Xia & He Publishing

Original Article

Hepatic and Biliary Neoplasia

A Multi-omics Investigation Identifies TACC3 as a Driver of Immunosuppression in Intrahepatic Cholangiocarcinoma via Activation of the STAT3-PD-L1 Axis

Hao Wang, Zhiquan Xu, Ziqi Zhang, Yan You, Ranning Xu, Hongli Chen, Hongshuai Cui, Xiaoyong Luo, Rui Liao

Published online: April 10, 2026

[ Html ] [ PDF Pages: 367-382 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):367-382. doi:10.14218/JCTH.2025.00616

Neu5Gc-associated Serum Immunoglobulin G Glycosylation as a Diagnostic Biomarker for Hepatocellular Carcinoma

Xu Cao, Xiwei Lu, Qingwei Li, Jiali Lu, Xiaoping Song, Yinglun Han, Chunwen Pu, Yue Pang

Published online: March 20, 2026

[ Html ] [ PDF Pages: 383-398 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):383-398. doi:10.14218/JCTH.2025.00654

Liver Transplantation and Surgery

Galectin-3 Promotes Graft Injury via NLRP3 Pyroptosis in Steatotic Liver Transplantation: A Therapeutic Target for Donor Optimization

Xianwu Yang, Shirui Huang, Ruisi Ma, Zhihui Zhu, Yingquan Zhuo, Jiafei Yang, Jun Du, Huajian Gu

Published online: March 24, 2026

[ Html ] [ PDF Pages: 399-415 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):399-415. doi:10.14218/JCTH.2025.00561

Metabolic Liver Diseases

Tongue Image Analysis and Clinical Data Fusion: A Novel Approach for Non-invasive Diagnosis of Metabolic Dysfunction-associated Fatty Liver Disease

Chen-Xia Lu, Chuan-Xi Tian, Yi-Bo Jiao, Hui Zhu, Hai-Yan Yu, Zi-Xin Shu, Ling-Han Zhang, Jia Zhang, Lan Wang, Qi Hao, Wen-Bin Zou, Ming-Zhong Xiao, Cheng-Hai Liu, Qiu-Yang He, Bee Luan Khoo, Xiao-Dong Li

Published online: April 8, 2026

[ Html ] [ PDF Pages: 416-429 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):416-429. doi:10.14218/JCTH.2025.00631

m1A Epitranscriptomic Control of NUPR1 by YTHDF1 Exacerbates Metabolic Dysregulation in Nonalcoholic Fatty Liver Disease

Nan Luo, Zhihai Xu, Dongmei Zhao, Xue Yang, Yu Tian, Rongkuan Li

Published online: April 2, 2026

[ Html ] [ PDF Pages: 430-439 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):430-439. doi:10.14218/JCTH.2025.00570

Liver Failure, Cirrhosis and Portal Hypertension

Single-cell Sequencing Reveals Neutrophil Extracellular Traps in Association with Endotheliopathy and Immunothrombosis in Hepatitis B Virus-related Acute-on-chronic Liver Failure

Xitang Li, Suping Hai, Xizhe Zheng, Peng Hu, Wenhui Wu, Qiang Gao, Junjian Hu, Binghui Yu, Feiyang Xu, Huiling Xiang, Qin Ning, Xiaojing Wang

Published online: April 10, 2026

[ Html ] [ PDF Pages: 440-451 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):440-451. doi:10.14218/JCTH.2025.00666

Infectious Hepatitis

Pegylated Interferon-based Treatment Improves Response Rates in Immune-tolerant Patients with Chronic Hepatitis B: A Prospective Trial

Min Liu, Lili Zuo, Yuting Zhang, Bing Bu, An Xiao, Ling Zhu, Xiuying Ma, Yilan Wang, Wei Yue, Jiawei Geng, Xueshan Xia

Published online: March 31, 2026

[ Html ] [ PDF Pages: 452-461 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):452-461. doi:10.14218/JCTH.2025.00712

Review Article

Unlocking the Future of Hepatocellular Carcinoma Early Diagnosis: The Promise of Extracellular Vesicle Biomarkers

Kunxiang Li, Zhihua Zuo, Xinyi Ou, Miyuan Yang, Yirui Qin, Bing Zhang, Yongcan Guo

Published online: April 8, 2026

[ Html ] [ PDF Pages: 462-477 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):462-477. doi:10.14218/JCTH.2025.00589

Congenital Portosystemic Shunts: A Review

George Y. Wu

Published online: February 4, 2026

[ Html ] [ PDF Pages: 478-486 ] [ Google Scholar ] [ Cite ]

J Clin Transl Hepatol. 2026;14(4):478-486. doi:10.14218/JCTH.2025.00090

Guideline

Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care (2025)

Wenjing Ni, Junping Shi, Jian-Gao Fan, Jie Li, Chronic Disease Management Branch of China Medical Biotechnology Association, Chinese Research Hospital Society (Integrative Chinese and Western Medicine), Chinese Society of General Practice, Chinese Medical Association, and Expert Group of Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care