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Network pharmacology-based analysis of the mechanism of Radix Paeoniae Alba against Toosendan Fructus-induced hepatotoxicity
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Heng Xu1,
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Yaqi Zhang2,
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Huan Chen2 and
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Tengfei Bai2
Author information
School of Life Sciences, Beijing University of Traditional Chinese Medicine, Beijing, China, 100029
College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, China, 071000
Correspondence to: No correspondence email available.
Abstract
Objective
To analyze and explore the key targets and molecular mechanisms of action of Radix Paeoniae Alba against Toosendan Fructus-induced hepatotoxicity and the relationship between corresponding compounds based on network pharmacology.
Methods
Using network pharmacology, a "traditional Chinese medicineâchemical compositionâkey targetâpathway" analysis was conducted on Radix Paeoniae Alba for the treatment of Toosendan Fructus-induced hepatotoxicity. The possible mechanism of action was analyzed in terms of function.
Results
The core targets, such as interleukin (IL)-6, tumor necrosis factor (TNF), heat shock protein 90 alpha family class A member 1 (HSP90AA1), peroxisome proliferator-activated receptor gamma (PPARG), prostaglandin-endoperoxide synthase 2 (PTGS2), heme oxygenase 1 (HMOX1), Jun proto-oncogene (JUN), caspase-3, estrogen receptor 1 (ESR1), and aryl hydrocarbon receptor (AHR) were screened from the targets of Radix Paeoniae Alba against Toosendan Fructus-induced hepatotoxicity. Biological process (BP) of toxic targets (BP terms) involved "response to drug; activation of cysteine-type endopeptidase activity involved in apoptotic process," positive regulation of transcription. Cellular components (CC terms) mainly involved cytosol and membrane rafts. Molecular function (MF) terms included "protein homodimerization activity," RNA polymerase II transcription factor activity and enzyme binding, etc." The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway included the TNF signaling pathway, cancer pathways, and apoptosis.
Conclusion
Radix Paeoniae Alba might alleviate Toosendan Fructus-induced hepatotoxicity through IL6, TNF, HSP90AA1, PPARG, PTGS2, HMOX1, and other targets, possibly via the activation of cysteine-type endopeptidase activity involved in these pathways.
Keywords
Radix Paeoniae Alba,
Toosendan Fructus,
liver toxicity,
network pharmacology,
compatibility
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Copyright © 2025 Authors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Xu H, Zhang Y, Chen H, Bai T. Network pharmacology-based analysis of the mechanism of Radix Paeoniae Alba against Toosendan Fructus-induced hepatotoxicity. Gastroenterol & Hepatol Res. 2022;4(1):3. doi: 10.53388/ghr2022-03-045.
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Article History
| Received |
Revised |
Accepted |
Published |
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March 30, 2022
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DOI
http://dx.doi.org/10.53388/ghr2022-03-045
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Gastroenterology & Hepatology Research
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eISSN 2703-173X