Impact of patatin-like phospholipase domain-containing-3 rs738409 polymorphism in chronic liver disease: a meta-analysis of 27,365 subjects
-
Yang Zheng1,
-
Lei Wang1,
-
Jia-Hui Wang1,
-
Tian-Jian Liang1,* and
-
Tie-Jian Zhao2,*
Author information
Department of Medicine, Faculty of Chinese Medicine science Guangxi University of Chinese Medicine, Nanning, Guangxi 530021, P. R. China
Department of Physiology, College of basic Medicine, Guangxi University of Chinese Medicine, Nanning, Guangxi 530021, P. R. China
Correspondence to: Tian-Jian Liang, Department of Medicine, Faculty of Chinese Medicine science Guangxi University of Chinese Medicine, Nanning, Guangxi 530021, P. R. China. E-mail:
zycc5@sina.com; Tie-Jian Zhao, Department of Physiology, College of basic Medicine, Guangxi University of Chinese Medicine, Nanning, Guangxi 530021, P. R. China. E-mail:
13014989836@163.com.
Abstract
Background
Some genetic association studies have investigated the potential role of patatin-like phospholipase domain-containing-3 (PNPLA3) polymorphisms in chronic liver disease, retrieving inconsistent results. Therefore, we performed a meta-analysis to further explore PNPLA3 rs738409 in a large pooled population with chronic liver disease.
Methods
Eligible studies were selected from PubMed, Embase, and CNKI databases. Studies heterogeneity was assessed using I2 statistics: when I2 >50% the random effects model was used to pool the data; otherwise, a fixed effects model was used.
Results
In total, 36 studies were selected, comprising 14,855 cases and 12,510 controls. The analysis showed that rs738409 was significantly associated with chronic liver disease in the general population (dominant model: P < 0.0001, OR=1.62, 95% CI=1.43â1.83, I2=81.2%; recessive model: p<0.0001, OR=2.01, 95% CI=1.75â2.30, I2=74.1%; allele model: P=0.001, OR=1.53, 95% CI=1.39â1.68, I2=84.8%). These significant correlations were further confirmed in Asian and Caucasian populations. A stratified analysis also showed a positive correlation between rs738409 and hepatocellular carcinoma (HCC), cirrhosis, and non-alcoholic fatty liver disease (NAFLD), but not with chronic hepatitis B infection or alcoholic liver disease.
Conclusions
Altogether, PNPLA3 rs738409 may help identify individuals at higher susceptibility to chronic liver disease, in particular for HCC, cirrhosis, and NAFLD.
Keywords
chronic liver disease,
meta-analysis,
rs738409,
single nucleotide polymorphism,
patatin-like phospholipase domain-containing-3,
PNPLA3
|
Copyright © 2025 Authors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
|
About this Article
Cite this article
|
Zheng Y, Wang L, Wang JH, Liang TJ, Zhao TJ. Impact of patatin-like phospholipase domain-containing-3 rs738409 polymorphism in chronic liver disease: a meta-analysis of 27,365 subjects. Gastroenterol & Hepatol Res. 2020;2(4):119-124. doi: 10.53388/ghr2020-12-025.
|
| Copied to clipboard
|
Copy
Export to RIS
Export to EndNote
|
|
Citation copied!
|
Article History
| Received |
Revised |
Accepted |
Published |
|
|
|
|
December 12, 2020
|
DOI
http://dx.doi.org/10.53388/ghr2020-12-025
-
Gastroenterology & Hepatology Research
-
-
eISSN 2703-173X