Hepatic cirrhosis complicated by hypocalcemia is a common electrolyte disorder and a sign of severe disease. This article summarized the pathophysiological research progress of cirrhosis: systemic vasodilation, water balance and effect of antidiuretic hormone, non-osmotic stimulation of the renin-angiotensin-aldosterone system, sympathetic nervous system. At the same time, we discussed the mechanism and clinical symptoms of hyponatremia complicated with hepatorenal syndrome and hepatic encephalopathy. Finally, we summarized the treatment progress of cirrhosis complicated with hypocalcemia from the aspects of water restriction, hypertonic Saline, correction of hypokalemia, albumin infusion, drug therapies. In this way, we hope to provide a reference for the diagnosis and treatment of liver cirrhosis complicated by hypocalcemia.