In this study, the effective components and related targets of Shugan Jieyu Capsule (SGJY) in the treatment of hepatitis B were determined to explore the mechanism of SGJY in the treatment of hepatitis B.

In this study, the effective components and targets of SGJY, and the related targets of hepatitis B were searched, and obtained the targets of SGJY in the treatment of hepatitis B according to the principle of Wenn diagram. To build a protein-protein interaction network, String database was used, Cytoscape (3.7.2) software was used for topology analysis, R (4.0.5) software was used for go analysis, KEGG pathway enrichment analysis, and study of putative signaling pathways to determine how they could work.

SZJY was used to predict a total of 11 Chinese herbal components and 85 associated targets for the treatment of hepatitis B. 34 important targets were examined, including AKT1, EGFR, and 10 important pathways were examined, including proteoglycans in cancer and the PI3K/Akt signaling pathway.

SGJY in the treatment of hepatitis B mainly inhibits the secretion of HBsAg and HBeAg by affecting PI3K-Akt and proteoglycans in cancer, and inhibits the progression of liver cancer.