The incidence of metabolic-associated fatty liver disease (MAFLD) is the highest among chronic liver disease worldwide, accounting for one-fourth to one-third of the world population and seriously affecting people's health. MAFLD is a multi-systemic disease, which is closely related to the occurrence and prognosis of many diseases. With an increase in research, studies have shown that MAFLD is associated with hepatitis virus infection, and this interaction affects the prognosis of the disease. This paper thus reviews the recent research progress in this field