From ancient times to the present, the plague has had a huge impact on human life. Traditional Chinese medicine has also accumulated valuable epidemic prevention theories and methods from the practice of anti-epidemic, and formed a unique epidemic prevention thinking. Chinese medicine is good at using the thinking of the three talents of heaven, earth and human beings to adjust the epidemic situation according to the time and place, and uses the thinking of five transports and six qi to predict the development trend of the epidemic and guide the clinical treatment rules. Physicians of later generations summed up the characteristics of epidemics and put forward many theories and ideas of traditional Chinese medicine for epidemic prevention, including Wu Youxing's theory of suffocating qi and the thinking of dialectical treatment of Jiu Chuan, the differentiation and treatment method of Wei qi and nourishing blood of rotten throat Dansha, and the essence of grasping the essence of Lingnan famous Chinese medicine. Deng Tietao's thoughts on the diagnosis and treatment of SARS in the fight against SARS, etc. This article will summarize the thinking theories of traditional Chinese medicine for epidemic prevention and control and China's traditional epidemic prevention measures, and give an overview and explanation in combination with the current domestic new coronavirus prevention and control work.