Non-alcoholic fatty liver disease and type 2 diabetes are common comorbidities or target organ damage, which can lead to adverse metabolism and increased risk of cardiovascular and cerebrovascular diseases. In the management plan of non-alcoholic fatty liver disease and type 2 diabetes, there is no drug with significant efficacy or both. The dialectical idea of traditional Chinese medicine has a good curative effect and significant advantages in treating metabolic disorders. The author now reviewed a case of non-alcoholic steatohepatitis combined with type 2 diabetes. In this case, the method of invigorating the spleen and eliminating turbidity was effective, which effectively prevented the progression of liver disease in the patient, and T2DM was alleviated by maintaining within the standard range after the use of insulin was stopped. It can be said that "killing two birds with one stone", more fully reflects the advantages of traditional Chinese medicine in the integrated treatment of metabolic-related diseases.