Chronic hepatitis B (CHB) affects more than 257 million individuals with high liver-related morbidity and mortality worldwide. This review summarizes research progress and reflection on new drugs for the treatment of CHB. Some available HBV therapeutic strategies and their corresponding stages of development from preclinical to various clinical phases are indicated in this article. Through this review, the author aims to give us a comprehensive understanding of the global research trends and the latest progress of new drugs for treating chronic hepatitis B, so as to gain useful enlightenment.