidism and hyperthyroidism). The T2DM patients were more prone to be affected with thyroid dysfunction (with more hypothyroidism prevalence) than were the T1DM patients. The distribution of thyroid disorders in T1DM and T2DM is shown in Table 1. Based on our findings, we considered T2DM with and without hypothyroidism for statistical outcomes.

Table 1

Percentage distribution of diabetic and thyroid patients

Type 1 DM (N = 25)Type 2 DM (N = 325)Hypothyroidism (N = 305)Hyperthyroidism (N = 47)
Male16 (4.57 %)159 (45.42 %)29 (8.23 %)05 (1.4%)
Female09 (2.57 %)166 (47.42 %)276 (78.4 %)42 (11.9%)

Out of the 702 total patients, the remaining 352 presented with predisposing hypothyroidism (n = 305) and hyperthyroidism (n = 47) respectively. Hypothyroidism was found to be more affected in the general population than was hyperthyroidism. These patients were further screened for diabetes mellitus. Out of the 352 thyroid patients (both hypothyroidism and hyperthyroidism), 69 (19.6%) were affected with diabetes. However, it was noticed that the patients with predisposing hypothyroidism were more prone to diabetes (more T2DM prevalence) than those with hyperthyroidism. Table 2 shows the number of thyroid distribution among diabetic patients.

Table 2

Distribution of thyroid disorders in diabetic patients and diabetes in thyroid patients respectively

Patients with T1DM
Patients with T2DM
Hypothyroidism patients
Hyperthyroidism patients
Hypothyroidism (n = 3)Hyperthyroidism (n = 0)Hypothyroidism (n = 68)Hyperthyroidism (n = 6)Type-1 DM (n = 2)Type-2 DM (n = 65)Type-1 DM (n = 0)Type-2 DM (n = 2)
Male0000130000110000
Female0300550602540002

To our surprise, thyroid disorder patients were more prone to developing T2DM than T1DM. The incidence of thyroid disorders (hypothyroidism and hyperthyroidism) in diabetes patients was found to be 22.5%. The hypothyroidism incidence was significantly higher with 20.2% than the incidence of hyperthyroidism (1.71%). Our findings showed that the incidence of thyroid disorders in diabetic patients was higher in females (18.2%) than the males (3.71%).

Further, our study included 352 thyroid patients (hypothyroidism and hyperthyroidism), among which the incidence of diabetes in known thyroid disorder patients (n = 352) was 19.6%. Females with thyroid disorders were found to be 90.3% and among those incidences of getting diabetes was 15.9%. T2DM incidence was greater in the thyroid patients than for T1DM.

Comparison of fasting blood sugar (FBS), postprandial blood sugar (PLBS) and thyroid hormones in T2DM patients with and without hypothyroidism

It was found that the mean FBS (175.7 ± 5.164 mg/dL, 153.6 ± 7.181 mg/dL, p < 0.0385) and PLBS (261.4 ± 5.971 mg/dL, 236.6 ± 9.504 mg/dL, p < 0.0481) of the diabetic patients without hypothyroidism were significantly higher when compared with those diabetic patients with hypothyroidism (Table 3 and Fig. 1a). Our findings showed significantly lowered levels of glucose in diabetic patients with hypothyroidism, as compared to those diabetic patients without hypothyroidism as reported by several studies.2,3 These results indicate hypoglycemia in T2DM patients under the influence of hypothyroidism.

(a) Comparison of FBS and PLBS in T2DM patients with and without hypothyroidism using unpaired <italic>t</italic>-test; (b) Comparison of thyroid hormone profiles in T2DM patients with and without hypothyroidism using unpaired <italic>t</italic>-test.
Fig. 1  (a) Comparison of FBS and PLBS in T2DM patients with and without hypothyroidism using unpaired t-test; (b) Comparison of thyroid hormone profiles in T2DM patients with and without hypothyroidism using unpaired t-test.

FBS, fasting blood sugar; Hypothy, Hypothyrodism; PLBS, postprandial blood sugar; T2DM, type-2 diabetes mellitus. wt/o, without; wt, with; *means statistically significant at P < 0.05, #means statistically insignificant.

Table 3

Comparison of FBS, PLBS and thyroid hormones in T2DM patients with and without hypothyroidism using unpaired t-test

TestType-2 diabetics without hypothyroidism (n = 251)Type-2 diabetics with hypothyroidism (n = 68)p value
FBS (mg/dl)175.7 ± 5.164153.6 ± 7.1810.0385*
PLBS (mg/dl)261.4 ± 5.971236.6 ± 9.5040.0481*
TSH (mIU/ml)8.12 ± 1.7312.09 ± 1.480.01*
T3 (ng/dl)1.074 ± 0.0491.091 ± 0.0130.654#
T4 (µg/dl)5.072 ± 0.9197.971 ± 1.0240.0231*

The thyroid profile (T3, T4 and TSH) in the diabetic patients without hypothyroidism was compared with those diabetic patients with hypothyroidism. Table 3 and Figure 1b show the comparison between the two groups containing T2DM with and without hypothyroidism. The statistical analysis using unpaired t-test showed that the T4, TSH but not T3 levels varied significantly (p < 0.05) between the groups. The mean T4 (5.072 ± 0.919 µg/dL, p < 0.0231) and TSH (8.12 ± 1.73 mIU/mL, p < 0.01) of T2DM without hypothyroidism were significantly less compared to those of T2DM with hypothyroidism (7.971 ± 1.024 µg/dL, 12.09 ± 1.48 mIU/mL). The mean values of T3 (1.074 ± 0.049 ng/dL) of T2DM without hypothyroidism were not significant as compared to those of T2DM patients with hypothyroidism (1.091 ± 0.013 ng/dL, p > 0.654). These findings indicate that T2DM influences the thyroid profiles in hypothyroid patients with increasing levels of T4 and TSH, because the patients were on treatment with metformin/insulin. The raised insulin levels inhibit conversion of T4 to T3.

Comparison of FBS, PLBS and thyroid hormones in hypothyroid patients with and without T2DM

It was found that the mean FBS (157.2 ± 4.779 mg/dL, 85.7 ± 2.31 mg/dL, p < 0.0014) and PLBS (231.7 ± 6.291 mg/dL, 123.7 ± 4.5 mg/dL, p < 0.0018) of the hypothyroid patients with T2DM were significantly higher when compared with those hypothyroid patients without T2DM (Table 4 and Fig. 2a). These findings demonstrated that hypothyroidism in T2DM patients causes hyperglycemia with increased levels of FBS and PLBS. This is because the patients were on levothyroxine therapy, for which the increased thyroid hormones induces hepatic gluconeogenesis and increased absorption of glucose leading to increased sugar levels.

(a) Comparison of FBS and PLBS in hypothyroid patients with and without T2DM using unpaired <italic>t</italic>-test; (b) Comparison of thyroid hormone profiles in hypothyroid patients with and without T2DM using unpaired <italic>t</italic>-test.
Fig. 2  (a) Comparison of FBS and PLBS in hypothyroid patients with and without T2DM using unpaired t-test; (b) Comparison of thyroid hormone profiles in hypothyroid patients with and without T2DM using unpaired t-test.

FBS, fasting blood sugar; Hypothy, Hypothyrodism; PLBS, postprandial blood sugar; T2DM, type-2 diabetes mellitus. wt/o, without; wt, with; *means statistically significant at P < 0.05, #means statistically insignificant.

Table 4

Comparison of FBS, PLBS and thyroid hormones in hypothyroid patients with and without T2DM using unpaired t-test

TestHypothyroidism without Type-2 DM (n = 236)Hypothyroidism with Type-2 DM (n = 65)p value
FBS (mg/dl)85.7 ± 2.31157.2 ± 4.7790.0014*
PLBS (mg/dl)123.7 ± 4.5231.7 ± 6.2910.0018*
TSH (mIU/ml)27.95 ± 2.57412.22 ± 1.9740.0016**
T3 (ng/dl)1.321 ± 0.0741.123 ± 0.0650.0538#
T4 (µg/dl)6.675 ± 0.2088.643 ± 1.5190.0287*

The thyroid profile (T3, T4 and TSH) in hypothyroid patients without diabetes was compared with predisposing thyroid patients with T2DM. Table 4 and Figure 2b show the comparison between the two groups containing hypothyroid patients with and without T2DM. The statistical analysis using unpaired t-test showed that the T4 and TSH but not T3 levels varied significantly (p < 0.05) between the groups. The mean TSH levels (12.22 ± 1.974 mIU/mL, p < 0.0016) of thyroid patients without diabetes were found to be significantly less than those for the hypothyroid patients with diabetes (27.95 ± 2.574 mIU/mL) whereas T4 (8.643 ± 1.519 µg/dL, p < 0.0287) of hypothyroid patients without diabetes were significantly more compared to that of predisposing hypothyroid patients having diabetes (6.675 ± 0.208 µg/dL). The mean values of T3 (1.321 ± 0.074 ng/dL, 1.123 ± 0.065 ng/dL) of thyroid patients with diabetes were not significantly different (p < 0.5389) from those of the group of thyroid patients without diabetes. These results demonstrate that hypothyroidism in T2DM patients is related to decreased levels of TSH when compared to hypothyroid patients without diabetes. However, T4 levels were raised in the hypothyroid patients with T2DM, without any changes in the levels of T3.

Comparison of FBS, PLBS and thyroid hormones in T2DM patients without hypothyroidism and hypothyroid patients without T2DM

It was found that the mean FBS (175.7 ± 5.164 mg/dL, 85.7 ± 2.31 mg/dL, p < 0.01) and PLBS (261.4 ± 5.971 mg/dL, 123.7 ± 4.5 mg/dL, p < 0.01) of the hypothyroid patients without T2DM was significantly less when compared with those of the T2DM patients without hypothyroidism (Table 5 and Fig. 3a). These findings illustrated that hypothyroidism influences FBS and PLBS levels in the absence of T2DM.

(a) Comparison of FBS and PLBS in T2DM patients without hypothyroidism and hypothyroid patients without T2DM using unpaired <italic>t</italic>-test; (b) Comparison of thyroid hormone profiles in T2DM patients without hypothyroidism and hypothyroid patients without T2DM using unpaired <italic>t</italic>-test.
Fig. 3  (a) Comparison of FBS and PLBS in T2DM patients without hypothyroidism and hypothyroid patients without T2DM using unpaired t-test; (b) Comparison of thyroid hormone profiles in T2DM patients without hypothyroidism and hypothyroid patients without T2DM using unpaired t-test.

FBS, fasting blood sugar; Hypothy, Hypothyrodism; PLBS, postprandial blood sugar; TSH, Thyroid stimulating hormone; T2DM, type-2 diabetes mellitus; T3, triiodothyronine; T4, thyroxine. wt/o, without; wt, with; *means statistically significant at P < 0.05, #means statistically insignificant.

Table 5

Comparison of FBS, PLBS and thyroid hormones in T2DM patients without hypothyroidism and hypothyroid patients without T2DM using unpaired t-test

TestType-2 diabetics without hypothyroidism (n = 251)Hypothyroidism without Type-2 DM (n = 236)p value
FBS (mg/dl)175.7 ± 5.16485.7 ± 2.310.01*
PLBS (mg/dl)261.4 ± 5.971123.7 ± 4.50.01*
TSH (mIU/ml)8.12 ± 1.7327.95 ± 2.5740.0034**
Total T3 (ng/dl)1.074 ± 0.0491.321 ± 0.0740.571#
Total T4 (µg/dl)5.072 ± 0.9196.675 ± 0.2080.432#

Comparison of FBS, PLBS and thyroid hormones in T2DM patients with hypothyroidism and hypothyroid patients with T2DM using unpaired t-test

It was found that the mean FBS (157.2 ± 4.779 mg/dL, 153.6 ± 7.181 mg/dL, p > 0.05) and PLBS (231.7 ± 6.291 mg/dL, 236.6 ± 9.504 mg/dL, p > 0.05) of the hypothyroid patients with T2DM were not significantly different when compared to those of T2DM patients with hypothyroidism (Table 6 and Fig. 4a). These findings indicated that either T2DM or hypothyroidism were equally effective on each other with reference to glycemic levels.

(a) Comparison of FBS and PLBS in T2DM patients with hypothyroidism and hypothyroid patients with T2DM using unpaired <italic>t</italic>-test; (b) Comparison of thyroid hormones profiles in T2DM patients with hypothyroidism and hypothyroid patients with T2DM using unpaired <italic>t</italic>-test.
Fig. 4  (a) Comparison of FBS and PLBS in T2DM patients with hypothyroidism and hypothyroid patients with T2DM using unpaired t-test; (b) Comparison of thyroid hormones profiles in T2DM patients with hypothyroidism and hypothyroid patients with T2DM using unpaired t-test.

FBS, fasting blood sugar; PLBS, postprandial blood sugar; TSH, Thyroid stimulating hormone; T2DM, type-2 diabetes mellitus. T3, triiodothyronine; T4, thyroxine. wt/o, without; wt, with; #means statistically insignificant at P > 0.05.

Table 6

Comparison of FBS, PLBS and thyroid hormones in T2DM patients with hypothyroidism and hypothyroid patients with T2DM using unpaired t-test

TestType-2 diabetics with hypothyroidism (n = 68)Hypothyroidism with Type-2 DM (n = 65)p value
FBS153.6 ± 7.181157.2 ± 4.7790.347#
PLBS236.6 ± 9.504231.7 ± 6.2910.231#
TSH12.09 ± 1.4812.22 ± 1.9740.675#
T31.091 ± 0.0131.123 ± 0.0650.758#
T47.971 ± 1.0248.643 ± 1.5190.579#

The thyroid profile (T3, T4 and TSH) in T2DM with hypothyroidism was compared with that of predisposing hypothyroid patients with T2DM. Table 6 and Figure 4b shows the comparison between the two groups containing T2DM patients with hypothyroidism and hypothyroid patients with T2DM. The statistical analysis using unpaired t-test showed that the T4, TSH and T3 levels were not varied significantly (p > 0.05) between the groups. The mean values of T3 (1.091 ± 0.013 ng/dL, 1.123 ± 0.065 ng/dL, p > 0.075); T4 (7.971 ± 1.024 µg/dL, 8.643 ± 1.519 µg/dL, p > 0.057) and TSH (12.09 ± 1.48 mIU/mL, 12.22 ± 1.974 mIU/mL, p > 0.067) of T2DM patients with hypothyroidism were not significantly different when compared to those of hypothyroid patients with T2DM. These findings showed that either T2DM or hypothyroidism were equally influencing on one another with respect to thyroid profile.

Discussion

This study was done with the purpose of evaluating the incidence of thyroid disorders (hypothyroidism and hyperthyroidism) in diabetes mellitus and vice versa to evaluate their effects on one another. Our study provided impressive results with significant correlation between hypothyroidism and T2DM and vice versa. Several clinical studies in endocrinology showed the relationship between thyroid disorders and diabetes mellitus, but none have shown their interrelationship in a two-way fashion (hypothyroidism↔T2DM). Our study revealed the first of its kind in reporting novel clinical evidence of incidence and the interrelationship between hypothyroidism and T2DM and vice versa. In diabetic patients the incidence of hypothyroidism was found to be greater compared to the patients with hyperthyroidism, whereas in thyroid dysfunction patients incidence of T2DM is greater compared to the patients with T1DM. Therefore, hypothyroidism in T2DM and T2DM in hypothyroidism were taken into consideration for this study.

This is a unique clinical study as a clinical evidence to be new of its kinds showing an association between T2DM and hypothyroidism and vice versa, since no such reports are available until today.

The mean FBS and PLBS levels of T2DM patients without hypothyroidism was significantly higher than those of the T2DM patients with hypothyroidism. It is well-known, that hypoglycemia occurs in a greater amount of diabetic hypothyroid patients than in diabetic patients without hypothyroidism. The significant factors that contribute to hypoglycemia are reduced insulin clearance, slow gastric emptying and decreased intestinal absorption of glucose. Further, biochemical effects like reduced gluconeogenesis, impaired glycogenolysis and reduced glucagon secretion prevent recovery from hypoglycaemia.8,9 Additionally, the hepatic glucose output is decreased followed by prolonged insulin half-life. Therefore, the doses of exogenous insulin may have to be decreased to avoid hypoglycaemia.10–12 On the other hand, hypothyroid patients with T2DM show significantly increased T4 and decreased T3 and TSH levels when compared to hypothyroid patients without T2DM; this agrees with the previously reported observations of insulin enhancing the levels of T4 while suppressing the levels of T3 by inhibiting hepatic conversion of T4 to T3.13 On the other hand, diabetic hypothyroid patients showed increased T4 and TSH levels when compared with diabetic patients without hypothyroidism. These findings agree with another study, in which raised serum TSH levels were observed in T2DM patients suffering from hypothyroidism.8 The main findings of our study are that our diabetic patients were more prone to thyroid disorders than were our thyroid patients to getting diabetes, with female patients being more at risk.

Upon comparing the mean FBS and PLBS levels of T2DM without hypothyroidism and hypothyroidism without T2DM, we found hypoglycemia in hypothyroid patients without T2DM. Hypothyroidism is linked with various hormonal, biochemical and nervous system abnormalities which may contribute to hypoglycemia. Hypothyroid patients have relative adrenal insufficiency, even if the patients do not have primary adrenal failure. There is a blunted hypothalamo-pituitary-adrenal response to hypoglycemia in hypothyroid patients.14,15 However, significant changes in the thyroid profile in terms of TSH levels were noticed in our hypothyroid patients without T2DM than the T2DM patients without hypothyroidism. Agreeing with findings from other studies, T2DM showed prominent effect on thyroid hormones with the prevalence of thyroid disorders in patients of T2DM.7,8,10,11,16–18

A cross-sectional study reported high incidence of thyroid dysfunction (28%) in T2DM patients, with subclinical hypothyroidism (18.8%) as the most common thyroid disorder.19 In addition, Ravishankar et al.,20 reported the prevalence of thyroid disorders in T2DM as 29%,20 in agreement with the results of Unnikrishnan and colleagues (overall prevalence of hypothyroidism begin 10.95% (n = 587) of which 3.47% were previously undetected and 7.48% were self-reported cases).21 Further, Prasad et al,22 reported the 23% prevalence of hypothyroidism and 10% of hyperthyroidism with marked increase in level of TSH among diabetic patients with hypothyroidism with significant change in level of T3, T4 and TSH among cases and controls.22 The published results from Rai et al.,23 further supported our findings with decreased serum T3 and T4 and increased TSH levels in T2 diabetics without any complications.24,25

Further support for our findings is found among the recent studies that have shown that diabetic patients with nephropathy may be complicated by primary hypothyroidism. But, our study did not include T2DM patients with complications, which underlies the limitations of our findings for suggesting only minor changes in thyroid profiles in T2DM patients. Therefore further studies should be planned to evaluate the diabetic population regarding hypothyroidism as to whether it is clinical or sub-clinical.

Upon comparison of the mean FBS and PLBS levels of disorders (T2DM with hypothyroidism and hypothyroidism with T2DM), no significant changes in glycemic levels were noticed in hypothyroid diabetic patients when compared to diabetic hypothyroid patients. But, it was observed that FBS, PLBS and TSH levels were above the normal range in both the groups of patients and TSH, except T3 and T4. These findings indicate that either of the disorders is equally dominant on one another when normal ranges of glycemic and thyroid levels are taken into consideration. Therefore neither T2DM with hypothyroidism nor hypothyroidism with T2DM was found to be significant; hence, both of them are to be controlled and monitored strictly as co-existence of each other significantly influencing one another and relating to the normal values of glycemic and thyroid levels. Our findings stand out to be novel for endocrinologists and other researchers with prominent clinical evidence showing the association between T2DM and hypothyroidism and vice versa.

Our study findings signify clinical evidence of association between T2DM and hypothyroidism. The incidence of hypothyroidism was decreasing the levels of blood glucose in pre-existing diabetic patients, so that the dose of insulin or oral hypoglycemic drugs should be reduced to avoid hypoglycemia and its complications. On the other hand, it was observed that pre-existing hypothyroidism in diabetic patients, led to decreased T3 and TSH levels thus necessitating the adjustment of dosage of levothyroxine with prompt monitoring.

Conclusions

Our study showed that a significant interrelationship co-exists between hypothyroidism and diabetes mellitus. T2DM patients were more prone to be affected with thyroid dysfunction (hypothyroidism) than T1DM patients. The incidence of thyroid disorder in diabetes patients was significantly higher than the incidence of diabetes in thyroid disorder patients. On the other hand the patients with predisposing hypothyroidism were more prone to diabetes (T2DM) than those with hyperthyroidism. Hence, our study concluded four major findings:

Therefore, it is advisable to perform the regular thyroid evaluation for those patients who are diabetic and vice versa to avoid the complications and poor management of either. By early diagnosis and therapeutic intervention, one can improve the health status of the patient. Furthermore, related studies must be conducted in the near future to gain a better understanding of the underlying mechanisms for the observed association described herein.

Future research directions, prospectives, and predictions

Further clinical studies are under way, for the study of various risk factors and their mechanisms influencing the association of T2DM and hypothyroidism, and vice-versa.

Abbreviations

FBS: 

fasting blood sugar

PLBS: 

postprandial blood sugar

T1DM: 

type-1 diabetes mellitus

T2DM: 

type-2 diabetes mellitus

T3: 

triiodothyronine

T4: 

thyroxine

TSH: 

thyroid stimulating hormone

Declarations

Acknowledgement

The authors express their thanks to Dr. Anjani Devi, Chairperson, Kalyani Maternity Hospital, Hanamkonda and to Prof.Y. Madhusudhan Rao, Director, Vaagdevi Group of Pharmacy Colleges for their timely support in accomplishment of this clinical study. The study received no funding or grants and was carried out without any financial support.

Conflict of interest

The authors have no conflict of interests related to this publication.

Authors’ contributions

Manuscript writing (KA, AVK), figures and tables preparing (LK), review of the manuscript and its critical appraisal against the research objectives and its protocol (BS, SG).

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  • Journal of Exploratory Research in Pharmacology
  • pISSN 2993-5121
  • eISSN 2572-5505
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Clinical Evidence of Association Between Type-2 Diabetes Mellitus and Hypothyroidism with Therapeutic Relevance—An Observational Study

Surampalli Gurunath, Koyyada Arun, Amgoth Vamshi Krishna, Lekkala Kavya, Bathula Sridhar
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