Helicobacter pylori (H. pylori) infection is the most prevalent cause of gastric cancer. According to recent studies, the likelihood of developing gastric cancer can be significantly increased by subtle microbial differences and has hereditary traits. H. pylori and gastric mucosal begetter cells have a complex relationship because of their ability to recombine epithelial cells and activate stem cells. Gastric antecedent and stem cells can be directly influenced by cell-associated H. pylori, which can colonize gastric organs. The balance between H. pylori's activities as a symbiont or pathogen can be changed by external and natural factors, such as calories count and gastrointestinal microbiota, which provides information for determining its full carcinogenic potential.