Study on the potential mechanism of Pien Tze Huang Capsules against coronavirus disease 2019 based on network pharmacology
-
Hui Zhu1 and
-
Ming-Zhong Xiao1,2,*
Author information
Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei, China
The Affiliated Hospital of Hubei University of Chinese Medicine, Hubei, China
Correspondence to: Ming-Zhong Xiao, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei, China; The Affiliated Hospital of Hubei University of Chinese Medicine, Hubei, China. E-mail:
309452513@qq.com
Abstract
Objective
To discuss the possible underlying mechanism of the effect of Pien Tze Huang capsules (PTHCs) against coronavirus disease 2019 (COVID-19) using network pharmacology research methods.
Methods
Through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), in this study, we searched for the active ingredients of PTHC, including Sanqi (Panax notoginseng), Shedan (snake's bile), Niu-huang (Calculus Bovis or ox bezoars), and musk, as well as information on the corresponding targets. The GeneCards database was used to obtain relevant information on COVID-19 targets. The search tool for the retrieval of interacting genes/proteins (STRING) database was used to draw the protein−protein interaction network, and the R Programming Language was used to carry out gene ontology functional enrichment analysis and the Kyoto encyclopedia of genes and genomes pathway enrichment analysis.
Results
In PTHC, there were 12 compounds that met the conditions and 232 gene targets. Along with the 394 gene targets associated with COVID-19, there were 41 potential targets related to the PTHC ingredients against COVID-19. The key targets included RELA, interleukin (IL)-6, IL-1β, mitogen-activated protein kinase (MAPK) 1, and C-X-C motif chemokine ligand 8, whereas the potential signaling pathways were nuclear factor-κB, cytokine-cytokine receptor interaction, the hypoxia-inducible factor 1 signaling pathway, the chemokine signaling pathway, and the MAPK signaling pathway.
Conclusion
PTHCs have the potential to combat COVID-19 by modulating key targets and potential signaling pathways that regulate immune function, providing theoretical support for more TCM treatments against COVID-19.
Keywords
Pien Tze Huang Capsule,
COVID-19,
Network pharmacology
|
Copyright © 2025 Authors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
|
About this Article
Cite this article
|
Zhu H, Xiao MZ. Study on the potential mechanism of Pien Tze Huang Capsules against coronavirus disease 2019 based on network pharmacology. Gastroenterol & Hepatol Res. 2020;2(2):48-52. doi: 10.53388/ghr2020-06-013.
|
| Copied to clipboard
|
Copy
Export to RIS
Export to EndNote
|
|
Citation copied!
|
Article History
| Received |
Revised |
Accepted |
Published |
|
|
|
|
June 13, 2020
|
DOI
http://dx.doi.org/10.53388/ghr2020-06-013
-
Gastroenterology & Hepatology Research
-
-
eISSN 2703-173X