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Online First Articles

The online first articles are peer reviewed, accepted, and are ready for publication, with copyediting, typesetting, proofreading and author review. They have not been assigned to a journal issue; an article will be removed from this page once it is published in a coming issue.

Articles published online first are citable. To cite an article on this page, please refer to the following example:

Yi SG, Sadhu AR, Jones SL, Turner K, Monsour H, Donahue K, et al. The Effect of Adrenal Replacement Therapy on Rates of Fungal Colonization and Mortality in Critically Ill Patients Awaiting Liver Transplantation. J Clin Transl Hepatol. Published online: Sep 15, 2013. doi: 10.14218/JCTH.2013.00007.

Guideline

Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care (2025)

Wenjing Ni, Junping Shi, Jian-Gao Fan, Jie Li, Chronic Disease Management Branch of China Medical Biotechnology Association, Chinese Research Hospital Society (Integrative Chinese and Western Medicine), Chinese Society of General Practice, Chinese Medical Association, and Expert Group of Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care

Published online: April 2, 2026

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doi:10.14218/JCTH.2025.00711

Original Article

Hepatic and Biliary Neoplasia

A Multi-omics Investigation Identifies TACC3 as a Driver of Immunosuppression in Intrahepatic Cholangiocarcinoma via Activation of the STAT3-PD-L1 Axis

Hao Wang, Zhiquan Xu, Ziqi Zhang, Yan You, Ranning Xu, Hongli Chen, Hongshuai Cui, Xiaoyong Luo, Rui Liao

Published online: April 10, 2026

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doi:10.14218/JCTH.2025.00616

Neu5Gc-associated Serum Immunoglobulin G Glycosylation as a Diagnostic Biomarker for Hepatocellular Carcinoma

Xu Cao, Xiwei Lu, Qingwei Li, Jiali Lu, Xiaoping Song, Yinglun Han, Chunwen Pu, Yue Pang

Published online: March 20, 2026

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doi:10.14218/JCTH.2025.00654

Liver Failure, Cirrhosis and Portal Hypertension

Single-cell Sequencing Reveals Neutrophil Extracellular Traps in Association with Endotheliopathy and Immunothrombosis in Hepatitis B Virus-related Acute-on-chronic Liver Failure

Xitang Li, Suping Hai, Xizhe Zheng, Peng Hu, Wenhui Wu, Qiang Gao, Junjian Hu, Binghui Yu, Feiyang Xu, Huiling Xiang, Qin Ning, Xiaojing Wang

Published online: April 10, 2026

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doi:10.14218/JCTH.2025.00666

Metabolic Liver Diseases

Tongue Image Analysis and Clinical Data Fusion: A Novel Approach for Non-invasive Diagnosis of Metabolic Dysfunction-associated Fatty Liver Disease

Chen-Xia Lu, Chuan-Xi Tian, Yi-Bo Jiao, Hui Zhu, Hai-Yan Yu, Zi-Xin Shu, Ling-Han Zhang, Jia Zhang, Lan Wang, Qi Hao, Wen-Bin Zou, Ming-Zhong Xiao, Cheng-Hai Liu, Qiu-Yang He, Bee Luan Khoo, Xiao-Dong Li

Published online: April 8, 2026

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doi:10.14218/JCTH.2025.00631

m1A Epitranscriptomic Control of NUPR1 by YTHDF1 Exacerbates Metabolic Dysregulation in Nonalcoholic Fatty Liver Disease

Nan Luo, Zhihai Xu, Dongmei Zhao, Xue Yang, Yu Tian, Rongkuan Li

Published online: April 2, 2026

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doi:10.14218/JCTH.2025.00570

Infectious Hepatitis

Pegylated Interferon-based Treatment Improves Response Rates in Immune-tolerant Patients with Chronic Hepatitis B: A Prospective Trial

Min Liu, Lili Zuo, Yuting Zhang, Bing Bu, An Xiao, Ling Zhu, Xiuying Ma, Yilan Wang, Wei Yue, Jiawei Geng, Xueshan Xia

Published online: March 31, 2026

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doi:10.14218/JCTH.2025.00712

Liver Transplantation and Surgery

Galectin-3 Promotes Graft Injury via NLRP3 Pyroptosis in Steatotic Liver Transplantation: A Therapeutic Target for Donor Optimization

Xianwu Yang, Shirui Huang, Ruisi Ma, Zhihui Zhu, Yingquan Zhuo, Jiafei Yang, Jun Du, Huajian Gu

Published online: March 24, 2026

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doi:10.14218/JCTH.2025.00561

Liver Injury, Autoimmune, and Cholestatic Diseases

A Multi-omics and Machine Learning Framework Identifies Plasma SBDS as a Causal Biomarker and Therapeutic Target in Primary Sclerosing Cholangitis

Pengfei Cheng, Yuanming Qiang, Yibo Sun, Binwei Duan, Yabo Ouyang, Guangming Li

Published online: March 20, 2026

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doi:10.14218/JCTH.2025.00676

Review Article

Dubin-Johnson and Rotor Syndromes: A Review and Update of Pathophysiological Mechanisms

Bianca Thakkar, George Y. Wu

Published online: April 9, 2026

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doi:10.14218/JCTH.2025.00560

Unlocking the Future of Hepatocellular Carcinoma Early Diagnosis: The Promise of Extracellular Vesicle Biomarkers

Kunxiang Li, Zhihua Zuo, Xinyi Ou, Miyuan Yang, Yirui Qin, Bing Zhang, Yongcan Guo

Published online: April 8, 2026

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doi:10.14218/JCTH.2025.00589

Mechanisms and Prognostic Assessment Value of Thyroid Hormone in Liver Failure

Hong Zhou, Hong Wu, Shao-Hui Su, Shan-Hong Tang

Published online: March 18, 2026

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doi:10.14218/JCTH.2025.00657

Congenital Portosystemic Shunts – A Review

George Y. Wu

Published online: February 4, 2026

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doi:10.14218/JCTH.2025.00090

Research Letter

Analysis of Protein Binding to Liver Mitochondria by Horizontal Polyacrylamide Gel Electrophoresis Using a Converted Agarose Electrophoresis Unit

Bianca Thakkar, George Y. Wu

Published online: February 27, 2026

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doi:10.14218/JCTH.2025.00651